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Anomalous morphology in left hemisphere motor and premotor cortex of children who stutter
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Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.
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In: JAMA neurology, vol 75, iss 3 (2018)
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Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.
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In: JAMA neurology, vol 75, iss 3 (2018)
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Neuroscientific insights into the development of analogical reasoning.
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In: Developmental science, vol 21, iss 2 (2018)
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Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes.
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In: Nature neuroscience, vol 21, iss 12 (2018)
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Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes.
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In: Nature neuroscience, vol 21, iss 12 (2018)
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Use of Vitamin K Antagonists and Brain Morphological Changes in Older Adults: An Exposed/Unexposed Voxel-Based Morphometric Study
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In: ISSN: 1421-9824 ; Dementia and geriatric cognitive disorders ; https://hal.univ-angers.fr/hal-02869144 ; Dementia and geriatric cognitive disorders, 2018, 45, pp.18-26. ⟨10.1159/000485793⟩ ; https://www.karger.com/Article/Abstract/485793 (2018)
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Abstract:
International audience ; BACKGROUND: Vitamin K antagonists (VKAs) are commonly used for their role in haemostasis by interfering with the vitamin K cycle. Since vitamin K also participates in brain physiology, this voxel-based morphometric study aimed to determine whether the duration of exposure to VKAs correlated with focal brain volume reduction in older adults. METHODS: In this exposed/unexposed (1: 2) study nested within the GAIT (Gait and Alzheimer Interactions Tracking) cohort, 18 participants exposed to VKA (mean age 75 ± 5 years; 33.3% female; mean exposure 2,122 ± 1,799 days) and 36 matched participants using no VKA (mean age 75 ± 5 years; 33.3% female) underwent MRI scanning of the brain. Cortical grey and white matter volumes were automatically segmented using statistical parametric mapping. Age, gender, educational level, history of atrial fibrillation, type of MRI, and total intracranial volume were included as covariables. RESULTS: The duration of exposure to VKA correlated inversely across the whole brain with the subvolumes of two clusters in the grey matter (right frontal inferior operculum and right precuneus) and one cluster in the white matter (left middle frontal gyrus). In contrast, the grade of white matter hyperintensities did not differ according to the use of VKA. CONCLUSION: We found focal atrophies in older adults exposed to VKA. These findings provide new insights elucidating the effects of VKAs on brain health and function in older adults.
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Keyword:
80 and over; [SHS]Humanities and Social Sciences; Age Factors; Aged; Alzheimer Disease; Anticoagulants; Brain; Cohort Studies; Computer-Assisted; Cross-Sectional Studies; Educational Status; Female; Gait Disorders; Gray Matter; Humans; Image Processing; Magnetic Resonance Imaging; Male; Neurologic; Sex Factors; Vitamin K; White Matter
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URL: https://hal.univ-angers.fr/hal-02869144
https://doi.org/10.1159/000485793
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Neural Prediction Errors Distinguish Perception and Misperception of Speech. ...
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Phase Entrainment of Brain Oscillations Causally Modulates Neural Responses to Intelligible Speech. ...
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Neural Prediction Errors Distinguish Perception and Misperception of Speech.
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| 11 |
Phase Entrainment of Brain Oscillations Causally Modulates Neural Responses to Intelligible Speech.
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