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Genetic Covariation Underlying Reading, Language and Related Measures in a Sample Selected for Specific Language Impairment
Abstract: Specific language impairment is a developmental language disorder characterized by failure to develop language normally in the absence of a specific cause. Previous twin studies have documented the heritability of reading and language measures as well as the genetic correlation between those measures. This paper presents results from an alternative to the classical twin designs by estimating heritability from extended pedigrees. These pedigrees were previously studied as part of series of molecular genetic studies of specific language impairment where the strongest genetic findings were with reading phenotypes rather than language despite selecting pedigrees based on language impairments. To explore the relationship between reading and language in these pedigrees, variance components estimates of heritability of reading and language measures were conducted showing general agreement with the twin literature, as were genetics correlations between reading and language. Phonological short-term memory, phonological awareness and auditory processing were evaluated as candidate mediators of the reading-language genetic correlations. Only phonological awareness showed significant genetic correlations with all reading measures and several language measures while phonological short-term memory and auditory processing did not.
Keyword: Article
URL: http://www.ncbi.nlm.nih.gov/pubmed/21193955
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129390
https://doi.org/10.1007/s10519-010-9435-0
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2
Specific language impairment in families: evidence for co-occurrence with reading impairments
In: Journal of speech, language, and hearing research. - Rockville, Md. : American Speech-Language-Hearing Association 46 (2003) 3, 530-543
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OLC Linguistik
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3
Language - Articles and Reports - Familial Aggregation in Specific Language Impairment
In: Journal of speech, language, and hearing research. - Rockville, Md. : American Speech-Language-Hearing Association 44 (2001) 5, 1172
OLC Linguistik
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4
Familial aggregation in specific language impairment
In: Journal of speech, language, and hearing research. - Rockville, Md. : American Speech-Language-Hearing Association 44 (2001) 5, 1172-1182
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