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1
Cold or calculating? Reduced activity in the subgenual cingulate cortex reflects decreased emotional aversion to harming in counterintuitive utilitarian judgment
In: Cognition. - Amsterdam [u.a] : Elsevier 126 (2013) 3, 364-372
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2
Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism
In: ISSN: 0166-4328 ; EISSN: 1872-7549 ; Behavioural Brain Research ; https://hal-pasteur.archives-ouvertes.fr/pasteur-01580131 ; Behavioural Brain Research, Elsevier, 2013, 251 (1), pp.41 - 49. ⟨10.1016/j.bbr.2012.11.016⟩ (2013)
Abstract: International audience ; Autism is the short name of a complex and heterogeneous group of disorders (autism spectrum disorders, ASD) with several lead symptoms required for classification, including compromised social interaction, reduced verbal communication and stereotyped repetitive behaviors/restricted interests. The etiology of ASD is still unknown in most cases but monogenic heritable forms exist that have provided insights into ASD pathogenesis and have led to the notion of autism as a 'synapse disorder'. Among the most frequent monogenic causes of autism are loss-of-function mutations of the NLGN4X gene which encodes the synaptic cell adhesion protein neuroligin-4X (NLGN4X). We previously described autism-like behaviors in male Nlgn4 null mutant mice, including reduced social interaction and ultrasonic communication. Here, we extend the phenotypical characterization of Nlgn4 null mutant mice to both genders and add a series of additional autism-relevant behavioral readouts. We now report similar social interaction and ultrasonic communication deficits in females as in males. Furthermore, aggression, nest-building parameters, as well as self-grooming and circling as indicators of repetitive behaviors/stereotypies were explored in both genders. The construction of a gender-specific autism severity composite score for Nlgn4 mutant mice markedly diminishes population/sample heterogeneity typically obtained for single tests, resulting in p values of <0.00001 and a genotype predictability of 100% for male and of >83% for female mice. Taken together, these data underscore the similarity of phenotypical consequences of Nlgn4/NLGN4X loss-of-function in mouse and man, and emphasize the high relevance of Nlgn4 null mutant mice as an ASD model with both construct and face validity.
Keyword: [SCCO]Cognitive science; [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health; [SDV]Life Sciences [q-bio]; Animal; ASD; Gender differences; Grooming; Knockout; MESH: Animals; MESH: Autistic Disorder; MESH: Behavior; MESH: Carrier Proteins; MESH: Cell Adhesion Molecules; MESH: Disease Models; MESH: Female; MESH: Genetic Predisposition to Disease; MESH: Grooming; MESH: Male; MESH: Membrane Proteins; MESH: Mice; MESH: Phenotype; MESH: Severity of Illness Index; MESH: Sex Characteristics; MESH: Social Behavior; MESH: Stereotyped Behavior; MESH: Vocalization; Nest building; Neuronal; Repetitive behaviors; Social interaction; Stereotypies; Ultra-sound vocalization
URL: https://doi.org/10.1016/j.bbr.2012.11.016
https://hal-pasteur.archives-ouvertes.fr/pasteur-01580131
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3
How Artificial Intelligence Can link With Human Sciences
In: International Journal of Intelligent Computing Research ; https://halshs.archives-ouvertes.fr/halshs-01091071 ; International Journal of Intelligent Computing Research, 2013, 4 (1/2/3/4), pp.354-361 (2013)
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4
“Running the course” in the juvenile section : Towards a dialectic of times through the epistemology of science?
In: 14th European Prison Education Association Conference "Better Out" ; https://hal.archives-ouvertes.fr/hal-01164156 ; 14th European Prison Education Association Conference "Better Out", Jun 2013, Reykjavik, Iceland (2013)
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5
Tutoring Robots
In: IFIP Advances in Information and Communication Technology ; 9th International Summer Workshop on Multimodal Interfaces (eNTERFACE) ; https://hal.inria.fr/hal-01350740 ; 9th International Summer Workshop on Multimodal Interfaces (eNTERFACE), Jul 2013, Lisbon, Portugal. pp.80-113, &#x27E8;10.1007/978-3-642-55143-7_4&#x27E9; (2013)
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6
Modeling Context Effects in Science Learning: The CLASH Model
In: ISSN: 0302-9743 ; Lecture Notes in Computer Science ; https://hal.univ-antilles.fr/hal-01536068 ; Lecture Notes in Computer Science, Springer, 2013, CONTEXT 2013: Modeling and Using Context, 8175, pp.330 - 335. &#x27E8;10.1007/978-3-642-40972-1_25&#x27E9; (2013)
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7
Early-Detection System for Cross-Language (Translated) Plagiarism
In: Lecture Notes in Computer Science ; 1st International Conference on Information and Communication Technology (ICT-EurAsia) ; https://hal.inria.fr/hal-01480193 ; 1st International Conference on Information and Communication Technology (ICT-EurAsia), Mar 2013, Yogyakarta, Indonesia. pp.21-30, &#x27E8;10.1007/978-3-642-36818-9_3&#x27E9; (2013)
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8
