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1
Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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3
Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium
In: Alzheimers Dement (2020)
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4
Longitudinal structural and metabolic changes in frontotemporal dementia
In: Neurology (2020)
Abstract: OBJECTIVE: To compare the sensitivity of structural MRI and (18)F-fludeoxyglucose PET ((18)FDG-PET) to detect longitudinal changes in frontotemporal dementia (FTD). METHODS: Thirty patients with behavioral variant FTD (bvFTD), 7 with nonfluent/agrammatic variant primary progressive aphasia (nfvPPA), 16 with semantic variant primary progressive aphasia (svPPA), and 43 cognitively normal controls underwent 2–4 MRI and (18)FDG-PET scans (total scans/visit = 270) as part of the Frontotemporal Lobar Degeneration Neuroimaging Initiative study. Linear mixed-effects models were carried out voxel-wise and in regions of interest to identify areas showing decreased volume or metabolism over time in patients as compared to controls. RESULTS: At baseline, patients with bvFTD showed bilateral temporal, dorsolateral, and medial prefrontal atrophy/hypometabolism that extended with time into adjacent structures and parietal lobe. In nfvPPA, baseline atrophy/hypometabolism in supplementary motor cortex extended with time into left greater than right precentral, dorsolateral, and dorsomedial prefrontal cortex. In svPPA, baseline atrophy/hypometabolism encompassed the anterior temporal and medial prefrontal cortex and longitudinal changes were found in temporal, orbitofrontal, and lateral parietal cortex. Across syndromes, there was substantial overlap in the brain regions showing volume and metabolism loss. Even though the pattern of metabolic decline was more extensive, metabolic changes were also more variable and sample size estimates were similar or higher for (18)FDG-PET compared to MRI. CONCLUSION: Our findings demonstrated the sensitivity of (18)FDG-PET and structural MRI for tracking disease progression in FTD. Both modalities showed highly overlapping patterns of longitudinal change and comparable sample size estimates to detect longitudinal changes in future clinical trials.
Keyword: Article
URL: https://doi.org/10.1212/WNL.0000000000009760
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455324/
http://www.ncbi.nlm.nih.gov/pubmed/32591470
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5
Data from: Longitudinal structural and metabolic changes in frontotemporal dementia ...
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6
Patient-Tailored, Connectivity-Based Forecasts of Spreading Brain Atrophy
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7
Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory.
In: Annals of clinical and translational neurology, vol 5, iss 10 (2018)
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8
Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory.
In: Annals of clinical and translational neurology, vol 5, iss 10 (2018)
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9
Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease.
Elahi, Fanny M; Marx, Gabe; Cobigo, Yann. - : eScholarship, University of California, 2017
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10
Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease.
Elahi, Fanny M; Marx, Gabe; Cobigo, Yann. - : eScholarship, University of California, 2017
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11
Data-driven regions of interest for longitudinal change in three variants of frontotemporal lobar degeneration.
In: Brain and behavior, vol 7, iss 4 (2017)
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12
Data-driven regions of interest for longitudinal change in three variants of frontotemporal lobar degeneration.
In: Brain and behavior, vol 7, iss 4 (2017)
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13
Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional–executive network function in Alzheimer’s disease
Wolk, David A.; Dickerson, Bradford C.; Weiner, Michael. - : National Academy of Sciences, 2010
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