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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 5 of 5 1 Data-driven regions of interest for longitudinal change in three variants of frontotemporal lobar degeneration. Binney, Richard J; Pankov, Aleksandr; Marx, Gabriel... In: Brain and behavior, vol 7, iss 4 (2017) BASE Show details 2 Observing conversational laughter in frontotemporal dementia. Pressman, Peter S; Simpson, Michaela; Gola, Kelly... In: Journal of neurology, neurosurgery, and psychiatry, vol 88, iss 5 (2017) BASE Show details 3 Observing conversational laughter in frontotemporal dementia. Pressman, Peter S; Simpson, Michaela; Gola, Kelly... In: Journal of neurology, neurosurgery, and psychiatry, vol 88, iss 5 (2017) BASE Show details 4 Data-driven regions of interest for longitudinal change in three variants of frontotemporal lobar degeneration. Binney, Richard J; Pankov, Aleksandr; Marx, Gabriel... In: Brain and behavior, vol 7, iss 4 (2017) BASE Show details 5 Early changes in brain structure correlate with language outcomes in children with neonatal encephalopathy. Shapiro, Kevin A; Kim, Hosung; Mandelli, Maria Luisa; Rogers, Elizabeth E; Gano, Dawn; Ferriero, Donna M; Barkovich, A James; Gorno-Tempini, Maria Luisa; Glass, Hannah C; Xu, Duan. - : eScholarship, University of California, 2017 Abstract: Global patterns of brain injury correlate with motor, cognitive, and language outcomes in survivors of neonatal encephalopathy (NE). However, it is still unclear whether local changes in brain structure predict specific deficits. We therefore examined whether differences in brain structure at 6 months of age are associated with neurodevelopmental outcomes in this population. We enrolled 32 children with NE, performed structural brain MR imaging at 6 months, and assessed neurodevelopmental outcomes at 30 months. All subjects underwent T1-weighted imaging at 3 T using a 3D IR-SPGR sequence. Images were normalized in intensity and nonlinearly registered to a template constructed specifically for this population, creating a deformation field map. We then used deformation based morphometry (DBM) to correlate variation in the local volume of gray and white matter with composite scores on the Bayley Scales of Infant and Toddler Development (Bayley-III) at 30 months. Our general linear model included gestational age, sex, birth weight, and treatment with hypothermia as covariates. Regional brain volume was significantly associated with language scores, particularly in perisylvian cortical regions including the left supramarginal gyrus, posterior superior and middle temporal gyri, and right insula, as well as inferior frontoparietal subcortical white matter. We did not find significant correlations between regional brain volume and motor or cognitive scale scores. We conclude that, in children with a history of NE, local changes in the volume of perisylvian gray and white matter at 6 months are correlated with language outcome at 30 months. Quantitative measures of brain volume on early MRI may help identify infants at risk for poor language outcomes. Keyword: Bayley Scales of Infant and Toddler Development; Bayley-III; Brain; Brain Mapping; Child; Cognition Disorders; DBM; deformation based morphometry; Developmental Disabilities; Female; Humans; Hypoxic-ischemic encephalopathy; Infant; Language; Language Development Disorders; Magnetic Resonance Imaging; Male; NE; neonatal encephalopathy; neuromotor score; Neuropsychological Tests; Neurosciences; NMS; Third Edition URL: https://escholarship.org/uc/item/9d5640dq BASE Hide details

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