1 |
Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease.
|
|
|
|
BASE
|
|
Show details
|
|
2 |
Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease.
|
|
|
|
BASE
|
|
Show details
|
|
3 |
Data-driven regions of interest for longitudinal change in three variants of frontotemporal lobar degeneration
|
|
|
|
In: Binney, RJ; Pankov, A; Marx, G; He, X; McKenna, F; Staffaroni, AM; et al.(2017). Data-driven regions of interest for longitudinal change in three variants of frontotemporal lobar degeneration. BRAIN AND BEHAVIOR, 7(4), e00675. doi:10.1002/brb3.675. UCSF: Retrieved from: http://www.escholarship.org/uc/item/1xd9f3hr (2017)
|
|
BASE
|
|
Show details
|
|
4 |
A neural network underlying intentional emotional facial expression in neurodegenerative disease.
|
|
|
|
BASE
|
|
Show details
|
|
5 |
Grammar and the use of data
|
|
|
|
In: Sprouse, Jon; & Schütze, Carson T. (2017). Grammar and the use of data. In The Oxford Handbook of English Grammar Location: Oxford University Press. UCLA: Retrieved from: http://www.escholarship.org/uc/item/0n100842 (2017)
|
|
BASE
|
|
Show details
|
|
6 |
A neural network underlying intentional emotional facial expression in neurodegenerative disease.
|
|
|
|
BASE
|
|
Show details
|
|
7 |
Data-driven regions of interest for longitudinal change in three variants of frontotemporal lobar degeneration.
|
|
|
|
In: Brain and behavior, vol 7, iss 4 (2017)
|
|
BASE
|
|
Show details
|
|
8 |
Observing conversational laughter in frontotemporal dementia.
|
|
|
|
In: Journal of neurology, neurosurgery, and psychiatry, vol 88, iss 5 (2017)
|
|
BASE
|
|
Show details
|
|
9 |
Observing conversational laughter in frontotemporal dementia.
|
|
|
|
In: Journal of neurology, neurosurgery, and psychiatry, vol 88, iss 5 (2017)
|
|
BASE
|
|
Show details
|
|
10 |
Data-driven regions of interest for longitudinal change in three variants of frontotemporal lobar degeneration.
|
|
|
|
In: Brain and behavior, vol 7, iss 4 (2017)
|
|
BASE
|
|
Show details
|
|
11 |
Improving language mapping in clinical fMRI through assessment of grammar.
|
|
|
|
BASE
|
|
Show details
|
|
12 |
Improving language mapping in clinical fMRI through assessment of grammar.
|
|
|
|
BASE
|
|
Show details
|
|
13 |
Early changes in brain structure correlate with language outcomes in children with neonatal encephalopathy.
|
|
|
|
BASE
|
|
Show details
|
|
14 |
A common neural hub resolves syntactic and non-syntactic conflict through cooperation with task-specific networks.
|
|
|
|
BASE
|
|
Show details
|
|
15 |
Hippocampal activation is associated with longitudinal amyloid accumulation and cognitive decline.
|
|
|
|
Abstract:
The amyloid hypothesis suggests that beta-amyloid (Aβ) deposition leads to alterations in neural function and ultimately to cognitive decline in Alzheimer's disease. However, factors that underlie Aβ deposition are incompletely understood. One proposed model suggests that synaptic activity leads to increased Aβ deposition. More specifically, hyperactivity in the hippocampus may be detrimental and could be one factor that drives Aβ deposition. To test this model, we examined the relationship between hippocampal activity during a memory task using fMRI and subsequent longitudinal change in Aβ using PIB-PET imaging in cognitively normal older adults. We found that greater hippocampal activation at baseline was associated with increased Aβ accumulation. Furthermore, increasing Aβ accumulation mediated the influence of hippocampal activation on declining memory performance, demonstrating a crucial role of Aβ in linking hippocampal activation and memory. These findings support a model linking increased hippocampal activation to subsequent Aβ deposition and cognitive decline.
|
|
Keyword:
80 and over; Aged; aging; amyloid; Amyloid beta-Peptides; and over; Biochemistry and Cell Biology; Cognitive Dysfunction; Female; Hippocampus; human; Humans; longitudinal; Longitudinal Studies; Magnetic Resonance Imaging; Male; memory; neuroscience; PIB; Positron-Emission Tomography
|
|
URL: https://escholarship.org/uc/item/8mx340ng
|
|
BASE
|
|
Hide details
|
|
16 |
You talkin' to me? Communicative talker gaze activates left-lateralized superior temporal cortex during perception of degraded speech. ...
|
|
|
|
BASE
|
|
Show details
|
|
17 |
Predicting primary progressive aphasias with support vector machine approaches in structural MRI data.
|
|
|
|
BASE
|
|
Show details
|
|
18 |
Distinct processing of ambiguous speech in people with non-clinical auditory verbal hallucinations
|
|
|
|
BASE
|
|
Show details
|
|
19 |
You talkin' to me? Communicative talker gaze activates left-lateralized superior temporal cortex during perception of degraded speech.
|
|
|
|
BASE
|
|
Show details
|
|
20 |
MRI-Based Neuroanatomical Predictors of Dysphagia, Dysarthria, and Aphasia in Patients with First Acute Ischemic Stroke
|
|
|
|
BASE
|
|
Show details
|
|
|
|