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Hits 1 – 20 of 217
1
Vaccination coverage in the context of the emerging Yellow Fever threat in French Guiana
Flamand, Claude
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Bailly, Sarah
;
Fritzell, Camille
...
In: ISSN: 1935-2727 ; EISSN: 1935-2735 ; PLoS Neglected Tropical Diseases ; https://hal-pasteur.archives-ouvertes.fr/pasteur-02935032 ; PLoS Neglected Tropical Diseases, Public Library of Science, 2019, 13 (8), pp.e0007661. ⟨10.1371/journal.pntd.0007661⟩ (2019)
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2
Youth-Sized Lab Coats: When Children Become Doctors Through Adolescent Healthcare Brokering
Russell, Lindsey
In: Social Sciences (2019)
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3
« Il faut dire, on dit, ça veut dire… » : étude des formes et fonctions des interventions métalangagières en situation d’intervention orthophonique
Da Silva, Christine
In: ISSN: 2248-2547 ; EISSN: 2284-5437 ; Studii de lingvistică ; https://hal.univ-lorraine.fr/hal-02962402 ; Studii de lingvistică, Editura Universităţii din Oradea, Oradea, România, 2019, 9 (2), pp.153-176 (2019)
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4
Comparing Traditional and Tablet-Based Intervention for Children With Speech Sound Disorders: A Randomized Controlled Trial
Jesus, L. M. T.
;
Martinez, J.
;
Santos, J.
. - : American Speech-Language-Hearing Association, 2019
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5
Sign language development in deaf children with additional needs
Herman, R.
;
Shield, A.
;
Morgan, G.
. - : Nova Sciences Publishers, 2019
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6
The effectiveness of classroom vocabulary intervention for adolescents with language disorder
Lowe, H.
;
Henry, L.
;
Joffe, V.
. - : American Speech-Language-Hearing Association, 2019
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7
Parental Reflective Functioning and Children’s Emergent Reading Skills: ERP and longitudinal behavioral measures
Lau, Airey Nga-Lui
. - 2019
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8
The Understanding of Communicative Intentions in Children with Severe-to-Profound Hearing Loss
Kelly, C.
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Morgan, G.
;
Freeth, M.
. - : Oxford University Press, 2019
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9
Understanding Pretend Emotions in Children Who Are Deaf and Hard of Hearing
Sidera, F.
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Morgan, G.
;
Serrat, E.
. - : Oxford University Press, 2019
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10
The Early Sociocognitive Battery: a clinical tool for early identification of children at risk for social communication difficulties and ASD?
Roy, P.
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Chiat, S.
. - : Wiley, 2019
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11
Aspects of Joint Attention in Autism Spectrum Disorder: Links to Sensory Processing, Social Competence, Maternal Attention, and Contextual Factors
Dakopolos, Andrew Jacob
. - 2019
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12
Functional near-infrared spectroscopy as a tool for assessing speech and spoken language processing in pediatric and adult cochlear implant users.
Bortfeld, Heather
In: Developmental psychobiology, vol 61, iss 3 (2019)
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13
Maternal discourse continuity and infants' actions organize 12-month-olds' language exposure during object play.
Chang, Lucas M
;
Deák, Gedeon O
In: Developmental science, vol 22, iss 3 (2019)
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14
Cake or broccoli? Recency biases children's verbal responses.
Sumner, Emily
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DeAngelis, Erika
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Hyatt, Mara
...
In: PloS one, vol 14, iss 6 (2019)
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15
Multilingual assessment of early child development: Analyses from repeated observations of children in Kenya.
Knauer, Heather
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Kariger, Patricia
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Jakiela, Pamela
...
In: Developmental Science, vol 22, iss 5 (2019)
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16
In Between Language and Health: Children’s experiences brokering language, culture, and information for health
Martinez, Krissia
. - : eScholarship, University of California, 2019
In: Martinez, Krissia. (2019). In Between Language and Health: Children’s experiences brokering language, culture, and information for health. UCLA: Education 0249. Retrieved from: http://www.escholarship.org/uc/item/7j77f2ms (2019)
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17
Children's biobehavioral reactivity to challenge predicts DNA methylation in adolescence and emerging adulthood.
Goodman, Sarah J
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Roubinov, Danielle S
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Bush, Nicole R
...
In: Developmental science, vol 22, iss 2 (2019)
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18
Mobile Screen Technologies and Parents of Young Children: Investigating Diverse Parents’ Attitudes, Beliefs, and their Interactions with Children
Ochoa, Wendy
. - : eScholarship, University of California, 2019
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19
Metformin treatment in young children with fragile X syndrome.
Biag, Hazel Maridith B
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Potter, Laura A
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Wilkins, Victoria
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Afzal, Sumra
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Rosvall, Alexis
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Salcedo-Arellano, Maria Jimena
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Rajaratnam, Akash
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Manzano-Nunez, Ramiro
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Schneider, Andrea
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Tassone, Flora
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Rivera, Susan M
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Hagerman, Randi J
In: Molecular genetics & genomic medicine, vol 7, iss 11 (2019)
Abstract:
BackgroundMetformin is a drug commonly used in individuals with type 2 diabetes, obesity, and impaired glucose tolerance. It has a strong safety profile in both children and adults. Studies utilizing the Drosophila model and knock out mouse model of fragile X syndrome (FXS) have found metformin to rescue memory, social novelty deficits, and neuroanatomical abnormalities. These studies provided preliminary evidence that metformin could be used as a targeted treatment for the cognitive and behavioral problems associated with FXS. Previously, a case series of children and adults with FXS treated with metformin demonstrated improvements in irritability, social responsiveness, language, and hyperactivity.MethodsHere, we present nine children with FXS between 2 and 7years of age who were treated clinically with metformin and monitored for behavioral and metabolic changes.ResultsParent reports and developmental testing before and after metformin are presented. There were improvements in language development and behavior (such as lethargy and stereotypy) in most of the patients.ConclusionThese results support the need for a controlled trial of metformin in children with FXS under 7years old whose brains are in a critical developmental window and thus may experience a greater degree of clinical benefit from metformin.
Keyword:
6.1 Pharmaceuticals
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Basic Behavioral and Social Science
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Behavioral and Social Science
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Brain Disorders
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Child
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Clinical Sciences
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Diabetes
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FMR1
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Fragile X Syndrome
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Hypoglycemic Agents
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Intellectual and Developmental Disabilities (IDD)
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Medicinal and Biomolecular Chemistry
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Metformin
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Neurodevelopmental Disorders
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Orphan Drug
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Prognosis
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Rare Diseases
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targeted treatments
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translational medicine
URL:
https://escholarship.org/uc/item/6vz0b2jm
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20
Early life risk factors of motor, cognitive and language development: a pooled analysis of studies from low/middle-income countries.
Sania, Ayesha
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Sudfeld, Christopher R
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Danaei, Goodarz
...
In: BMJ open, vol 9, iss 10 (2019)
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