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1
Cortical microstructure in primary progressive aphasia: a multicenter study.
In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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2
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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3
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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4
Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease.
Chapleau, Marianne; Bedetti, Christophe; Devenyi, Gabriel A. - : eScholarship, University of California, 2020
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5
Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.
Lee, Suzee E; Sias, Ana C; Kosik, Eena L. - : eScholarship, University of California, 2019
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6
Factors that predict diagnostic stability in neurodegenerative dementia.
In: Journal of neurology, vol 266, iss 8 (2019)
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7
Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.
Lee, Suzee E; Sias, Ana C; Kosik, Eena L. - : eScholarship, University of California, 2019
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8
Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease.
In: Scientific reports, vol 9, iss 1 (2019)
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9
Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease.
In: Scientific reports, vol 9, iss 1 (2019)
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10
Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.
In: JAMA neurology, vol 75, iss 3 (2018)
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11
Emotion detection deficits and changes in personality traits linked to loss of white matter integrity in primary progressive aphasia.
Multani, Namita; Galantucci, Sebastiano; Wilson, Stephen M. - : eScholarship, University of California, 2017
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12
Observing conversational laughter in frontotemporal dementia.
In: Journal of neurology, neurosurgery, and psychiatry, vol 88, iss 5 (2017)
Abstract: BackgroundWe performed an observational study of laughter during seminaturalistic conversations between patients with dementia and familial caregivers. Patients were diagnosed with (1) behavioural variant frontotemporal dementia (bvFTD), (2) right temporal variant frontotemporal dementia (rtFTD), (3) semantic variant of primary progressive aphasia (svPPA), (4) non-fluent variant primary progressive aphasia (nfvPPA) or (5) early onset Alzheimer's disease (eoAD). We hypothesised that those with bvFTD would laugh less in response to their own speech than other dementia groups or controls, while those with rtFTD would laugh less regardless of who was speaking.MethodsPatients with bvFTD (n=39), svPPA (n=19), rtFTD (n=14), nfvPPA (n=16), eoAD (n=17) and healthy controls (n=156) were recorded (video and audio) while discussing a problem in their relationship with a healthy control companion. Using the audio track only, laughs were identified by trained coders and then further classed by an automated algorithm as occurring during or shortly after the participant's own vocalisation ('self' context) or during or shortly after the partner's vocalisation ('partner' context).ResultsIndividuals with bvFTD, eoAD or rtFTD laughed less across both contexts of self and partner than the other groups. Those with bvFTD laughed less relative to their own speech comparedwith healthy controls. Those with nfvPPA laughed more in the partner context compared with healthy controls.ConclusionsLaughter in response to one's own vocalisations or those of a conversational partner may be a clinically useful measure in dementia diagnosis.
Keyword: 2.1 Biological and endogenous factors; Acquired Cognitive Impairment; Aged; Aging; Alzheimer Disease; Alzheimer's Disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Aphasia; Brain; Brain Disorders; Clinical Research; Dementia; Female; Frontotemporal Dementia; Frontotemporal Dementia (FTD); Humans; Laughter; Magnetic Resonance Imaging; Male; Medical and Health Sciences; Middle Aged; Neurodegenerative; Neurological; Neurology & Neurosurgery; Neuropsychological Tests; Neurosciences; Primary Progressive; Primary Progressive Nonfluent Aphasia; Psychology and Cognitive Sciences; Rare Diseases; Speech
URL: https://escholarship.org/uc/item/6r4531sc
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13
Increased prevalence of autoimmune disease within C9 and FTD/MND cohorts: Completing the picture.
In: Neurology(R) neuroimmunology & neuroinflammation, vol 3, iss 6 (2016)
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