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Primary Progressive Aphasia Associated With GRN Mutations: New Insights Into the Non-amyloid Logopenic Variant
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In: ISSN: 0028-3878 ; EISSN: 1526-632X ; Neurology ; https://hal.archives-ouvertes.fr/hal-03281660 ; Neurology, American Academy of Neurology, 2021, ⟨10.1212/wnl.0000000000012174⟩ (2021)
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Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification.
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Neural dynamics of semantic categorization in semantic variant of primary progressive aphasia.
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Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
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In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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Social Behavior Observer Checklist: Patterns of Spontaneous Behaviors Differentiate Patients With Neurodegenerative Disease From Healthy Older Adults.
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Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification.
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| 7 |
What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
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| 8 |
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
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Staffaroni, Adam M; Weintraub, Sandra; Rascovsky, Katya; Rankin, Katherine P; Taylor, Jack; Fields, Julie A; Casaletto, Kaitlin B; Hillis, Argye E; Lukic, Sladjana; Gorno-Tempini, Maria Luisa; Heuer, Hilary; Teylan, Merilee A; Kukull, Walter A; Miller, Bruce L; Boeve, Bradley F; Rosen, Howard J; Boxer, Adam L; Kramer, Joel H
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In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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Abstract:
IntroductionThe Frontotemporal Lobar Degeneration Module (FTLD-MOD) includes a neuropsychological battery designed to assess the clinical features of FTLD, although much is unknown about its utility. We investigated FTLD-MOD and Uniform Data Set 3.0 (UDS) language tests for differential diagnosis and disease monitoring.MethodsLinear regressions compared baseline performances in 1655 National Alzheimer's Coordinating Center participants (behavioral variant frontotemporal dementia (bvFTD, n=612), semantic variant primary progressive aphasia (svPPA, n=168), non-fluent/agrammatic variant PPA (nfvPPA, n=168), logopenic variant PPA (lvPPA, n=109), and controls (n=581)). Sample sizes to detect treatment effects were estimated using longitudinal data.ResultsAmong PPAs, the FTLD-MOD language tasks and UDS Multilingual Naming Test accurately discriminated svPPA. Number Span Forward best discriminated lvPPA; Phonemic:Semantic Fluency ratio was excellent for nfvPPA classification. UDS fluency and naming measures required the smallest sample size to detect meaningful change.DiscussionThe FTLD-MOD and UDS differentiated among PPA subtypes. UDS 3.0 measures performed best for longitudinal monitoring.
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Keyword:
Acquired Cognitive Impairment; Aging; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer's Disease Related Dementias (ADRD); Aphasia; Brain Disorders; Clinical Research; clinical trials; Clinical Trials and Supportive Activities; cognition; Dementia; differential diagnosis; endpoints; frontotemporal dementia; Frontotemporal Dementia (FTD); FTLD module; Genetics; longitudinal; Neurodegenerative; neuropsychology; Neurosciences; primary progressive aphasia; Rare Diseases; speech
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URL: https://escholarship.org/uc/item/31v6d3qh
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| 9 |
What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
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| 10 |
Home Visit Based Mindfulness Intervention for Vietnamese American Dementia Family Caregivers: A Pilot Feasibility Study.
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In: Asian/Pacific Island nursing journal, vol 5, iss 4 (2021)
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| 11 |
Have You Heard About Hearing Loss, Hearing Aid Use, And Cognitive Decline? Relationships, Mechanisms, And A Proposed Investigation Using Event-Related Potentials
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The cognitive and neurological effects of bilingualism on the progression of dementia: a longitudinal study ...
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| 13 |
MONDAY OR FRIDAY? UNDERSTANDING TIME THROUGH SPATIAL EXPERIENCE ...
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Argument structure taxonomy based 269 verb picture corpus in Kannada ...
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| 15 |
Cross-cultural cognitive assessment of dementia: a meta-analysis of the impact of illiteracy on dementia screening and an evaluation of a transcultural short-term memory assessment ...
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Conceptual framework for the definition of preclinical and prodromal frontotemporal dementia. ...
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| 17 |
Longitudinal association of intraindividual variability with cognitive decline and dementia: A meta-analysis
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In: Research outputs 2014 to 2021 (2021)
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| 18 |
“Hard to Say, Hard to Understand, Hard to Live”: Possible Associations between Neurologic Language Impairments and Suicide Risk
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In: Brain Sciences; Volume 11; Issue 12; Pages: 1594 (2021)
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Application of Machine Learning to Electroencephalography for the Diagnosis of Primary Progressive Aphasia: A Pilot Study
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In: Brain Sciences ; Volume 11 ; Issue 10 (2021)
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| 20 |
Longitudinal Changes in Cognition, Behaviours, and Functional Abilities in the Three Main Variants of Primary Progressive Aphasia: A Literature Review
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In: Brain Sciences ; Volume 11 ; Issue 9 (2021)
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