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Structural, Microstructural, and Metabolic Alterations in Primary Progressive Aphasia Variants
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In: ISSN: 1664-2295 ; Frontiers in Neurology ; https://hal.inria.fr/hal-01897015 ; Frontiers in Neurology, Frontiers, 2018, 9, ⟨10.3389/fneur.2018.00766⟩ (2018)
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The structure of the mental lexicon: what primary progressive aphasias reveal
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In: ISSN: 0028-3932 ; EISSN: 1873-3514 ; Neuropsychologia ; https://hal.inria.fr/hal-01672932 ; Neuropsychologia, Elsevier, 2018, 109, pp.107-115. ⟨10.1016/j.neuropsychologia.2017.12.018⟩ (2018)
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Structural, microstructural and metabolic alterations in Primary Progressive Aphasia variants
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In: Annual meeting of the Organization for Human Brain Mapping - OHBM 2018 ; https://hal.inria.fr/hal-01764289 ; Annual meeting of the Organization for Human Brain Mapping - OHBM 2018, Jun 2018, Singapore, Singapore (2018)
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Prevalence of amyloid‐β pathology in distinct variants of primary progressive aphasia
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In: ISSN: 0364-5134 ; EISSN: 1531-8249 ; Annals of Neurology ; https://www.hal.inserm.fr/inserm-02749861 ; Annals of Neurology, Wiley, 2018, 84 (5), pp.729-740. ⟨10.1002/ana.25333⟩ (2018)
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Parietal involvement in the semantic variant of primary progressive aphasia with Alzheimer's disease CSF profile
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Bera, Géraldine; Migliaccio, Raffaella; Michelin, Thibaut; Lamari, Foudil; Ferrieux, Sophie; Nogues, Marie; Bertin, Hugo; Habert, Marie Odile; Dubois, Bruno; Teichmann, Marc; Kas, Aurélie
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In: ISSN: 1387-2877 ; Journal of Alzheimer's Disease ; https://hal.sorbonne-universite.fr/hal-01928504 ; Journal of Alzheimer's Disease, IOS Press, 2018, 66 (1), pp.271 - 280. ⟨10.3233/JAD-180087⟩ (2018)
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Abstract:
International audience ; Semantic variant of primary progressive aphasia (svPPA) is typically associated with non-Alzheimer’s disease (AD) pathology. However, some anatomopathological studies have found AD lesions in those patients. We compared brain perfusion SPECT of 18 svPPA patients with cerebrospinal fluid (CSF) biomarkers indicative of non-AD pathology (svPPA-nonAD) and three svPPA patients with CSF biomarkers indicative of underlying AD (svPPA-AD). All svPPA patients had severe left temporopolar hypoperfusion. SvPPA-nonAD had additional anterior cingulate and mediofrontal hypoperfusion, whereas svPPA-AD had greater left parietal and posterior cingulate involvement. Parietal damage in svPPA constitutes a biomarker for underlying Alzheimer pathology thus refining the classification of this PPA variant.
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Keyword:
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology; [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]; [SDV]Life Sciences [q-bio]; Alzheimer’s disease; atypical AD; cerebrospinal fluid examination; parietal lobe; semantic variant of primary progressive aphasia; single photon emission computed tomography
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URL: https://doi.org/10.3233/JAD-180087 https://hal.sorbonne-universite.fr/hal-01928504 https://hal.sorbonne-universite.fr/hal-01928504/file/MIGLIACCIO_Lara.pdf https://hal.sorbonne-universite.fr/hal-01928504/document
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An Automated Pipeline for the Analysis of PET Data on the Cortical Surface
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In: ISSN: 1662-5196 ; Frontiers in Neuroinformatics ; https://hal.inria.fr/hal-01950933 ; Frontiers in Neuroinformatics, Frontiers, 2018, 12, ⟨10.3389/fninf.2018.00094⟩ (2018)
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