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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 13 of 13 1 Attentional abilities constrain language development: A cross-syndrome infant/toddler study D'Souza, Dean; D'Souza, Hana; Jones, Emily. - : Wiley, 2020 BASE Show details 2 Sleep is atypical across neurodevelopmental disorders in infants and toddlers: A cross-syndrome study Karmiloff-Smith, Annette; Plunkett, Kim; Horváth, Klára. - : Elsevier, 2020 BASE Show details 3 Down syndrome and parental depression: a double hit on early expressive language development D'Souza, Hana; Lathan, A.; Karmiloff Smith, Annette. - : Elsevier, 2020 BASE Show details 4 Attentional abilities constrain language development: a cross-syndrome infant/toddler study D'souza, Dean; D'Souza, Hana; Jones, Emily J.H.. - : Wiley, 2020 BASE Show details 5 Health comorbidities and cognitive abilities across the lifespan in Down syndrome. ... Startin, Carla M; D'Souza, Hana; Ball, George. - : Apollo - University of Cambridge Repository, 2020 BASE Show details 6 A multi-level developmental approach to exploring individual differences in Down syndrome: genes, brain, behaviour, and environment. ... Thomas, Michael SC; Ojinaga Alfageme, Olatz; D'Souza, Hana. - : Apollo - University of Cambridge Repository, 2020 BASE Show details 7 Down syndrome and parental depression: A double hit on early expressive language development. ... D'Souza, Hana; Lathan, Amanda; Karmiloff-Smith, Annette. - : Apollo - University of Cambridge Repository, 2020 BASE Show details 8 Down syndrome and parental depression: A double hit on early expressive language development. D'Souza, Hana; Lathan, Amanda; Karmiloff-Smith, Annette. - : Elsevier BV, 2020. : Res Dev Disabil, 2020 BASE Show details 9 A multi-level developmental approach to exploring individual differences in Down syndrome: genes, brain, behaviour, and environment. Thomas, Michael SC; Ojinaga Alfageme, Olatz; D'Souza, Hana. - : Research in developmental disabilities, 2020 BASE Show details 10 Health comorbidities and cognitive abilities across the lifespan in Down syndrome. Startin, Carla M; D'Souza, Hana; Ball, George; Hamburg, Sarah; Hithersay, Rosalyn; Hughes, Kate MO; Massand, Esha; Karmiloff-Smith, Annette; Thomas, Michael SC; LonDownS Consortium; Strydom, Andre. - : Springer Science and Business Media LLC, 2020. : J Neurodev Disord, 2020 Abstract: BACKGROUND: Down syndrome (DS) is associated with variable intellectual disability and multiple health and psychiatric comorbidities. The impact of such comorbidities on cognitive outcomes is unknown. We aimed to describe patterns of physical health and psychiatric comorbidity prevalence, and receptive language ability, in DS across the lifespan, and determine relationships with cognitive outcomes. METHODS: Detailed medical histories were collected and cognitive abilities measured using standardised tests for 602 individuals with DS from England and Wales (age range 3 months to 73 years). Differences in prevalence rates between age groups and between males and females were determined using chi-squared or Fisher's exact tests. In adults, rates for psychiatric comorbidities were compared to expected population rates using standardised morbidity ratios (SMRs). Adapted ANCOVA functions were constructed to explore age and sex associations with receptive language ability across the lifespan, and regression analyses were performed to determine whether the presence of health comorbidities or physical phenotypes predicted cognitive abilities. RESULTS: Multiple comorbidities showed prevalence differences across the lifespan, though there were few sex differences. In adults, SMRs were increased in males and decreased in females with DS for schizophrenia, bipolar disorder, and anxiety. Further, SMRs were increased in both males and females with DS for dementia, autism, ADHD, and depression, with differences more pronounced in females for dementia and autism, and in males for depression. Across the lifespan, receptive language abilities increasingly deviated from age-typical levels, and males scored poorer than females. Only autism and epilepsy were associated with poorer cognitive ability in those aged 16-35 years, with no relationships for physical health comorbidities, including congenital heart defects. CONCLUSIONS: Our results indicate the prevalence of multiple comorbidities varies across the lifespan in DS, and in adults, rates for psychiatric comorbidities show different patterns for males and females relative to expected population rates. Further, most health comorbidities are not associated with poorer cognitive outcomes in DS, apart from autism and epilepsy. It is essential for clinicians to consider such differences to provide appropriate care and treatment for those with DS and to provide prognostic information relating to cognitive outcomes in those with comorbidities. Keyword: 80 and over; Adolescent; Adult; Aged; Child; Cognition; Comorbidity; Down Syndrome; Female; Humans; Infant; Language Development Disorders; LonDownS Consortium; Longevity; Male; Mental Disorders; Middle Aged; Preschool; Sex Characteristics; United Kingdom; Young Adult URL: https://doi.org/10.17863/CAM.58181 https://www.repository.cam.ac.uk/handle/1810/311092 BASE Hide details 11 Precursors to language development in typically and atypically developing infants and toddlers: the importance of embracing complexity D'Souza, Hana; D'Souza, Dean; Karmiloff-Smith, Annette. - : Cambridge Journals, 2017 BASE Show details 12 Audio-visual speech perception in infants and toddlers with Down syndrome, fragile X syndrome, and Williams syndrome Karmiloff-Smith, Annette; D'Souza, Hana; Johnson, Mark H.. - : Elsevier, 2016 BASE Show details 13 Concurrent Relations between Face Scanning and Language: A Cross-Syndrome Infant Study. ... D'Souza, Dean; D'Souza, Hana; Johnson, Mark. - : Apollo - University of Cambridge Repository, 2015 BASE Show details

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