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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Page: 1 2 Hits 1 – 20 of 39 1 Health comorbidities and cognitive abilities across the lifespan in Down syndrome. ... Startin, Carla M; D'Souza, Hana; Ball, George. - : Apollo - University of Cambridge Repository, 2020 BASE Show details 2 A multi-level developmental approach to exploring individual differences in Down syndrome: genes, brain, behaviour, and environment. ... Thomas, Michael SC; Ojinaga Alfageme, Olatz; D'Souza, Hana. - : Apollo - University of Cambridge Repository, 2020 BASE Show details 3 Down syndrome and parental depression: A double hit on early expressive language development. ... D'Souza, Hana; Lathan, Amanda; Karmiloff-Smith, Annette. - : Apollo - University of Cambridge Repository, 2020 BASE Show details 4 Down syndrome and parental depression: A double hit on early expressive language development. D'Souza, Hana; Lathan, Amanda; Karmiloff-Smith, Annette. - : Elsevier BV, 2020. : Res Dev Disabil, 2020 BASE Show details 5 A multi-level developmental approach to exploring individual differences in Down syndrome: genes, brain, behaviour, and environment. Thomas, Michael SC; Ojinaga Alfageme, Olatz; D'Souza, Hana. - : Research in developmental disabilities, 2020 BASE Show details 6 Health comorbidities and cognitive abilities across the lifespan in Down syndrome. Startin, Carla M; D'Souza, Hana; Ball, George; Hamburg, Sarah; Hithersay, Rosalyn; Hughes, Kate MO; Massand, Esha; Karmiloff-Smith, Annette; Thomas, Michael SC; LonDownS Consortium; Strydom, Andre. - : Springer Science and Business Media LLC, 2020. : J Neurodev Disord, 2020 Abstract: BACKGROUND: Down syndrome (DS) is associated with variable intellectual disability and multiple health and psychiatric comorbidities. The impact of such comorbidities on cognitive outcomes is unknown. We aimed to describe patterns of physical health and psychiatric comorbidity prevalence, and receptive language ability, in DS across the lifespan, and determine relationships with cognitive outcomes. METHODS: Detailed medical histories were collected and cognitive abilities measured using standardised tests for 602 individuals with DS from England and Wales (age range 3 months to 73 years). Differences in prevalence rates between age groups and between males and females were determined using chi-squared or Fisher's exact tests. In adults, rates for psychiatric comorbidities were compared to expected population rates using standardised morbidity ratios (SMRs). Adapted ANCOVA functions were constructed to explore age and sex associations with receptive language ability across the lifespan, and regression analyses were performed to determine whether the presence of health comorbidities or physical phenotypes predicted cognitive abilities. RESULTS: Multiple comorbidities showed prevalence differences across the lifespan, though there were few sex differences. In adults, SMRs were increased in males and decreased in females with DS for schizophrenia, bipolar disorder, and anxiety. Further, SMRs were increased in both males and females with DS for dementia, autism, ADHD, and depression, with differences more pronounced in females for dementia and autism, and in males for depression. Across the lifespan, receptive language abilities increasingly deviated from age-typical levels, and males scored poorer than females. Only autism and epilepsy were associated with poorer cognitive ability in those aged 16-35 years, with no relationships for physical health comorbidities, including congenital heart defects. CONCLUSIONS: Our results indicate the prevalence of multiple comorbidities varies across the lifespan in DS, and in adults, rates for psychiatric comorbidities show different patterns for males and females relative to expected population rates. Further, most health comorbidities are not associated with poorer cognitive outcomes in DS, apart from autism and epilepsy. It is essential for clinicians to consider such differences to provide appropriate care and treatment for those with DS and to provide prognostic information relating to cognitive outcomes in those with comorbidities. Keyword: 80 and