Displaying Genealogy with Adoptions and Multiple Remarriages Using the WHIteBasE
In: Lecture Notes in Computer Science ; 12th International Conference on Information Systems and Industrial Management (CISIM) ; https://hal.inria.fr/hal-01496079 ; 12th International Conference on Information Systems and Industrial Management (CISIM), Sep 2013, Krakow, Poland. pp.325-336, &#x27E8;10.1007/978-3-642-40925-7_30&#x27E9; (2013)
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9
Olive baboons communicate intentionally by pointing
In: ISSN: 1435-9448 ; EISSN: 1435-9456 ; Animal Cognition ; https://hal.archives-ouvertes.fr/hal-01021754 ; Animal Cognition, Springer Verlag (Germany), 2013, 16 (2), pp.155-163. &#x27E8;10.1007/s10071-012-0558-y&#x27E9; (2013)
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10
CONTRIBUTIONS OF TALK, GESTURE AND SALIENT ELEMENTS OF THE SETTING TO ANALYSE STUDENT'S IDEAS IN SCIENCE THROUGH VIDEO
In: Esera ebook strand 3 science teaching processes ; ESERA ; https://hal-amu.archives-ouvertes.fr/hal-01201752 ; ESERA, Sep 2013, Nicosia, Cyprus (2013)
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11
Reading Comprehension in a Large Cohort of French First Graders from Low Socio-Economic Status Families: A 7-Month Longitudinal Study
In: ISSN: 1932-6203 ; EISSN: 1932-6203 ; PLoS ONE ; https://hal.archives-ouvertes.fr/hal-00906680 ; PLoS ONE, Public Library of Science, 2013, 8 (11), pp.e78608. &#x27E8;10.1371/journal.pone.0078608&#x27E9; (2013)
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12
Circuitos, perturbaciones y transformaciones de la modernidad/colonialidad : análisis discursivo en contextos chilenos y canadienses
Smith, Sara. - 2013
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13
La polysémie comme artefact des poètes. Variations sémantiques de samudrá- dans la Rksaṃhitā
In: Sens multiple(s) et polysémie : perspectives croisées, Orient & Occident ; https://hal.archives-ouvertes.fr/hal-01844519 ; Sens multiple(s) et polysémie : perspectives croisées, Orient & Occident, Jun 2013, Aix-en-Provence, France (2013)
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14
Argumentation et émotion dans les séquences textuelles journalistiques. À la recherche du profil discursif de stupeur et de jalousie
In: Nouvelles perspectives en sémantique lexicale et en organisation du discours ; https://hal.archives-ouvertes.fr/hal-01844535 ; Nouvelles perspectives en sémantique lexicale et en organisation du discours, Feb 2013, Osnabrück, Allemagne (2013)
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15
Lexical ambiguity in Machine Translation. Session 2 - Sense and Machine / Sens et machine. Session 2 - Sense and Machine
In: Actes du colloque Tralogy : Anticiper les technologies pour la traduction ; Tralogy II. Trouver le sens : où sont nos manques et nos besoins respectifs ? ; https://hal.archives-ouvertes.fr/hal-02498120 ; Tralogy II. Trouver le sens : où sont nos manques et nos besoins respectifs ?, Jan 2013, Paris, France (2013)
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16
Traduction pragmatique, linguistique de corpus, traducteur : un ménage à trois explosif ?. Session 3 - TA et Biotraduction
In: Actes du colloque Tralogy : Anticiper les technologies pour la traduction ; Tralogy II. Trouver le sens : où sont nos manques et nos besoins respectifs ? ; https://hal.archives-ouvertes.fr/hal-02497335 ; Tralogy II. Trouver le sens : où sont nos manques et nos besoins respectifs ?, Jan 2013, Paris, France. 15p (2013)
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17
Vert de rage, noire fureur. Propriétés des figements au sein du champ de la colère
In: XXXVe Colloque international de linguistique fonctionnelle ; https://hal.archives-ouvertes.fr/hal-01844512 ; XXXVe Colloque international de linguistique fonctionnelle, Sep 2013, Brno, République tchèque (2013)
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18
Enseigner la traduction humaine en s'inspirant de la traduction automatique. Session 7 -Pistes pour la recherche
In: Actes du colloque Tralogy : Anticiper les technologies pour la traduction ; Tralogy II. Trouver le sens : où sont nos manques et nos besoins respectifs ? ; https://hal.archives-ouvertes.fr/hal-02497949 ; Tralogy II. Trouver le sens : où sont nos manques et nos besoins respectifs ?, Jan 2013, Paris, France. 13p (2013)
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19
Les recherches dans le Trésor de la langue française informatisé. Session 4 - Terminologie et Lexicologie
In: Actes du colloque Tralogy : Anticiper les technologies pour la traduction ; Tralogy II. Trouver le sens : où sont nos manques et nos besoins respectifs ? ; https://hal.archives-ouvertes.fr/hal-02497370 ; Tralogy II. Trouver le sens : où sont nos manques et nos besoins respectifs ?, Jan 2013, Paris, France. 7p (2013)
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20
Procédés de traduction humaine mis en évidence dans les ruptures lexicogrammaticales avec la traduction d'un système de traduction automatique probabiliste
In: 7èmes Journées Internationales de la Linguistique de Corpus ; https://hal.archives-ouvertes.fr/hal-02306443 ; 7èmes Journées Internationales de la Linguistique de Corpus, Sep 2013, Lorient, France (2013)
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