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Sparse canonical correlation analysis relates network-level atrophy to multivariate cognitive measures in a neurodegenerative population
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2
Sentence processing in Lewy body spectrum disorder: the role of working memory
In: Brain and cognition. - San Diego, Calif. [u.a.] : Elsevier Science 78 (2012) 2, 85-93
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OLC Linguistik
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SENTENCE PROCESSING IN LEWY BODY SPECTRUM DISORDER: THE ROLE OF WORKING MEMORY
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The Philadelphia Brief Assessment of Cognition (PBAC): A Validated Screening Measure for Dementia
Abstract: The Philadelphia Brief Assessment of the Cognition (PBAC) is a brief dementia-screening instrument. The PBAC assesses five cognitive domains: working memory/executive control; lexical retrieval/language; visuospatial/visuoconstructional operations; verbal/visual episodic memory; and behavior/social comportment. A revised version of the PBAC was administered to 198 participants including patients with Alzheimer’s disease (AD) (n=46) and four groups of patients with frontotemporal dementia (FTD) syndromes: behavioral-variant FTD (bvFTD; n=65), semantic-variant primary progressive aphasia (PPA) (svPPA; n=22), non-fluent/agrammatic-variant PPA (nfaPPA; n=23), and corticobasal syndrome (CBS; n=42), and a group of normal controls (n=15). The total PBAC score was highly correlated with the MMSE. The criterion validity of the PBAC was assessed relative to standard neuropsychological test performance. Using standard neuropsychological test performance as a criterion, the total PBAC score accurately identified the presence and severity of dementia. Intra-class correlations between PBAC subscales and standard neuropsychological tests were highly significant. PBAC subscales demonstrated good clinical utility in distinguishing AD and FTD subtypes using receiver operating characteristic analysis and standard diagnostic performance statistics to determine optimal subscale cut scores. The PBAC is a valid tool and able to assesses differential patterns neuropsychological/behavioral impairment in a broad range of neurodegenerative conditions.
Keyword: Article
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297195
http://www.ncbi.nlm.nih.gov/pubmed/22084867
https://doi.org/10.1080/13854046.2011.631585
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