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Neuroeconomic dissociation of semantic dementia and behavioural variant frontotemporal dementia
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In: Chiong, W; Wood, KA; Beagle, AJ; Hsu, M; Kayser, AS; Miller, BL; et al.(2016). Neuroeconomic dissociation of semantic dementia and behavioural variant frontotemporal dementia. Brain, 139(2), 578 - 587. doi:10.1093/brain/awv344. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/9xz796qz (2016)
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Abstract:
© 2015 The Author (2015). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. Many neuropsychiatric disorders are marked by abnormal behaviour and decision-making, but prevailing diagnostic criteria for such behaviours are typically qualitative and often ambiguous. Behavioural variant frontotemporal dementia and semantic variant primary progressive aphasia (also called semantic dementia) are two clinical variants of frontotemporal dementia with overlapping but distinct anatomical substrates known to cause profound changes in decision-making. We investigated whether abnormal decision-making in these syndromes could be more precisely characterized in terms of dissociable abnormalities in patients' subjective evaluations of valence (positive versus negative outcome) and of time (present versus future outcome). We presented 28 patients with behavioural variant frontotemporal dementia, 14 patients with semantic variant primary progressive aphasia, 25 patients with Alzheimer's disease (as disease controls), and 61 healthy older control subjects with experimental tasks assaying loss aversion and delay discounting. In general linear models controlling for age, gender, education and Mini-Mental State Examination score, patients with behavioural variant frontotemporal dementia were less averse to losses than control subjects (P < 0.001), while patients with semantic variant primary progressive aphasia discounted delayed rewards more steeply than controls (P = 0.019). There was no relationship between loss aversion and delay discounting across the sample, nor in any of the subgroups. These findings suggest that abnormal behaviours in neurodegenerative disease may result from the disruption of either of two dissociable neural processes for evaluating the outcomes of action. More broadly, these findings suggest a role for computational methods to supplement traditional qualitative characterizations in the differential diagnosis of neuropsychiatric disorders.
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Keyword:
behavioural neurology; computational psychiatry; frontotemporal dementia; impulsivity and inhibition disorders; semantic dementia
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URL: http://www.escholarship.org/uc/item/9xz796qz
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Analyzing bilingual advantage in metalinguistic awareness: the roles of executive functioning and vocabulary knowledge on metalinguistic tasks
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Sun, Lichao. - : eScholarship, University of California, 2016
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In: Sun, Lichao. (2016). Analyzing bilingual advantage in metalinguistic awareness: the roles of executive functioning and vocabulary knowledge on metalinguistic tasks. UCLA: Education 0249. Retrieved from: http://www.escholarship.org/uc/item/5wn18640 (2016)
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Neuroeconomic dissociation of semantic dementia and behavioural variant frontotemporal dementia.
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In: Brain : a journal of neurology, vol 139, iss Pt 2 (2016)
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Behavioral approach and fear moderates the relationship between insensitive/intrusive parenting and early language development
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The effect of childhood bilectalism and multilingualism on executive control. ...
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Speech Comprehension Difficulties in Chronic Tinnitus and Its Relation to Hyperacusis ...
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Backward semantic inhibition in toddlers
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In: Symplectic Elements at Oxford ; Added by author ; ORA review team (2016)
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Inhibitory deficits in aphasia ; role of neurovisceral integration
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Forgetting the Literal: The Role of Inhibition in Metaphor Comprehension
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Executive control in older Welsh monolinguals and bilinguals
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The effect of childhood bilectalism and multilingualism on executive control.
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L’intégration des identités : contraste de deux hypothèses contradictoires
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The Number of Genomic Copies at the 16p11.2 Locus Modulates Language, Verbal Memory, and Inhibition.
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In: Biological psychiatry, vol. 80, no. 2, pp. 129-139 (2016)
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On the relationship between response selection and response inhibition: an individual differences approach
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