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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Page: 1 2 Hits 1 – 20 of 26 1 Hemodynamics of speech production: an fNIRS investigation of children who stutter Yucel, Meryem; Tian, F.; Bostian, A.. - : Nature Publishing Group, 2017 BASE Show details 2 Exploring Cognitive Relations Between Prediction in Language and Music. Patel, Aniruddh D; Morgan, Emily In: Cognitive science, vol 41 Suppl 2, iss S2 (2017) BASE Show details 3 Neural correlates of language variability in preschool-aged boys with autism spectrum disorder. Naigles, Letitia R; Johnson, Ryan; Mastergeorge, Ann... In: Autism research : official journal of the International Society for Autism Research, vol 10, iss 6 (2017) BASE Show details 4 Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease. Elahi, Fanny M; Marx, Gabe; Cobigo, Yann; Staffaroni, Adam M; Kornak, John; Tosun, Duygu; Boxer, Adam L; Kramer, Joel H; Miller, Bruce L; Rosen, Howard J. - : eScholarship, University of California, 2017 Abstract: BackgroundDegradation of white matter microstructure has been demonstrated in frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD). In preparation for clinical trials, ongoing studies are investigating the utility of longitudinal brain imaging for quantification of disease progression. To date only one study has examined sample size calculations based on longitudinal changes in white matter integrity in FTLD.ObjectiveTo quantify longitudinal changes in white matter microstructural integrity in the three canonical subtypes of frontotemporal dementia (FTD) and AD using diffusion tensor imaging (DTI).Methods60 patients with clinical diagnoses of FTD, including 27 with behavioral variant frontotemporal dementia (bvFTD), 14 with non-fluent variant primary progressive aphasia (nfvPPA), and 19 with semantic variant PPA (svPPA), as well as 19 patients with AD and 69 healthy controls were studied. We used a voxel-wise approach to calculate annual rate of change in fractional anisotropy (FA) and mean diffusivity (MD) in each group using two time points approximately one year apart. Mean rates of change in FA and MD in 48 atlas-based regions-of-interest, as well as global measures of cognitive function were used to calculate sample sizes for clinical trials (80% power, alpha of 5%).ResultsAll FTD groups showed statistically significant baseline and longitudinal white matter degeneration, with predominant involvement of frontal tracts in the bvFTD group, frontal and temporal tracts in the PPA groups and posterior tracts in the AD group. Longitudinal change in MD yielded a larger number of regions with sample sizes below 100 participants per therapeutic arm in comparison with FA. SvPPA had the smallest sample size based on change in MD in the fornix (n=41 participants per study arm to detect a 40% effect of drug), and nfvPPA and AD had their smallest sample sizes based on rate of change in MD within the left superior longitudinal fasciculus (n=49 for nfvPPA, and n=23 for AD). BvFTD generally showed the largest sample size estimates (minimum n=140 based on MD in the corpus callosum). The corpus callosum appeared to be the best region for a potential study that would include all FTD subtypes. Change in global measure of functional status (CDR box score) yielded the smallest sample size for bvFTD (n=71), but clinical measures were inferior to white matter change for the other groups.ConclusionsAll three of the canonical subtypes of FTD are associated with significant change in white matter integrity over one year. These changes are consistent enough that drug effects in future clinical trials could be detected with relatively small numbers of participants. While there are some differences in regions of change across groups, the genu of the corpus callosum is a region that could be used to track progression in studies that include all subtypes. Keyword: 2.1 Biological and endogenous factors; Acquired Cognitive Impairment; AD; Aged; Aging; Alzheimer Disease; Alzheimer's Disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer's Disease Related Dementias (ADRD); Behavioral and Social