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Age-Related Differences in Cortical Thickness Vary by Socioeconomic Status
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| 2 |
Age-Related Differences in Cortical Thickness Vary by Socioeconomic Status
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| 3 |
Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 12, iss 3 (2016)
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| 4 |
Spatial resolution dependence on spectral frequency in human speech cortex electrocorticography.
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In: Journal of neural engineering, vol 13, iss 5 (2016)
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| 5 |
Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 12, iss 3 (2016)
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| 6 |
Spatial resolution dependence on spectral frequency in human speech cortex electrocorticography.
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In: Journal of neural engineering, vol 13, iss 5 (2016)
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| 7 |
Therapy and clinical trials in frontotemporal dementia: past, present, and future.
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In: Journal of neurochemistry, vol 138 Suppl 1, iss S1 (2016)
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| 8 |
Increased prevalence of autoimmune disease within C9 and FTD/MND cohorts: Completing the picture.
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In: Neurology(R) neuroimmunology & neuroinflammation, vol 3, iss 6 (2016)
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| 9 |
Usage-based approaches to aphasia
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In: Aphasiology, vol 30, iss 11 (2016)
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| 10 |
Increased subcortical neural activity among HIV+ individuals during a lexical retrieval task.
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In: Neurobiology of disease, vol 92, iss Pt B (2016)
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Abstract:
BackgroundDeficits in lexical retrieval, present in approximately 40% of HIV+ patients, are thought to reflect disruptions to frontal-striatal functions and may worsen with immunosuppression. Coupling frontal-striatal tasks such as lexical retrieval with functional neuroimaging may help delineate the pathophysiologic mechanisms underlying HIV-associated neurological dysfunction.ObjectiveWe examined whether HIV infection confers brain functional changes during lexical access and retrieval. It was expected that HIV+ individuals would demonstrate greater brain activity in frontal-subcortical regions despite minimal differences between groups on neuropsychological testing. Within the HIV+ sample, we examined associations between indices of immunosuppression (recent and nadir CD4+ count) and task-related signal change in frontostriatal structures. Method16 HIV+ participants and 12 HIV- controls underwent fMRI while engaged in phonemic/letter and semantic fluency tasks. Participants also completed standardized measures of verbal fluencyResultsHIV status groups performed similarly on phonemic and semantic fluency tasks prior to being scanned. fMRI results demonstrated activation differences during the phonemic fluency task as a function of HIV status, with HIV+ individuals demonstrating significantly greater activation in BG structures than HIV- individuals. There were no significant differences in frontal brain activation between HIV status groups during the phonemic fluency task, nor were there significant brain activation differences during the semantic fluency task. Within the HIV+ group, current CD4+ count, though not nadir, was positively correlated with increased activity in the inferior frontal gyrus and basal ganglia.ConclusionDuring phonemic fluency performance, HIV+ patients recruit subcortical structures to a greater degree than HIV- controls despite similar task performances suggesting that fMRI may be sensitive to neurocompromise before overt cognitive declines can be detected. Among HIV+ individuals, reduced activity in the frontal-subcortical structures was associated with lower CD4+ count.
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Keyword:
Brain; Brain Mapping; Cerebrovascular Circulation; Clinical Sciences; Female; HIV; HIV Infections; Humans; Immunosuppression; Lexical retrieval; Magnetic Resonance Imaging; Male; Middle Aged; Neuroimaging; Neurology & Neurosurgery; Neuropsychological Tests; Neurosciences; Oxygen; Phonetics; Semantics; Speech; Verbal fluency
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URL: https://escholarship.org/uc/item/7bw1652p
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| 11 |
Rapid tuning shifts in human auditory cortex enhance speech intelligibility.
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In: Nature communications, vol 7, iss 1 (2016)
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The auditory representation of speech sounds in human motor cortex.
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In: eLife, vol 5, iss MARCH2016 (2016)
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| 13 |
Rapid tuning shifts in human auditory cortex enhance speech intelligibility.
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In: Nature communications, vol 7, iss 1 (2016)
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| 14 |
Neuroanatomical anomalies of dyslexia: Disambiguating the effects of disorder, performance, and maturation.
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| 15 |
Effects of HIV and childhood trauma on brain morphometry and neurocognitive function.
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In: Journal of neurovirology, vol 22, iss 2 (2016)
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| 16 |
A human neurodevelopmental model for Williams syndrome.
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In: Nature, vol 536, iss 7616 (2016)
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Multivariate pattern classification of pediatric Tourette syndrome using functional connectivity MRI.
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In: Developmental science, vol 19, iss 4 (2016)
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A human neurodevelopmental model for Williams syndrome.
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In: Nature, vol 536, iss 7616 (2016)
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| 19 |
Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children.
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In: Brain imaging and behavior, vol 10, iss 1 (2016)
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| 20 |
Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children.
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In: Brain imaging and behavior, vol 10, iss 1 (2016)
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