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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 9 of 9 1 Comparative semantic profiles in semantic dementia and Alzheimer's disease Libon, David J.; Rascovsky, Katya; Powers, John; Irwin, David J.; Boller, Ashley; Weinberg, Danielle; McMillan, Corey T.; Grossman, Murray. - : Oxford University Press, 2013 Abstract: Patients with the semantic variant of primary progressive aphasia, also known as semantic dementia, and Alzheimer’s disease have deficits in semantic memory. However, few comparative studies have been performed to determine whether these patient groups have distinct semantic memory impairments. We asked 15 patients with semantic variant primary progressive aphasia and 57 patients with Alzheimer’s disease to judge semantic category membership of coloured photos and printed words that are members of familiar natural and manufactured categories, and we related performance to grey matter atrophy. We found that both semantic variant primary progressive aphasia and Alzheimer’s disease are significantly impaired on this task. Moreover, patients with semantic variant primary progressive aphasia had a significantly more prominent deficit for natural objects than their own deficit judging manufactured objects. Both semantic variant primary progressive aphasia and Alzheimer’s disease had atrophy that included portions of the left temporal lobe. Regression analyses related performance in semantic variant primary progressive aphasia to ventral and medial portions of the left temporal lobe, while regression analyses in Alzheimer’s disease related performance to these ventral and medial temporal areas as well as lateral temporal-parietal regions in the left hemisphere. We conclude that both semantic variant primary progressive aphasia and Alzheimer’s disease are significantly impaired in a simple category membership judgement task and the selective impairment for natural kinds in semantic variant primary progressive aphasia is related in part to disease in visual association cortex in ventral–medial portions of the left temporal lobe. We discuss factors that may contribute to the semantic memory deficit in semantic variant primary progressive aphasia. Keyword: Original Articles URL: https://doi.org/10.1093/brain/awt165 http://brain.oxfordjournals.org/cgi/content/short/136/8/2497 BASE Hide details 2 Sparse canonical correlation analysis relates network-level atrophy to multivariate cognitive measures in a neurodegenerative population Avants, Brian B.; Libon, David J.; Rascovsky, Katya. - 2013 BASE Show details 3 Comparative semantic profiles in semantic dementia and Alzheimer’s disease Libon, David J.; Rascovsky, Katya; Powers, John. - : Oxford University Press, 2013 BASE Show details 4 Sentence processing in Lewy body spectrum disorder: the role of working memory Moore, Peachie; Grossman, Murray; Siderowf, Andrew... In: Brain and cognition. - San Diego, Calif. [u.a.] : Elsevier Science 78 (2012) 2, 85-93 BLLDB OLC Linguistik Show details 5 SENTENCE PROCESSING IN LEWY BODY SPECTRUM DISORDER: THE ROLE OF WORKING MEMORY Gross, Rachel G.; McMillan, Corey T.; Chandrasekaran, Keerthi. - 2012 BASE Show details 6 The Philadelphia Brief Assessment of Cognition (PBAC): A Validated Screening Measure for Dementia Libon, David J.; Rascovsky, Katya; Gross, Rachel G.. - 2011 BASE Show details 7 The importance of multiple assessments of object knowledge in semantic dementia: The case of the familiar objects task Chrysikou, Evangelia G.; Giovannetti, Tania; Wambach, Denene M.. - 2010 BASE Show details 8 Neuropsychological Decline in Frontotemporal Lobar Degeneration: A Longitudinal Analysis Libon, David J.; Xie, Sharon X.; Wang, Xingmei. - 2009 BASE Show details 9 Longitudinal Patterns of Semantic and Episodic Memory in Frontotemporal Lobar Degeneration and Alzheimer’s Disease Xie, Sharon X.; Libon, David J.; Wang, Xingmei. - 2009 BASE Show details

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