Science; Behavioral variant FTD; Biomedical Imaging; Brain; Brain Disorders; Clinical Research; Clinical trial; Clinical Trials and Supportive Activities; Cross-Sectional Studies; Dementia; Diffusion Tensor Imaging; DTI; Female; Frontotemporal Dementia; Frontotemporal Dementia (FTD); FTD; Humans; Longitudinal; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Neurodegenerative; Neurological; Neurosciences; Primary progressive aphasia; Rare Diseases; Retrospective Studies; Sample Size; White Matter; White matter integrity URL: https://escholarship.org/uc/item/36t974qr BASE Hide details 5 Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease. Elahi, Fanny M; Marx, Gabe; Cobigo, Yann. - : eScholarship, University of California, 2017 BASE Show details 6 A neural network underlying intentional emotional facial expression in neurodegenerative disease. Gola, Kelly A; Shany-Ur, Tal; Pressman, Peter. - : eScholarship, University of California, 2017 BASE Show details 7 A neural network underlying intentional emotional facial expression in neurodegenerative disease. Gola, Kelly A; Shany-Ur, Tal; Pressman, Peter. - : eScholarship, University of California, 2017 BASE Show details 8 Observing conversational laughter in frontotemporal dementia. Pressman, Peter S; Simpson, Michaela; Gola, Kelly... In: Journal of neurology, neurosurgery, and psychiatry, vol 88, iss 5 (2017) BASE Show details 9 Emotion detection deficits and changes in personality traits linked to loss of white matter integrity in primary progressive aphasia. Multani, Namita; Galantucci, Sebastiano; Wilson, Stephen M. - : eScholarship, University of California, 2017 BASE Show details 10 Observing conversational laughter in frontotemporal dementia. Pressman, Peter S; Simpson, Michaela; Gola, Kelly... In: Journal of neurology, neurosurgery, and psychiatry, vol 88, iss 5 (2017) BASE Show details 11 Action mechanisms for social cognition: behavioral and neural correlates of developing Theory of Mind. Bowman, Lindsay C; Thorpe, Samuel G; Cannon, Erin N... In: Developmental science, vol 20, iss 5 (2017) BASE Show details 12 Improving language mapping in clinical fMRI through assessment of grammar. Połczyńska, Monika; Japardi, Kevin; Curtiss, Susan. - : eScholarship, University of California, 2017 BASE Show details 13 Improving language mapping in clinical fMRI through assessment of grammar. Połczyńska, Monika; Japardi, Kevin; Curtiss, Susan. - : eScholarship, University of California, 2017 BASE Show details 14 Early changes in brain structure correlate with language outcomes in children with neonatal encephalopathy. Shapiro, Kevin A; Kim, Hosung; Mandelli, Maria Luisa. - : eScholarship, University of California, 2017 BASE Show details 15 Investigation of autistic traits through strategic decision-making in games with adaptive agents. Craig, Alexis B; Grossman, Emily; Krichmar, Jeffrey L In: Scientific reports, vol 7, iss 1 (2017) BASE Show details 16 A common neural hub resolves syntactic and non-syntactic conflict through cooperation with task-specific networks. Hsu, Nina S; Jaeggi, Susanne M; Novick, Jared M. - : eScholarship, University of California, 2017 BASE Show details 17 On the role of the corpus callosum in interhemispheric functional connectivity in humans. Roland, Jarod L; Snyder, Abraham Z; Hacker, Carl D... In: Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 50 (2017) BASE Show details 18 You talkin' to me? Communicative talker gaze activates left-lateralized superior temporal cortex during perception of degraded speech. ... McGettigan, Carolyn; Jasmin, Kyle; Eisner, Frank. - : Apollo - University of Cambridge Repository, 2017 BASE Show details 19 Predicting primary progressive aphasias with support vector machine approaches in structural MRI data. Bisenius, Sandrine; Mueller, Karsten; Diehl-Schmid, Janine. - 2017 BASE Show details 20 You talkin' to me? Communicative talker gaze activates left-lateralized superior temporal cortex during perception of degraded speech. McGettigan, Carolyn; Jasmin, Kyle; Eisner, Frank. - : Elsevier BV, 2017. : Neuropsychologia, 2017 BASE Show details Page: 1 2

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