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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 5 of 5 1 Data-driven regions of interest for longitudinal change in three variants of frontotemporal lobar degeneration. Binney, Richard J; Pankov, Aleksandr; Marx, Gabriel... In: Brain and behavior, vol 7, iss 4 (2017) BASE Show details 2 Observing conversational laughter in frontotemporal dementia. Pressman, Peter S; Simpson, Michaela; Gola, Kelly... In: Journal of neurology, neurosurgery, and psychiatry, vol 88, iss 5 (2017) BASE Show details 3 Observing conversational laughter in frontotemporal dementia. Pressman, Peter S; Simpson, Michaela; Gola, Kelly; Shdo, Suzanne M; Spinelli, Edoardo G; Miller, Bruce L; Gorno-Tempini, Maria Luisa; Rankin, Katherine; Levenson, Robert W In: Journal of neurology, neurosurgery, and psychiatry, vol 88, iss 5 (2017) Abstract: BackgroundWe performed an observational study of laughter during seminaturalistic conversations between patients with dementia and familial caregivers. Patients were diagnosed with (1) behavioural variant frontotemporal dementia (bvFTD), (2) right temporal variant frontotemporal dementia (rtFTD), (3) semantic variant of primary progressive aphasia (svPPA), (4) non-fluent variant primary progressive aphasia (nfvPPA) or (5) early onset Alzheimer's disease (eoAD). We hypothesised that those with bvFTD would laugh less in response to their own speech than other dementia groups or controls, while those with rtFTD would laugh less regardless of who was speaking.MethodsPatients with bvFTD (n=39), svPPA (n=19), rtFTD (n=14), nfvPPA (n=16), eoAD (n=17) and healthy controls (n=156) were recorded (video and audio) while discussing a problem in their relationship with a healthy control companion. Using the audio track only, laughs were identified by trained coders and then further classed by an automated algorithm as occurring during or shortly after the participant's own vocalisation ('self' context) or during or shortly after the partner's vocalisation ('partner' context).ResultsIndividuals with bvFTD, eoAD or rtFTD laughed less across both contexts of self and partner than the other groups. Those with bvFTD laughed less relative to their own speech comparedwith healthy controls. Those with nfvPPA laughed more in the partner context compared with healthy controls.ConclusionsLaughter in response to one's own vocalisations or those of a conversational partner may be a clinically useful measure in dementia diagnosis. Keyword: 2.1 Biological and endogenous factors; Acquired Cognitive Impairment; Aged; Aging; Alzheimer Disease; Alzheimer's Disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Aphasia; Brain; Brain Disorders; Clinical Research; Dementia; Female; Frontotemporal Dementia; Frontotemporal Dementia (FTD); Humans; Laughter; Magnetic Resonance Imaging; Male; Medical and Health Sciences; Middle Aged; Neurodegenerative; Neurological; Neurology & Neurosurgery; Neuropsychological Tests; Neurosciences; Primary Progressive; Primary Progressive Nonfluent Aphasia; Psychology and Cognitive Sciences; Rare Diseases; Speech URL: https://escholarship.org/uc/item/6r4531sc BASE Hide details 4 Data-driven regions of interest for longitudinal change in three variants of frontotemporal lobar degeneration. Binney, Richard J; Pankov, Aleksandr; Marx, Gabriel... In: Brain and behavior, vol 7, iss 4 (2017) BASE Show details 5 Early changes in brain structure correlate with language outcomes in children with neonatal encephalopathy. Shapiro, Kevin A; Kim, Hosung; Mandelli, Maria Luisa. - : eScholarship, University of California, 2017 BASE Show details

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