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Auditory cortex activation to natural speech and simulated cochlear implant speech measured with functional near-infrared spectroscopy.
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Microstructure characterization of a decellularized vocal fold scaffold for laryngeal tissue engineering.
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In: The Laryngoscope, vol 124, iss 8 (2014)
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Abstract:
Objectives/hypothesisOne potential treatment for vocal fold injury or neoplasia is to replace the entire vocal fold with a tissue-engineered scaffold. This scaffold should ideally have similar mechanical properties and extracellular matrix composition as the native vocal fold. As one approach toward this goal, we decellularized human vocal folds and characterized their mechanical properties and extracellular matrix microstructure.Study designBasic science investigation.MethodsHuman vocal folds were dissected from the laryngeal framework and treated with sodium dodecyl sulfate (SDS) to remove all cells. Mechanical properties were measured by indentation before and after SDS treatment. The extracellular matrix components of collagen, laminin, elastin, and hyaluronic acid were also characterized before and after decellularization using histology and immunofluorescence.ResultsAfter 4 days of SDS treatment, we obtained a scaffold that retained the original geometry of the vocal fold but was devoid of cells. The elastic modulus of the vocal folds did not change significantly before and after decellularization. Upon qualitative inspection, the decellularized vocal folds retained the original collagen, elastin, and laminin content and orientation but lost the original hyaluronic acid.ConclusionsVocal folds can be decellularized using SDS without adversely affecting its mechanical stiffness and fibrous extracellular matrix. This preliminary study demonstrates the potential of a decellularized scaffold to serve as a tissue-engineered construct for vocal fold replacement.
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Keyword:
Clinical Sciences; decellularized; Humans; Larynx; Otorhinolaryngology; scaffolds; Tissue Engineering; Tissue Scaffolds; Vocal Cords; Vocal folds; Young's modulus
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URL: https://escholarship.org/uc/item/6zg627mv
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Bilateral versus unilateral cochlear implants in children: a study of spoken language outcomes
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Cepstral analysis of hypokinetic and ataxic voices : correlations with perceptual and other acoustic measures
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Vergleichende Studien einer neuen Sprachkodierungsstrategie für Cochlea-Implantate
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In: Naegeli, Andreas Mario. Vergleichende Studien einer neuen Sprachkodierungsstrategie für Cochlea-Implantate. 2014, University of Zurich, Faculty of Medicine. (2014)
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Semantic priming in anomic aphasia: a focused investigation using cross-modal methodology
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Can human mannequin-based simulation provide a feasible and clinically acceptable method for training tracheostomy management skills for speech pathologists?
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"For Māori, language is precious. And without it we are a bit lost": Māori experiences of aphasia
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Behavioural and neural changes after a “choice” therapy for naming deficits in aphasia: preliminary findings
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Living successfully with aphasia during the first year post-stroke: a longitudinal qualitative study
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A qualitative study of legal and social justice needs for people with aphasia
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Mealtime management in Australian Residential Aged Care: comparison of documented, reported and observed care
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Assessment of student competency in a simulated speech-language pathology clinical placement
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Ma¯ori experiences of aphasia therapy: "But I'm from Hauiti and we've got shags"
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Measuring outcomes in aphasia research: a review of current practice and an agenda for standardisation
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“Communication is taking a back seat”: speech pathologists’ perceptions of aphasia management in acute hospital settings
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Speech-language pathologists' contribution to the assessment of decision-making capacity in aphasia: a survey of common practices
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Feasibility and cost analysis of implementing high intensity aphasia clinics within a sub-acute setting
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Identifying language difference versus disorder in bilingual children
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