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170101 Biological Psychology Neuropsychology, Psychopharmacology, Physiological Psychology (2)
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Chen, Cheng-Yi (2)
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Yawei Cheng (2)
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Hits 1 – 2 of 2
1
An integrative analysis of 5-HTT- mediated mechanism of hyperreactivity to non-threatening voices ...
Chen, Cheng-Yi
;
Róger M. Martínez
;
Tsai-Tsen Liao
. - : figshare, 2020
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2
An integrative analysis of 5-HTT- mediated mechanism of hyperreactivity to non-threatening voices ...
Chen, Cheng-Yi
;
Róger M. Martínez
;
Tsai-Tsen Liao
;
Chih-Yung Yang
;
Chin-Yau Chen
;
Yawei Cheng
. - : figshare, 2020
Abstract:
The tonic model delineating the serotonin transporter polymorphism’s (5-HTTLPR) 5-HTT-dependent neural modulatory effect on anxietyion points towards a universal underlying mechanism involving a hyper-or-elevated baseline level of arousal even to non-threatening stimuli. However, to our knowledge, this mechanism has never been proven observed in non-clinical cohorts exhibiting high anxiety. Moreover, empirical support regarding said association is mixed, potentially because of publication bias with a relatively small sample size. Hence, how the 5-HTTLPR modulates neural correlates remains controversial. Here we show, we assessed state and trait anxiety in 334 healthy volunteers, and subsequently genotyped the 5-HTTLPR and recorded the mismatch negativity (MMN) elicited by the unexpected presence of emotional prosodies embedded among neutrally-spoken syllables within a passive auditory oddball paradigm (emotional MMN) in 188 of them. Results revealed that 5-HTTLPR short-allele carriers had significantly ...
Keyword:
170101 Biological Psychology Neuropsychology, Psychopharmacology, Physiological Psychology
;
FOS Psychology
;
Neuroscience
URL:
https://dx.doi.org/10.6084/m9.figshare.11815875.v1
https://figshare.com/articles/An_integrative_analysis_of_5-HTT-_mediated_mechanism_of_hyperreactivity_to_non-threatening_voices/11815875/1
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