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Training-related changes of brain activation for speech production in healthy speakers - a longitudinal fMRI study to mimic aphasia therapy
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Determinants of Concurrent Motor and Language Recovery during Intensive Therapy in Chronic Stroke Patients: Four Single-Case Studies.
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Therapy-induced brain reorganization patterns in aphasia
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In: Brain. - 138, 4 (2015) , 1097-1112, ISSN: 1460-2156 (2015)
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The direction of word stress processing in German: evidence from a working memory paradigm
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Paving the Way for Speech: Voice-Training-Induced Plasticity in Chronic Aphasia and Apraxia of Speech—Three Single Cases
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The neural correlates of agrammatism: Evidence from aphasic and healthy speakers performing an overt picture description task
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Abstract:
Functional brain imaging studies have improved our knowledge of the neural localization of language functions and the functional reorganization after a lesion. However, the neural correlates of agrammatic symptoms in aphasia remain largely unknown. The present fMRI study examined the neural correlates of morpho-syntactic encoding and agrammatic errors in continuous language production by combining three approaches. First, the neural mechanisms underlying natural morpho-syntactic processing in a picture description task were analyzed in 15 healthy speakers. Second, agrammatic-like speech behavior was induced in the same group of healthy speakers to study the underlying functional processes by limiting the utterance length. In a third approach, five agrammatic participants performed the picture description task to gain insights in the neural correlates of agrammatism and the functional reorganization of language processing after stroke. In all approaches, utterances were analyzed for syntactic completeness, complexity, and morphology. Event-related data analysis was conducted by defining every clause-like unit (CLU) as an event with its onset-time and duration. Agrammatic and correct CLUs were contrasted. Due to the small sample size as well as heterogeneous lesion sizes and sites with lesion foci in the insula lobe, inferior frontal, superior temporal and inferior parietal areas the activation patterns in the agrammatic speakers were analyzed on a single subject level. In the group of healthy speakers, posterior temporal and inferior parietal areas were associated with greater morpho-syntactic demands in complete and complex CLUs. The intentional manipulation of morpho-syntactic structures and the omission of function words were associated with additional inferior frontal activation. Overall, the results revealed that the investigation of the neural correlates of agrammatic language production can be reasonably conducted with an overt language production paradigm.
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Keyword:
Psychology
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968764 http://www.ncbi.nlm.nih.gov/pubmed/24711802 https://doi.org/10.3389/fpsyg.2014.00246
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The Role of Human Parietal Area 7A as a Link between Sequencing in Hand Actions and in Overt Speech Production ...
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Enhancement and suppression in a lexical interference fMRI-paradigm ...
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The Role of Human Parietal Area 7A as a Link between Sequencing in Hand Actions and in Overt Speech Production
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Enhancement and suppression in a lexical interference fMRI-paradigm
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Enhancement and suppression in a lexical interference fMRI-paradigm: Mechanisms of Lexical Interference
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In: Brain and Behavior. - 2, 2 (2012) , 109-127, ISSN: 2162-3279 (2012)
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Task-dependent Modulations of Prefrontal and Hippocampal Activity during Intrinsic Word Production
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The separation of processing stages in a lexical interference fMRI-paradigm
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In: NeuroImage. - 44, 3 (2009) , 1113-1124, ISSN: 1053-8119 (2008)
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Deep dysphasia as a phonetic input deficit: Evidence from a single case
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In: Aphasiology. - 22, 5 (2008) , 537-556, ISSN: 0268-7038 (2008)
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Supervised Home Training in Aphasia: Application of the Electronic Language Trainer B.A.Bar - A Single Case Study.
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Measuring change in spontaneous speech production during the course of aphasia: Computer-assisted analysis of basic parameters
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Recovery of semantic word processing in global aphasia: a functional MRI study
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In: Cognitive Brain Research. - 18, 3 (2004) , 322-336, ISSN: 0926-6410 (2004)
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Lexical decision of nonwords and pseudowords in humans: a positron emission tomography study
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In: Neuroscience Letters. - 345, 3 (2003) , 177-181, ISSN: 0304-3940 (2003)
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