over; Adolescent; Adult; Aged; Child; Cognition; Comorbidity; Down Syndrome; Female; Humans; Infant; Language Development Disorders; LonDownS Consortium; Longevity; Male; Mental Disorders; Middle Aged; Preschool; Sex Characteristics; United Kingdom; Young Adult URL: https://doi.org/10.17863/CAM.58181 https://www.repository.cam.ac.uk/handle/1810/311092 BASE Hide details 7 Concurrent Relations between Face Scanning and Language: A Cross-Syndrome Infant Study. ... D'Souza, Dean; D'Souza, Hana; Johnson, Mark. - : Apollo - University of Cambridge Repository, 2015 BASE Show details 8 When modularization fails to occur: a developmental perspective D'Souza, Dean; Karmiloff-Smith, Annette In: Cognitive neuropsychology. - Abingdon : Routledge, Taylor & Francis Group 28 (2011) 3-4, 276-287 BLLDB OLC Linguistik Show details 9 Long-term effects of preterm birth on language and literacy at eight years Faldella, Giacomo; Savini, Silvia; Guarini, Annalisa... In: Journal of child language. - Cambridge [u.a.] : Cambridge Univ. Press 37 (2010) 4, 865-885 BLLDB OLC Linguistik Show details 10 Using developmental trajectories to understand developmental disorders Ansari, Daniel; Karmiloff-Smith, Annette; Jarrold, Christopher... In: Journal of speech, language, and hearing research. - Rockville, Md. : American Speech-Language-Hearing Association 52 (2009) 2, 336-358 BLLDB OLC Linguistik Show details 11 Preaching to the converted? From constructivism to neuroconstructivism : [comment] Karmiloff-Smith, Annette In: Child development perspectives. - Hoboken, NJ : Wiley 3 (2009) 2, 99-102 BLLDB Show details 12 Nativism versus neuroconstructivism: rethinking the study of developmental disorders Karmiloff-Smith, Annette In: Developmental psychology. - Richmond, Va. [u.a.] : American Psychological Association 45 (2009) 1, 56-63 BLLDB Show details 13 From numerical concepts to concepts of number : [including open peer commentary and authors' response] Halberda, Justin (Komm.); Lourenco, Stella F. (Komm.); Smith, Leslie (Komm.)... In: Behavioral and brain sciences. - New York, NY [u.a.] : Cambridge Univ. Press 31 (2008) 6, 623-687 BLLDB OLC Linguistik Show details 14 Language and life history: a new perspective on the development and evolution of human language : [including open peer commentary and authors' response] Johansson, Sverker (Komm.); Gogate, Lakshmi J. (Komm.); Powers, David M. W. (Komm.)... In: Behavioral and brain sciences. - New York, NY [u.a.] : Cambridge Univ. Press 29 (2006) 3, 259-325 BLLDB OLC Linguistik Show details 15 Asynchrony in the cognitive and lexical development of young children with Williams syndrome Nazzi, Thierry; Gopnik, Alison; Karmiloff-Smith, Annette In: Journal of child language. - Cambridge [u.a.] : Cambridge Univ. Press 32 (2005) 2, 427-438 BLLDB Show details 16 Can developmental disorders reveal the component parts of the human language faculty? Thomas, Michael S. C.; Karmiloff-Smith, Annette In: Language learning and development. - Philadelphia, Pa. : Taylor & Francis 1 (2005) 1, 65-92 BLLDB Show details 17 Modeling language acquisition in atypical phenotypes Thomas, Michael S. C.; Karmiloff-Smith, Annette In: Psychological review. - Washington, DC [u.a.] : American Psychological Association 110 (2003) 4, 647-682 BLLDB Show details 18 What makes counting count? : Verbal and visuo-spatial contributions to typical and atypical number development Ansari, Daniel; Donlan, Christopher; Thomas, Michael S. C.... In: Journal of experimental child psychology. - Orlando, Fla. : Acad. Press 85 (2003) 1, 50-62 BLLDB Show details 19 Representation, memory, and development : essays in honor of Jean Mandler Hespos, Susan J. (Mitarb.); Spelke, Elizabeth S. (Mitarb.); Leslie, Alan M. (Mitarb.). - Mahwah, NJ : Erlbaum, 2002 BLLDB UB Frankfurt Linguistik Show details 20 Are developmental disorders like cases of adult brain damage? : Implications from connectionist modelling (incl. open peer commentary and authors' response) Thomas, Michael S. C.; Karmiloff-Smith, Annette; Briscoe, J. (Mitarb.)... In: Behavioral and brain sciences. - New York, NY [u.a.] : Cambridge Univ. Press 25 (2002) 6, 727-787 BLLDB Show details Page: 1 2

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