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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Page: 1 2 3 4 5 6 Hits 1 – 20 of 110 1 Control of the glottal configuration in ex vivo human models: quantitative anatomy for clinical and experimental practices. Lagier, Aude; Guenoun, Daphné; Legou, Thierry... In: Surgical and radiologic anatomy : SRA ; https://hal.archives-ouvertes.fr/hal-03550302 ; Surgical and radiologic anatomy : SRA, 2017, 39 (3), pp.257--262. ⟨10.1007/s00276-016-1738-2⟩ (2017) BASE Show details 2 Mycobacterium ulcerans infection (Buruli ulcer) in French Guiana, South America, 1969–2013: an epidemiological study Douine, Maylis; Gozlan, Rodolphe; Nacher, Mathieu... In: ISSN: 2542-5196 ; EISSN: 2542-5196 ; Lancet Planetary Health ; https://www.hal.inserm.fr/inserm-01545603 ; Lancet Planetary Health , Elsevier, 2017, 1 (2), pp.65-73. ⟨10.1016/S2542-5196(17)30009-8⟩ (2017) BASE Show details 3 Factors related to the relative survival of patients with diffuse large B-cell lymphoma in a population-based study in France: does socio-economic status have a role? Le Guyader-Peyrou, Sandra; Orazio, Sébastien; Dejardin, Olivier... In: ISSN: 0390-6078 ; EISSN: 1592-8721 ; Haematologica ; https://hal.archives-ouvertes.fr/hal-01559872 ; Haematologica, Ferrata Storti Foundation, 2017, 102 (3), pp.584-592. ⟨10.3324/haematol.2016.152918⟩ ; http://www.haematologica.org/content/102/3/584.long (2017) BASE Show details 4 Hemodynamics of speech production: an fNIRS investigation of children who stutter Yucel, Meryem; Tian, F.; Bostian, A.. - : Nature Publishing Group, 2017 BASE Show details 5 Role of N-methyl-D-aspartate receptors in action-based predictive coding deficits in schizophrenia Roach, Brian J.; Krystal, John H.; Reinhart, Robert M.G.. - : Elsevier, 2017 BASE Show details 6 A functional analysis of two transdiagnostic, emotion-focused interventions on nonsuicidal self-injury Bentley, Kate H.; Sauer-Zavala, Shannon; Nock, Matthew K.. - : American Psychological Association, 2017 BASE Show details 7 Co-occurrence frequency evaluated with large language corpora boosts semantic priming effects Brunellière, Angèle; Perre, Laetitia; Tran, ThiMai... In: Quarterly journal of experimental psychology (2006) ; https://hal.univ-lille.fr/hal-01911765 ; Quarterly journal of experimental psychology (2006), 2017, 70 (9), pp.1922--1934. ⟨10.1080/17470218.2016.1215479⟩ (2017) BASE Show details 8 Self-help and help-seeking for communication disability in Ghana: implications for the development of communication disability rehabilitation services. Wylie, Karen; McAllister, Lindy; Davidson, Bronwyn. - 2017 BASE Show details 9 A systematic review of concepts related to women's empowerment in the perinatal period and their associations with perinatal depressive symptoms and premature birth Garcia, Esmeralda R; Yim, Ilona S In: Garcia, Esmeralda R; & Yim, Ilona S. (2017). A systematic review of concepts related to women's empowerment in the perinatal period and their associations with perinatal depressive symptoms and premature birth. BMC PREGNANCY AND CHILDBIRTH, 17(Suppl 2), 347. doi:10.1186/s12884-017-1495-1. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9141q8m0 (2017) BASE Show details 10 Tone Attrition in Mandarin Speakers of Varying English Proficiency. Quam, Carolyn; Creel, Sarah C In: Journal of speech, language, and hearing research : JSLHR, vol 60, iss 2 (2017) BASE Show details 11 A systematic review of concepts related to women's empowerment in the perinatal period and their associations with perinatal depressive symptoms and premature birth. Garcia, Esmeralda R; Yim, Ilona S In: BMC pregnancy and childbirth, vol 17, iss Suppl 2 (2017) BASE Show details 12 Electro-Tactile Stimulation Enhances Cochlear Implant Speech Recognition in Noise. Huang, Juan; Sheffield, Benjamin; Lin, Payton... In: Scientific reports, vol 7, iss 1 (2017) BASE Show details 13 Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease. Elahi, Fanny M; Marx, Gabe; Cobigo, Yann; Staffaroni, Adam M; Kornak, John; Tosun, Duygu; Boxer, Adam L; Kramer, Joel H; Miller, Bruce L; Rosen, Howard J. - : eScholarship, University of California, 2017 Abstract: BackgroundDegradation of white matter microstructure has been demonstrated in frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD). In preparation for clinical trials, ongoing studies are investigating the utility of longitudinal brain imaging for quantification of disease progression. To date only one study has examined sample size calculations based on longitudinal changes in white matter integrity in FTLD.ObjectiveTo quantify longitudinal changes in white matter microstructural integrity in the three canonical subtypes of frontotemporal dementia (FTD) and AD using diffusion tensor imaging (DTI).Methods60 patients with clinical diagnoses of FTD, including 27 with behavioral variant frontotemporal dementia (bvFTD), 14 with non-fluent variant primary progressive aphasia (nfvPPA), and 19 with semantic variant PPA (svPPA), as well as 19 patients with AD and 69 healthy controls were studied. We used a voxel-wise approach to calculate annual rate of change in fractional anisotropy (FA) and mean diffusivity (MD) in each group using two time points approximately one year apart. Mean rates of change in FA and MD in 48 atlas-based regions-of-interest, as well as global measures of cognitive function were used to calculate sample sizes for clinical trials (80% power, alpha of 5%).ResultsAll FTD groups showed statistically significant baseline and longitudinal white matter degeneration, with predominant involvement of frontal tracts in the bvFTD group, frontal and temporal tracts in the PPA groups and posterior tracts in the AD group. Longitudinal change in MD yielded a larger number of regions with sample sizes below 100 participants per therapeutic arm in comparison with FA. SvPPA had the smallest sample size based on change in MD in the fornix (n=41 participants per study arm to detect a 40% effect of drug), and nfvPPA and AD had their smallest sample sizes based on rate of change in MD within the left superior longitudinal fasciculus (n=49 for nfvPPA, and n=23 for AD). BvFTD generally showed the largest sample size estimates (minimum n=140 based on MD in the corpus callosum). The corpus callosum appeared to be the best region for a potential study that would include all FTD subtypes. Change in global measure of functional status (CDR box score) yielded the smallest sample size for bvFTD (n=71), but clinical measures were inferior to white matter change for the other groups.ConclusionsAll three of the canonical subtypes of FTD are associated with significant change in white matter integrity over one year. These changes are consistent enough that drug effects in future clinical trials could be detected with relatively small numbers of participants. While there are some differences in regions of change across groups, the genu of the corpus callosum is a region that could be used to track progression in studies that include all subtypes. Keyword: 2.1 Biological and endogenous factors; Acquired Cognitive Impairment; AD; Aged; Aging; Alzheimer Disease; Alzheimer's Disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer's Disease Related Dementias (ADRD); Behavioral and Social Science; Behavioral variant FTD; Biomedical Imaging; Brain; Brain Disorders; Clinical Research; Clinical trial; Clinical Trials and Supportive Activities; Cross-Sectional Studies; Dementia; Diffusion Tensor Imaging; DTI; Female; Frontotemporal Dementia; Frontotemporal Dementia (FTD); FTD; Humans; Longitudinal; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Neurodegenerative; Neurological; Neurosciences; Primary progressive aphasia; Rare Diseases; Retrospective Studies; Sample Size; White Matter; White matter integrity URL: https://escholarship.org/uc/item/36t974qr BASE Hide details 14 Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease. Elahi, Fanny M; Marx, Gabe; Cobigo, Yann. - : eScholarship, University of California, 2017 BASE Show details 15 Data-driven classification of patients with primary progressive aphasia. Nestor, Peter J; Sajjadi, Seyed Ahmad; Patterson, Karalyn. - : eScholarship, University of California, 2017 BASE Show details 16 A neural network underlying intentional emotional facial expression in neurodegenerative disease. Gola, Kelly A; Shany-Ur, Tal; Pressman, Peter. - : eScholarship, University of California, 2017 BASE Show details 17 Emotion detection deficits and changes in personality traits linked to loss of white matter integrity in primary progressive aphasia. Multani, Namita; Galantucci, Sebastiano; Wilson, Stephen M. - : eScholarship, University of California, 2017 BASE Show details 18 Auditory Deprivation Does Not Impair Executive Function, But Language Deprivation Might: Evidence From a Parent-Report Measure in Deaf Native Signing Children. Hall, Matthew L; Eigsti, Inge-Marie; Bortfeld, Heather... In: Journal of deaf studies and deaf education, vol 22, iss 1 (2017) BASE Show details 19 A neural network underlying intentional emotional facial expression in neurodegenerative disease. Gola, Kelly A; Shany-Ur, Tal; Pressman, Peter. - : eScholarship, University of California, 2017 BASE Show details 20 Finding meaning in a noisy world: exploring the effects of referential ambiguity and competition on 2·5-year-olds' cross-situational word learning. Bunce, John P; Scott, Rose M In: Journal of child language, vol 44, iss 3 (2017) BASE Show details Page: 1 2 3 4 5 6

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