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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 14 of 14 1 Emotion detection deficits and changes in personality traits linked to loss of white matter integrity in primary progressive aphasia. Multani, Namita; Galantucci, Sebastiano; Wilson, Stephen M; Shany-Ur, Tal; Poorzand, Pardis; Growdon, Matthew E; Jang, Jung Yun; Kramer, Joel H; Miller, Bruce L; Rankin, Katherine P; Gorno-Tempini, Maria Luisa; Tartaglia, Maria Carmela. - : eScholarship, University of California, 2017 Abstract: Non-cognitive features including personality changes are increasingly recognized in the three PPA variants (semantic-svPPA, non fluent-nfvPPA, and logopenic-lvPPA). However, differences in emotion processing among the PPA variants and its association with white matter tracts are unknown. We compared emotion detection across the three PPA variants and healthy controls (HC), and related them to white matter tract integrity and cortical degeneration. Personality traits in the PPA group were also examined in relation to white matter tracts. Thirty-three patients with svPPA, nfvPPA, lvPPA, and 32 HC underwent neuropsychological assessment, emotion evaluation task (EET), and MRI scan. Patients' study partners were interviewed on the Clinical Dementia Rating Scale (CDR) and completed an interpersonal traits assessment, the Interpersonal Adjective Scale (IAS). Diffusion tensor imaging of uncinate fasciculus (UF), superior longitudinal fasciculus (SLF) and inferior longitudinal fasciculus (ILF), and voxel-based morphometry to derive gray matter volumes for orbitofrontal cortex (OFC), anterior temporal lobe (ATL) regions were performed. In addition, gray matter volumes of white matter tract-associated regions were also calculated: inferior frontal gyrus (IFG), posterior temporal lobe (PTL), inferior parietal lobe (IPL) and occipital lobe (OL). ANCOVA was used to compare EET performance. Partial correlation and multivariate linear regression were conducted to examine association between EET and neuroanatomical regions affected in PPA. All three variants of PPA performed significantly worse than HC on EET, and the svPPA group was least accurate at recognizing emotions. Performance on EET was related to the right UF, SLF, and ILF integrity. Regression analysis revealed EET performance primarily relates to the right UF integrity. The IAS subdomain, cold-hearted, was also associated with right UF integrity. Disease-specific emotion recognition and personality changes occur in the three PPA variants and are likely associated with disease-specific neuroanatomical changes. Loss of white matter integrity contributes as significantly as focal atrophy in behavioral changes in PPA. Keyword: Aged; Aphasia; Atrophy; Cerebral Cortex; Diffusion Tensor Imaging; Emotion detection; Emotions; Facial Expression; Facial Recognition; Female; Humans; Male; Middle Aged; Neurosciences; Personality; Primary Progressive; Primary progressive aphasia; Social cognition; Social Perception; White Matter URL: https://escholarship.org/uc/item/06j988x8 BASE Hide details 2 Data-driven regions of interest for longitudinal change in three variants of frontotemporal lobar degeneration. Binney, Richard J; Pankov, Aleksandr; Marx, Gabriel... In: Brain and behavior, vol 7, iss 4 (2017) BASE Show details 3 Observing conversational laughter in frontotemporal dementia. Pressman, Peter S; Simpson, Michaela; Gola, Kelly... In: Journal of neurology, neurosurgery, and psychiatry, vol 88, iss 5 (2017) BASE Show details 4 Emotion detection deficits and changes in personality traits linked to loss of white matter integrity in primary progressive aphasia. Multani, Namita; Galantucci, Sebastiano; Wilson, Stephen M. - : eScholarship, University of California, 2017 BASE Show details 5 Observing conversational laughter in frontotemporal dementia. Pressman, Peter S; Simpson, Michaela; Gola, Kelly... In: Journal of neurology, neurosurgery, and psychiatry, vol 88, iss 5 (2017) BASE Show details 6 Data-driven regions of interest for longitudinal change in three variants of frontotemporal lobar degeneration. Binney, Richard J; Pankov, Aleksandr; Marx, Gabriel... In: Brain and behavior, vol 7, iss 4 (2017) BASE Show details 7 Early changes in brain structure correlate with language outcomes in children with neonatal encephalopathy. Shapiro, Kevin A; Kim, Hosung; Mandelli, Maria Luisa. - : eScholarship, University of California, 2017 BASE Show details 8 Clinicopathologic correlations and neuroimaging biomarkers in primary progressive aphasia Santos Santos, Miguel Ángel. - : Universitat Autònoma de Barcelona, 2017 In: TDX (Tesis Doctorals en Xarxa) (2017) BASE Show details 9 Distinct spatiotemporal patterns of neuronal functional connectivity in primary progressive aphasia variants Ranasinghe, Kamalini G; Hinkley, Leighton B; Beagle, Alexander J. - : Oxford University Press, 2017 BASE Show details 10 Visuospatial Functioning in the Primary Progressive Aphasias Watson, Christa L.; Possin, Katherine; Allen, I. Elaine. - 2017 BASE Show details 11 Typical and atypical pathology in primary progressive aphasia variants Spinelli, Edoardo G; Mandelli, Maria Luisa; Miller, Zachary A. - 2017 BASE Show details 12 Emotion detection deficits and changes in personality traits linked to loss of white matter integrity in primary progressive aphasia Multani, Namita; Galantucci, Sebastiano; Wilson, Stephen M.. - : Elsevier, 2017 BASE Show details 13 Focal temporal pole atrophy and network degeneration in semantic variant primary progressive aphasia Collins, Jessica A.; Montal, Victor; Hochberg, Daisy. - : Oxford University Press, 2017 BASE Show details 14 Clinicopathologic correlations and neuroimaging biomarkers in primary progressive aphasia Santos Santos, Miguel Ángel; Universitat Autònoma de Barcelona. Departament de Medicina. - 2017 BASE Show details

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