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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 11 of 11 1 Tractography of supplementary motor area projections in progressive speech apraxia and aphasia Valls Carbo, Adrian; Reid, Robert I.; Tosakulwong, Nirubol... In: Neuroimage Clin (2022) BASE Show details 2 A molecular pathology, neurobiology, biochemical, genetic and neuroimaging study of progressive apraxia of speech Josephs, Keith A.; Duffy, Joseph R.; Clark, Heather M.... In: Nat Commun (2021) BASE Show details 3 Clinical and Neuroimaging Characteristics of Clinically Unclassifiable Primary Progressive Aphasia Utianski, Rene L.; Botha, Hugo; Martin, Peter R.... In: Brain Lang (2019) BASE Show details 4 The influence of β-amyloid on [(18)F]AV-1451 in semantic variant of primary progressive aphasia Whitwell, Jennifer L.; Martin, Peter R.; Duffy, Joseph R.. - : Lippincott Williams & Wilkins, 2019 BASE Show details 5 [18F]AV-1451 tau-PET and primary progressive aphasia Josephs, Keith A.; Martin, Peter R.; Botha, Hugo. - 2018 BASE Show details 6 Tau Uptake in Agrammatic Primary Progressive Aphasia with and without Apraxia of Speech Utianski, Rene L.; Whitwell, Jennifer L.; Schwarz, Christopher G.; Duffy, Joseph R.; Botha, Hugo; Clark, Heather M.; Machulda, Mary M.; Senjem, Matthew L.; Knopman, David S.; Petersen, Ronald C.; Jack, Clifford R.; Lowe, Val J.; Josephs, Keith A.. - 2018 Abstract: BACKGROUND: The nonfluent/agrammatic variant of primary progressive aphasia (agPPA) is a heterogeneous diagnosis, wherein some individuals have apraxia of speech (AOS). When agPPA includes AOS, a tauopathy is likely the underlying pathology. Recently, [18F]AV-1451 was developed for the in vivo assessment of tau. In this study, we compare patterns of tau tracer uptake in agPPA patients, with and without apraxia of speech. METHODS: Nine agPPA patients (four without AOS) underwent tau-PET imaging with [18F]AV-1451. Uptake of [18F]AV-1451 was assessed as cortical to cerebellar crus ratios (SUVr) in cortical regions of interest measured using the MCALT atlas and compared voxel-wise in SPM12. Each patient was age- and sex-matched to three controls. RESULTS: agPPA without AOS showed uptake in the left frontal and temporal lobes, while agPPA with AOS showed uptake in the bilateral supplementary motor areas, frontal lobes, precuneus, and precentral gyrus, relative to controls. The left precentral gyrus had uptake in agPPA with AOS, relative to those without AOS. CONCLUSIONS: This cross-sectional study suggests [18F]AV-1451 uptake in the precentral gyrus is implicated in AOS in agPPA. Keyword: Article URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181763/ http://www.ncbi.nlm.nih.gov/pubmed/29935044 https://doi.org/10.1111/ene.13733 BASE Hide details 7 Disrupted functional connectivity in primary progressive apraxia of speech Botha, Hugo; Utianski, Rene L.; Whitwell, Jennifer L.. - : Elsevier, 2018 BASE Show details 8 Tau-PET imaging with [18F]AV-1451 in Primary Progressive Apraxia of Speech Utianski, Rene L.; Whitwell, Jennifer L.; Schwarz, Christopher G.. - 2018 BASE Show details 9 Prosodic and Phonetic Subtypes of Primary Progressive Apraxia of Speech Utianski, Rene L.; Duffy, Joseph R.; Clark, Heather M.. - 2018 BASE Show details 10 Predicting clinical decline in progressive agrammatic aphasia and apraxia of speech Whitwell, Jennifer L.; Weigand, Stephen D.; Duffy, Joseph R.. - : Lippincott Williams & Wilkins, 2017 BASE Show details 11 Tracking the Development of Agrammatic Aphasia: a Tensor-Based Morphometry Study Whitwell, Jennifer L.; Duffy, Joseph R.; Machulda, Mary M.. - 2016 BASE Show details

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