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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 18 of 18 1 A molecular pathology, neurobiology, biochemical, genetic and neuroimaging study of progressive apraxia of speech Josephs, Keith A.; Duffy, Joseph R.; Clark, Heather M.; Utianski, Rene L.; Strand, Edythe A.; Machulda, Mary M.; Botha, Hugo; Martin, Peter R.; Pham, Nha Trang Thu; Stierwalt, Julie; Ali, Farwa; Buciuc, Marina; Baker, Matthew; Fernandez De Castro, Cristhoper H.; Spychalla, Anthony J.; Schwarz, Christopher G.; Reid, Robert I.; Senjem, Matthew L.; Jack, Clifford R.; Lowe, Val J.; Bigio, Eileen H.; Reichard, Ross R.; Polley, Eric. J.; Ertekin-Taner, Nilufer; Rademakers, Rosa; DeTure, Michael A.; Ross, Owen A.; Dickson, Dennis W.; Whitwell, Jennifer L. In: Nat Commun (2021) Abstract: Progressive apraxia of speech is a neurodegenerative syndrome affecting spoken communication. Molecular pathology, biochemistry, genetics, and longitudinal imaging were investigated in 32 autopsy-confirmed patients with progressive apraxia of speech who were followed over 10 years. Corticobasal degeneration and progressive supranuclear palsy (4R-tauopathies) were the most common underlying pathologies. Perceptually distinct speech characteristics, combined with age-at-onset, predicted specific 4R-tauopathy; phonetic subtype and younger age predicted corticobasal degeneration, and prosodic subtype and older age predicted progressive supranuclear palsy. Phonetic and prosodic subtypes showed differing relationships within the cortico-striato-pallido-nigro-luysial network. Biochemical analysis revealed no distinct differences in aggregated 4R-tau while tau H1 haplotype frequency (69%) was lower compared to 1000+ autopsy-confirmed 4R-tauopathies. Corticobasal degeneration patients had faster rates of decline, greater cortical degeneration, and shorter illness duration than progressive supranuclear palsy. These findings help define the pathobiology of progressive apraxia of speech and may have consequences for development of 4R-tau targeting treatment. Keyword: Article URL: http://www.ncbi.nlm.nih.gov/pubmed/34103532 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187627/ https://doi.org/10.1038/s41467-021-23687-8 BASE Hide details 2 Longitudinal anatomic, functional, and molecular characterization of Pick disease phenotypes Whitwell, Jennifer L.; Tosakulwong, Nirubol; Schwarz, Christopher C.... In: Neurology (2020) BASE Show details 3 Clinical and Neuroimaging Characteristics of Clinically Unclassifiable Primary Progressive Aphasia Utianski, Rene L.; Botha, Hugo; Martin, Peter R.... In: Brain Lang (2019) BASE Show details 4 The influence of β-amyloid on [(18)F]AV-1451 in semantic variant of primary progressive aphasia Whitwell, Jennifer L.; Martin, Peter R.; Duffy, Joseph R.. - : Lippincott Williams & Wilkins, 2019 BASE Show details 5 Patterns of Neuropsychological Dysfunction and Cortical Volume Changes in Logopenic Aphasia Owens, Tyler E.; Machulda, Mary M.; Duffy, Joseph R.. - 2018 BASE Show details 6 [18F]AV-1451 tau-PET and primary progressive aphasia Josephs, Keith A.; Martin, Peter R.; Botha, Hugo. - 2018 BASE Show details 7 Tau Uptake in Agrammatic Primary Progressive Aphasia with and without Apraxia of Speech Utianski, Rene L.; Whitwell, Jennifer L.; Schwarz, Christopher G.. - 2018 BASE Show details 8 Tau-PET imaging with [18F]AV-1451 in Primary Progressive Apraxia of Speech Utianski, Rene L.; Whitwell, Jennifer L.; Schwarz, Christopher G.. - 2018 BASE Show details 9 Prosodic and Phonetic Subtypes of Primary Progressive Apraxia of Speech Utianski, Rene L.; Duffy, Joseph R.; Clark, Heather M.. - 2018 BASE Show details 10 Varying degrees of temporoparietal hypometabolism on FDG-PET reveal amyloid-positive logopenic primary progressive aphasia is not a homogeneous clinical entity Krishnan, Kamini; Machulda, Mary M.; Whitwell, Jennifer L.. - 2017 BASE Show details 11 Clinical and MRI models predicting amyloid deposition in progressive aphasia and apraxia of speech Whitwell, Jennifer L.; Weigand, Stephen D.; Duffy, Joseph R.. - : Elsevier, 2016 BASE Show details 12 Clinical and neuroimaging biomarkers of amyloid-negative logopenic primary progressive aphasia Whitwell, Jennifer L.; Duffy, Joseph R.; Strand, Edythe A.. - 2015 BASE Show details 13 Regional β-amyloid burden does not correlate with cognitive or language deficits in Alzheimer’s disease presenting as aphasia Jung, Youngsin; Whitwell, Jennifer L.; Duffy, Joseph R.. - 2015 BASE Show details 14 APOE4 influences β-amyloid burden in primary progressive aphasia and speech apraxia Josephs, Keith A.; Duffy, Joseph R.; Strand, Edythe A.. - 2014 BASE Show details 15 Elevated occipital β-amyloid deposition is associated with widespread cognitive impairment in logopenic progressive aphasia Whitwell, Jennifer L.; Lowe, Val J.; Duffy, Joseph R.. - 2013 BASE Show details 16 FDG PET and MRI in Logopenic Primary Progressive Aphasia versus Dementia of the Alzheimer’s Type Madhavan, Ajay; Whitwell, Jennifer L.; Weigand, Stephen D.. - : Public Library of Science, 2013 BASE Show details 17 Microbleeds in the logopenic variant of primary progressive aphasia Whitwell, Jennifer L.; Jack, Clifford R.; Duffy, Joseph R.. - 2013 BASE Show details 18 Distinct regional anatomic and functional correlates of neurodegenerative apraxia of speech and aphasia: an MRI and FDG-PET study Whitwell, Jennifer L.; Duffy, Joseph R.; Strand, Edythe A.. - 2013 BASE Show details

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