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Involvement of Laryngopharyngeal Reflux in Select Nonfunctional Laryngeal Diseases: A Systematic Review
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In: ISSN: 0886-4470 ; Archives of Otolaryngology Head and Neck Surgery ; https://halshs.archives-ouvertes.fr/halshs-03379916 ; Archives of Otolaryngology Head and Neck Surgery, American Medical Association, 2021, 164 (1), pp.37-48. ⟨10.1177/0194599820933209⟩ (2021)
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Abstract:
International audience ; Objectives To investigate the existing published evidence supporting the role of laryngopharyngeal reflux (LPR) in the development of the select nonfunctional laryngeal diseases of laryngotracheal stenosis, granuloma, leukoplakia, and laryngeal infections Data Sources PubMed, Cochrane Library, and Scopus. Review Methods A systematic review was performed by 3 independent investigators for studies providing information about the prevalence and role of LPR in the development of laryngotracheal stenosis, granuloma, leukoplakia, and laryngeal infections. Diagnostic criteria and clinical outcome evaluation of included studies were analyzed with PRISMA criteria. Results Of the 64 relevant publications, 27 clinical and 4 basic science studies were included. Ten studies used objective reliable examinations for LPR diagnosis (eg, dual- or triple-probe or oropharyngeal pH monitoring, multichannel intraluminal impedance–pH monitoring, or pepsin detection). According to the bias analysis and the results of studies, the association between LPR and laryngotracheal stenosis, leukoplakia, laryngeal papillomatosis, or vocal fold granuloma remains poorly demonstrated. There is a notable heterogeneity among included studies regarding their inclusion criteria, diagnostic methods, and clinical outcome evaluation. Although some experimental findings support the involvement of bile salts and other gastroduodenal proteins active in alkaline pH, no included clinical studies assessed the role of nonacid and mixed reflux through multichannel intraluminal impedance–pH monitoring. Conclusion The involvement of LPR in the development of leukoplakia, laryngotracheal stenosis, vocal fold granuloma, and laryngeal papillomatosis is currently not demonstrated. The potential relationship between LPR and these select nonfunctional laryngeal diseases must be confirmed through future clinical and experimental studies considering acid, nonacid, and mixed LPR.
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Keyword:
[SHS.LANGUE]Humanities and Social Sciences/Linguistics
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URL: https://halshs.archives-ouvertes.fr/halshs-03379916
https://doi.org/10.1177/0194599820933209
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Influence of Age and Sex on Clinical and Therapeutic Features of Laryngopharyngeal Reflux
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In: ISSN: 0886-4470 ; Archives of Otolaryngology Head and Neck Surgery ; https://halshs.archives-ouvertes.fr/halshs-03379981 ; Archives of Otolaryngology Head and Neck Surgery, American Medical Association, 2021, pp.019459982110202. ⟨10.1177/01945998211020284⟩ (2021)
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Development and Validation of the Short Version of the Reflux Symptom Score: Reflux Symptom Score–12
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In: ISSN: 0886-4470 ; Archives of Otolaryngology Head and Neck Surgery ; https://halshs.archives-ouvertes.fr/halshs-03379930 ; Archives of Otolaryngology Head and Neck Surgery, American Medical Association, 2021, 164 (1), pp.166-174. ⟨10.1177/0194599820941003⟩ (2021)
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Explaining redundancy in linguistic morphology: evidence from Yam and Kartvelian ...
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Towards Protecting Vital Healthcare Programs by Extracting Actionable Knowledge from Policy ...
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Charting a global research strategy for progressive MS—An international progressive MS Alliance proposal
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In: Mult Scler (2021)
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The Downstream Effects of Teacher Well-Being Programs: Improvements in Teachers' Stress, Cognition and Well-Being Benefit Their Students
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In: Front Psychol (2021)
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Development and evaluation of an interprofessional student-led influenza vaccination clinic for medical, nursing and pharmacy students
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In: Pharm Pract (Granada) (2021)
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Patient/Consumer Codesign and Coproduction of Medical Curricula: A Possible Path Toward Improved Cultural Competence and Reduced Health Disparity
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In: Test Series for Scopus Harvesting 2021 (2021)
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The Impact of Songs and Gestures on Bilingual Leaning in a Montessori Classroom
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