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1
Exploring how prison-based drug rehabilitation programming shapes racial disparities in substance use disorder recovery.
In: Social science & medicine (1982), vol 199, iss C (2018)
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2
Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes.
In: Nature neuroscience, vol 21, iss 12 (2018)
Abstract: Heterogeneity in early language development in autism spectrum disorder (ASD) is clinically important and may reflect neurobiologically distinct subtypes. Here, we identified a large-scale association between multiple coordinated blood leukocyte gene coexpression modules and the multivariate functional neuroimaging (fMRI) response to speech. Gene coexpression modules associated with the multivariate fMRI response to speech were different for all pairwise comparisons between typically developing toddlers and toddlers with ASD and poor versus good early language outcome. Associated coexpression modules were enriched in genes that are broadly expressed in the brain and many other tissues. These coexpression modules were also enriched in ASD-associated, prenatal, human-specific, and language-relevant genes. This work highlights distinctive neurobiology in ASD subtypes with different early language outcomes that is present well before such outcomes are known. Associations between neuroimaging measures and gene expression levels in blood leukocytes may offer a unique in vivo window into identifying brain-relevant molecular mechanisms in ASD.
Keyword: 1.1 Normal biological development and functioning; 2.1 Biological and endogenous factors; Autism; Autism Spectrum Disorder; Brain; Brain Disorders; Brain Mapping; Child; Clinical Research; Cognitive Sciences; Female; Genetics; Humans; Infant; Intellectual and Developmental Disabilities (IDD); Language; Leukocytes; Magnetic Resonance Imaging; Male; Mental Health; Neuroimaging; Neurological; Neurology & Neurosurgery; Neurosciences; Pediatric; Preschool; Psychology; Speech; Transcriptome
URL: https://escholarship.org/uc/item/2n39p5qz
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3
Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes.
In: Nature neuroscience, vol 21, iss 12 (2018)
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4
Developmental social communication deficits in the Shank3 rat model of phelan-mcdermid syndrome and autism spectrum disorder.
In: Autism research : official journal of the International Society for Autism Research, vol 11, iss 4 (2018)
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5
Gaze to faces across interactive contexts in infants at heightened risk for autism.
In: Autism : the international journal of research and practice, vol 22, iss 6 (2018)
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6
Children with mixed developmental language disorder have more insecure patterns of attachment.
In: BMC psychology, vol. 6, no. 1, pp. 54 (2018)
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