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1
Hand gestures and speech impairments in spoken and sung modalities in people with Alzheimer's disease
In: 4th Conference on Gesture and Speech in Interaction (GESPIN 4) ; https://hal.archives-ouvertes.fr/hal-01243140 ; 4th Conference on Gesture and Speech in Interaction (GESPIN 4), Sep 2015, Rennes, France. ⟨10.01195646⟩ ; http://www.gespin4.univ-nantes.fr/70179108/1/fiche___pagelibre/&RH=1412771102020&RF=1412770992428 (2015)
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2
Neural basis of motivational approach and withdrawal behaviors in neurodegenerative disease.
In: Brain and behavior, vol 5, iss 9 (2015)
Abstract: IntroductionThe Behavioral Inhibition System (BIS) and the Behavioral Activation System (BAS) have been theorized as neural systems that regulate approach/withdrawal behaviors. Behavioral activation/inhibition balance may change in neurodegenerative disease based on underlying alterations in systems supporting motivation and approach/withdrawal behaviors, which may in turn be reflected in neuropsychiatric symptoms.MethodA total of 187 participants (31 patients diagnosed with behavioral variant of FTD [bvFTD], 13 semantic variant of primary progressive aphasia [svPPA], 14 right temporal variant FTD [rtFTD], 54 Alzheimer's disease [AD], and 75 older healthy controls [NCs]) were included in this study. Changes in behavioral inhibition/activation were measured using the BIS/BAS scale. We analyzed the correlation between regional atrophy pattern and BIS/BAS score, using voxel-based morphometry (VBM).ResultsADs had significantly higher BIS scores than bvFTDs and NCs. bvFTDs activation-reward response (BAS-RR) was significantly lower than ADs and NCs, though their activation-drive (BAS-D) was significantly higher than in ADs. Both AD and rtFTD patients had abnormally low activation fun-seeking (BAS-FS) scores. BIS score correlated positively with right anterior cingulate and middle frontal gyrus volume, as well as volume in the right precentral gyrus and left insula/operculum.ConclusionsAD, bvFTD, and rtFTD patients show divergent patterns of change in approach/withdrawal reactivity. High BIS scores correlated with preservation of right-predominant structures involved in task control and self-protective avoidance of potentially negative reinforcers. Damage to these regions in bvFTD may create a punishment insensitivity that underlies patients' lack of self-consciousness in social contexts.
Keyword: 80 and over; Acquired Cognitive Impairment; Aged; Aging; Alzheimer's disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias; Alzheimer’s disease; and over; Basic Behavioral and Social Science; behavior inhibition; Behavioral and Social Science; Brain; Brain Disorders; Case-Control Studies; Clinical Research; Cognitive Sciences; Computer-Assisted; dementia; Emotions; Female; Frontotemporal Dementia; Humans; Image Processing; Magnetic Resonance Imaging; Male; Middle Aged; Motivation; neurodegeneration; Neurodegenerative; Neurosciences; Psychology; Punishment; Reward; Social Behavior; social concern; voxel-based morphometry
URL: https://escholarship.org/uc/item/68j7w60f
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3
Measuring gains in connected speech following treatment for word retrieval : a study with two participants with primary progressive aphasia
Nickels, Lyndsey; Jones, Kelly; Krein, Luisa. - : Routledge, 2015
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4
(Not) the 'right kind' of dementia story : re/presenting identities in reality theatre and performance
Gibson, Janet Louise. - : Sydney, Australia : Macquarie University, 2015
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5
Pain and temperature processing in dementia: a clinical and neuroanatomical analysis
In: Brain , 138 (11) pp. 3360-3372. (2015) (2015)
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6
Simultaneous PET-MRI Studies of the Concordance of Atrophy and Hypometabolism in Syndromic Variants of Alzheimer's Disease and Frontotemporal Dementia: An Extended Case Series.
In: J Alzheimers Dis , 46 (3) pp. 639-653. (2015) (2015)
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7
Age, schooling and Verbal Fluency tasks for the screening of Alzheimer´s disease patients ; Edad, escolarización y tareas de Fluencia Verbal para el screening de pacientes con Enfermedad de Alzheimer
In: Anales de Psicología / Annals of Psychology; Vol. 31 No. 3 (2015); 773-781 ; Anales de Psicología / Annals of Psychology; Vol. 31 Núm. 3 (2015); 773-781 ; 1695-2294 ; 0212-9728 (2015)
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