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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 13 of 13 1 Corpora and discourse studies : integrating discourse and corpora Baker, Paul (Hrsg.). - Basingstoke, Hampshire : Palgrave Macmillan, 2015 BLLDB UB Frankfurt Linguistik Show details 2 Corpora and discourse studies. Integrating discourse and corpora Baker, Paul (Hrsg.); McEnery, Tony (Hrsg.). - Basingstoke : Palgrave Macmillan, 2015 IDS Bibliografie zur Gesprächsforschung 3 Selective Blockade of CD28-Mediated T Cell Costimulation Protects Rhesus Monkeys against Acute Fatal Experimental Autoimmune Encephalomyelitis Haanstra, Krista,; Dijkman, Karin; Bashir, Noun; Bauer, Jan; Mary, Caroline; Poirier, Nicolas; Baker, Paul; Scobie, Linda; A. ’t Hart, Bert; Vanhove, Bernard In: ISSN: 0022-1767 ; EISSN: 1550-6606 ; Journal of Immunology ; https://www.hal.inserm.fr/inserm-02148517 ; Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2015, 194 (4), pp.1454-1466. ⟨10.4049/jimmunol.1402563⟩ (2015) Abstract: International audience ; Costimulatory and coinhibitory receptor–ligand pairs on T cells and APC control the immune response. We have investigated whether selective blockade of CD28–CD80/86 costimulatory interactions, which preserves the coinhibitory CTLA4–CD80/86 interactions and the function of regulatory T (Treg) cells, abrogates the induction of experimental autoimmune encephalomyelitis (EAE) in rhesus monkeys. EAE was induced by intracutaneous immunization with recombinant human myelin oligodendrocyte glycoprotein (rhMOG) in CFA on day 0. FR104 is a monovalent, PEGylated-humanized Fab9 Ab fragment against human CD28, cross-reactive with rhesus monkey CD28. FR104 or placebo was administered on days 0, 7, 14, and 21. FR104 levels remained high until the end of the study (day 42). Placebo-treated animals all developed clinical EAE between days 12 and 27. FR104-treated animals did not develop clinical EAE and were sacrificed at the end of the study resulting in a significantly prolonged survival. FR104 treatment diminished T and B cell responses against rhMOG, significantly reduced CNS inflammation and prevented demyelination. The inflammatory profile in the cerebrospinal fluid and brain material was also strongly reduced. Recrudescence of latent virus was investigated in blood, spleen, and brain. No differences between groups were observed for the b-herpesvirus CMV and the polyomaviruses SV40 and SA12. Cross-sectional measurement of lymphocryptovirus, the rhesus monkey EBV, demonstrated elevated levels in the blood of FR104-treated animals. Blocking rhesus monkey CD28 with FR104 mitigated autoreactive T and B cell activation and prevented CNS pathology in the rhMOG/CFA EAE model in rhesus monkeys. Keyword: [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology URL: https://www.hal.inserm.fr/inserm-02148517/file/2015selective1454.full.pdf https://www.hal.inserm.fr/inserm-02148517/document https://doi.org/10.4049/jimmunol.1402563 https://www.hal.inserm.fr/inserm-02148517 BASE Hide details 4 Two hundred years of the American man Baker, Paul In: Language and masculinities. - New York : Routledge (2015), 34-52 BLLDB Show details 5 Picking the right cherries? A comparison of corpus-based and qualitative analyses of news articles about masculinity ... Baker, Paul; Levon, Erez. - : Sage, 2015 BASE Show details 6 Two hundred years of the American man Baker, Paul. - : Routledge, 2015 BASE Show details 7 Who benefits when discourse gets democratised?:analysing a Twitter corpus around the British Benefits Street debate Baker, Paul; McEnery, Tony. - : Palgrave Macmillan, 2015 BASE Show details 8 ProtAnt:A tool for analysing the prototypicality of texts Anthony, Laurence; Baker, Paul. - 2015 BASE Show details 9 The hate that dare not speak its name? Love, Robbie; Baker, Paul. - 2015 BASE Show details 10 Thinking about the news : thought presentation in early modern English news writing Walker, Brian; McIntyre, Dan. - : Palgrave Macmillan, 2015 BASE Show details 11 e-Language: communication in the digital age Knight, Dawn. - : Palgrave Macmillan, London, 2015 BASE Show details 12 Beyond monomodal spoken corpora Adolphs, Svenja; Knight, Dawn. - : Palgrave Macmillan, 2015 BASE Show details 13 Filtering the flood: semantic tagging as a method of identifying salient discourse topics in a large corpus of Hurricane Katrina reportage Potts, Amanda. - : Palgrave, 2015 BASE Show details

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