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Start with “Why,” but only if you have to: The strategic framing of novel ideas across different audiences
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A Model of the Production Effect over the Short-Term: The Cost of Relative Distinctiveness
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Two clinical markers for DLD in monolingual Italian speakers: what can they tell us about second language learners with DLD?
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An aphasia research agenda–a consensus statement from the collaboration of aphasia trialists
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Decoding verbal working memory representations of Chinese characters from Broca's area
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Creating a novel approach to discourse treatment through coproduction with people with aphasia and speech and language therapists
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Lesion site and therapy time predict responses to a therapy for anomia after stroke: a prognostic model development study
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Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: the RELEASE database of aphasia after stroke
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Scoping opinion: Speech and language therapists' views on extending their role to the urgent ear, nose and throat pathway.
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Dosage, Intensity, and Frequency of Language Therapy for Aphasia: A Systematic Review-Based, Individual Participant Data Network Meta-Analysis
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Leemann, B.; Nilipour, R.; Rose, M. L.; Stahl, B.; Kong, A. P.; Williams, L. R.; Price, C.; Ruiter, M. B.; Papathanasiou, I.; Hawkins, N.; Howard, D.; Hilari, K.; Paik, N-J.; Khedr, E. M.; Rosso, C.; Rubi-Fessen, I.; Palmer, R.; Szaflarski, J. P.; Godecke, E.; Marshall, R. S.; Jesus, L. M. T.; Leff, A. P.; Laganaro, M.; Glize, B.; Jefferies, E.; Cranfill, T. B.; Ralph, M. L.; Brady, M. C.; Horton, S.; van de Sandt-Koenderman, M.; Becker, F.; Patrício, B.; Rochon, E.; Thomas, S.; VandenBerg, K.; Martins, I.; Copland, D.; The REhabilitation and recovery of peopLE with Aphasia after Str; di Pietro-Bachmann, M.; van der Meulen, I.; Bruehl, S.; Laska, A-C.; Noe, E.; Jaecks, P.; Kang, E. K.; Worrall, L.; Ali, M.; Jakovac, T. P.; Lima, R. R.; Wright, H. H.; Enderby, P.; Fillingham, J.; Meinzer, M.; Gandolfi, M.; Brandenburg, C.; MacWhinney, B.; Williams, L. J.; Breitenstein, C.; Bowen, A.; Galli, F. L.; Hinckley, J.; Lorenz, A.; Snell, C.; Kukkonen, T.; Mavis, I.; Kambanaros, M.; Mattioli, F.; Abo, M.. - : Lippincott, Williams & Wilkins, 2021
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Abstract:
BACKGROUND AND PURPOSE: Optimizing speech and language therapy (SLT) regimens for maximal aphasia recovery is a clinical research priority. We examined associations between SLT intensity (hours/week), dosage (total hours), frequency (days/week), duration (weeks), delivery (face to face, computer supported, individual tailoring, and home practice), content, and language outcomes for people with aphasia. METHODS: Databases including MEDLINE and Embase were searched (inception to September 2015). Published, unpublished, and emerging trials including SLT and ≥10 individual participant data on aphasia, language outcomes, and time post-onset were selected. Patient-level data on stroke, language, SLT, and trial risk of bias were independently extracted. Outcome measurement scores were standardized. A statistical inferencing, one-stage, random effects, network meta-analysis approach filtered individual participant data into an optimal model examining SLT regimen for overall language, auditory comprehension, naming, and functional communication pre-post intervention gains, adjusting for a priori-defined covariates (age, sex, time poststroke, and baseline aphasia severity), reporting estimates of mean change scores (95% CI). RESULTS: Data from 959 individual participant data (25 trials) were included. Greatest gains in overall language and comprehension were associated with >20 to 50 hours SLT dosage (18.37 [10.58-26.16] Western Aphasia Battery-Aphasia Quotient; 5.23 [1.51-8.95] Aachen Aphasia Test-Token Test). Greatest clinical overall language, functional communication, and comprehension gains were associated with 2 to 4 and 9+ SLT hours/week. Greatest clinical gains were associated with frequent SLT for overall language, functional communication (3-5+ days/week), and comprehension (4-5 days/week). Evidence of comprehension gains was absent for SLT ≤20 hours, <3 hours/week, and ≤3 days/week. Mixed receptive-expressive therapy, functionally tailored, with prescribed home practice was associated with the greatest overall gains. Relative variance was <30%. Risk of trial bias was low to moderate; low for meta-biases. CONCLUSIONS: Greatest language recovery was associated with frequent, functionally tailored, receptive-expressive SLT, with prescribed home practice at a greater intensity and duration than reports of usual clinical services internationally. These exploratory findings suggest critical therapeutic ranges, informing hypothesis-testing trials and tailoring of clinical services. Registration: URL: https://www.crd.york.ac.uk/PROSPERO/; Unique identifier: CRD42018110947.
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Keyword:
P Philology. Linguistics; RC Internal medicine
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URL: https://openaccess.city.ac.uk/id/eprint/27373/1/STROKEAHA.121.035216.pdf
https://openaccess.city.ac.uk/id/eprint/27373/
https://doi.org/10.1161/STROKEAHA.121.035216
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‘Emotion is of the essence. … Number one priority’: A nested qualitative study exploring psychosocial adjustment to stroke and aphasia
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"Loneliness can also kill:" a qualitative exploration of outcomes and experiences of the SUPERB peer-befriending scheme for people with aphasia and their significant others
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A systematic review of language and communication intervention research delivered in groups to older adults living in care homes
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Predictors of wellbeing in young adults with aphasia and young adults with developmental language disorder
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The interplay between early social interaction, language and executive function development in deaf and hearing infants
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A randomised controlled feasibility trial of music-assisted language telehealth intervention for minimally verbal autistic children-the MAP study protocol
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UK Speech & Language Therapists working in school-aged children dysphagia practice. Impact of Covid19 on clinical practice: A survey
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