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1
Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: the RELEASE database of aphasia after stroke
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2
Dosage, Intensity, and Frequency of Language Therapy for Aphasia: A Systematic Review-Based, Individual Participant Data Network Meta-Analysis
Leemann, B.; Nilipour, R.; Rose, M. L.. - : Lippincott, Williams & Wilkins, 2021
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3
Predictors of Poststroke Aphasia Recovery
Abstract: Background and Purpose: The factors associated with recovery of language domains after stroke remain uncertain. We described recovery of overall-language-ability, auditory comprehension, naming, and functional-communication across participants’ age, sex, and aphasia chronicity in a large, multilingual, international aphasia dataset. Methods: Individual participant data meta-analysis of systematically sourced aphasia datasets described overall-language ability using the Western Aphasia Battery Aphasia-Quotient; auditory comprehension by Aachen Aphasia Test (AAT) Token Test; naming by Boston Naming Test and functional-communication by AAT Spontaneous-Speech Communication subscale. Multivariable analyses regressed absolute score-changes from baseline across language domains onto covariates identified a priori in randomized controlled trials and all study types. Change-from-baseline scores were presented as estimates of means and 95% CIs. Heterogeneity was described using relative variance. Risk of bias was considered at dataset and meta-analysis level. Results: Assessments at baseline (median=43.6 weeks poststroke; interquartile range [4–165.1]) and first-follow-up (median=10 weeks from baseline; interquartile range [3–26]) were available for n=943 on overall-language ability, n=1056 on auditory comprehension, n=791 on naming and n=974 on functional-communication. Younger age (<55 years, +15.4 Western Aphasia Battery Aphasia-Quotient points [CI, 10.0–20.9], +6.1 correct on AAT Token Test [CI, 3.2–8.9]; +9.3 Boston Naming Test points [CI, 4.7–13.9]; +0.8 AAT Spontaneous-Speech Communication subscale points [CI, 0.5–1.0]) and enrollment <1 month post-onset (+19.1 Western Aphasia Battery Aphasia-Quotient points [CI, 13.9–24.4]; +5.3 correct on AAT Token Test [CI, 1.7–8.8]; +11.1 Boston Naming Test points [CI, 5.7–16.5]; and +1.1 AAT Spontaneous-Speech Communication subscale point [CI, 0.7–1.4]) conferred the greatest absolute change-from-baseline across each language domain. Improvements in language scores from baseline diminished with increasing age and aphasia chronicity. Data exhibited no significant statistical heterogeneity. Risk-of-bias was low to moderate-low. Conclusions: Earlier intervention for poststroke aphasia as crucial to maximize language recovery across a range of language domains, although recovery continued to be observed to a lesser extent beyond 6 months poststroke.
Keyword: P Philology. Linguistics; RC Internal medicine
URL: https://openaccess.city.ac.uk/id/eprint/25805/
https://openaccess.city.ac.uk/id/eprint/25805/17/str_stroke-2020-031162_supp1.pdf
https://doi.org/10.1161/strokeaha.120.031162
https://openaccess.city.ac.uk/id/eprint/25805/1/RELEASE%20Predictors%20of%20Aphasia%20Recovery%20Stroke%202021.pdf
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4
Communicating simply, but not too simply: Reporting of participants and speech and language interventions for aphasia after stroke
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5
RELEASE: A protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia
Brady, M. C.; Ali, M.; VandenBerg, K.. - : Taylor & Francis (Routledge), 2019
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6
Tidier descriptions of speech and language therapy interventions for people with aphasia; consensus from the release collaboration
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7
Tidier descriptions of speech and language therapy interventions for people with aphasia; consensus from the RELEASE collaboration
Rose, M.L.; Ali, M.; Elders, A.. - : Taylor & Francis, 2018
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