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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Page: 1 2 3 Hits 1 – 20 of 46 1 Cortical microstructure in primary progressive aphasia: a multicenter study. Illán-Gala, Ignacio; Montal, Victor; Borrego-Écija, Sergi; Mandelli, Maria Luisa; Falgàs, Neus; Welch, Ariane E; Pegueroles, Jordi; Santos-Santos, Miguel; Bejanin, Alexandre; Alcolea, Daniel; Dols-Icardo, Oriol; Belbin, Olivia; Sánchez-Saudinós, Mª Belén; Bargalló, Nuria; González-Ortiz, Sofía; Lladó, Albert; Blesa, Rafael; Dickerson, Bradford C; Rosen, Howard J; Miller, Bruce L; Lleó, Alberto; Gorno-Tempini, Maria Luisa; Sánchez-Valle, Raquel; Fortea, Juan In: Alzheimer's research & therapy, vol 14, iss 1 (2022) Abstract: BackgroundCortical mean diffusivity is a novel imaging metric sensitive to early changes in neurodegenerative syndromes. Higher cortical mean diffusivity values reflect microstructural disorganization and have been proposed as a sensitive biomarker that might antedate macroscopic cortical changes. We aimed to test the hypothesis that cortical mean diffusivity is more sensitive than cortical thickness to detect cortical changes in primary progressive aphasia (PPA).MethodsIn this multicenter, case-control study, we recruited 120 patients with PPA (52 non-fluent, 31 semantic, and 32 logopenic variants; and 5 GRN-related PPA) as well as 89 controls from three centers. The 3-Tesla MRI protocol included structural and diffusion-weighted sequences. Disease severity was assessed with the Clinical Dementia Rating scale. Cortical thickness and cortical mean diffusivity were computed using a surface-based approach.ResultsThe comparison between each PPA variant and controls revealed cortical mean diffusivity increases and cortical thinning in overlapping regions, reflecting the canonical loci of neurodegeneration of each variant. Importantly, cortical mean diffusivity increases also expanded to other PPA-related areas and correlated with disease severity in all PPA groups. Cortical mean diffusivity was also increased in patients with very mild PPA when only minimal cortical thinning was observed and showed a good correlation with measures of disease severity.ConclusionsCortical mean diffusivity shows promise as a sensitive biomarker for the study of the neurodegeneration-related microstructural changes in PPA. Keyword: 2.1 Biological and endogenous factors; Acquired Cognitive Impairment; Aging; Alzheimer's disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer’s disease; Aphasia; Biomedical Imaging; Brain Disorders; Case-Control Studies; Clinical Research; Dementia; Diffusion; Diffusion Magnetic Resonance Imaging; Frontotemporal Dementia (FTD); Frontotemporal lobar degeneration; Humans; Magnetic resonance; Magnetic Resonance Imaging; Medical and Health Sciences; Neurodegenerative; Neurological; Neurosciences; Primary Progressive; Primary progressive aphasia; Rare Diseases URL: https://escholarship.org/uc/item/4td346vg BASE Hide details 2 Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification. Yang, Winson FZ; Toller, Gianina; Shdo, Suzanne. - : eScholarship, University of California, 2021 BASE Show details 3 Uniform data set language measures for bvFTD and PPA diagnosis and monitoring. Staffaroni, Adam M; Weintraub, Sandra; Rascovsky, Katya... In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021) BASE Show details 4 Social Behavior Observer Checklist: Patterns of Spontaneous Behaviors Differentiate Patients With Neurodegenerative Disease From Healthy Older Adults. Rankin, Katherine P; Toller, Gianina; Gavron, Lauren. - : eScholarship, University of California, 2021 BASE Show details 5 Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification. Yang, Winson FZ; Toller, Gianina; Shdo, Suzanne. - : eScholarship, University of California, 2021 BASE Show details 6 What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia? Magrath Guimet, Nahuel; Miller, Bruce L; Allegri, Ricardo F. - : eScholarship, University of California, 2021 BASE Show details 7 Uniform data set language measures for bvFTD and PPA diagnosis and monitoring. Staffaroni, Adam M; Weintraub, Sandra; Rascovsky, Katya... In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021) BASE Show details 8 What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia? Magrath Guimet, Nahuel; Miller, Bruce L; Allegri, Ricardo F. - : eScholarship, University of California, 2021 BASE Show details 9 Amount and delay insensitivity during intertemporal choice in three neurodegenerative diseases reflects dorsomedial prefrontal atrophy. Beagle, Alexander J; Zahir, Ali; Borzello, Mia. - : eScholarship, University of California, 2020 BASE Show details 10 Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages. Shdo, Suzanne M; Ranasinghe, Kamalini G; Sturm, Virginia E. - : eScholarship, University of California, 2020 BASE Show details 11 Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages. Shdo, Suzanne M; Ranasinghe, Kamalini G; Sturm, Virginia E. - : eScholarship, University of California, 2020 BASE Show details 12 Amount and delay insensitivity during intertemporal choice in three neurodegenerative diseases reflects dorsomedial prefrontal atrophy. Beagle, Alexander J; Zahir, Ali; Borzello, Mia. - : eScholarship, University of California, 2020 BASE Show details 13 Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers. Lee, Suzee E; Sias, Ana C; Kosik, Eena L. - : eScholarship, University of California, 2019 BASE Show details 14 Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers. Lee, Suzee E; Sias, Ana C; Kosik, Eena L... In: Lee, Suzee E; Sias, Ana C; Kosik, Eena L; Flagan, Taru M; Deng, Jersey; Chu, Stephanie A; et al.(2019). Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers. NeuroImage. Clinical, 22, 101751. doi:10.1016/j.nicl.2019.101751. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6vv8g8qt (2019) BASE Show details 15 Physiological, behavioral and subjective sadness reactivity in frontotemporal dementia subtypes. Hua, Alice Y; Chen, Kuan-Hua; Brown, Casey L... In: Social cognitive and affective neuroscience, vol 14, iss 12 (2019) BASE Show details 16 Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity. Toller, Gianina; Yang, Winson FZ; Brown, Jesse A... In: Toller, Gianina; Yang, Winson FZ; Brown, Jesse A; Ranasinghe, Kamalini G; Shdo, Suzanne M; Kramer, Joel H; et al.(2019). Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity. NeuroImage. Clinical, 22, 101729. doi:10.1016/j.nicl.2019.101729. UCSF: Retrieved from: http://www.escholarship.org/uc/item/9qm527cr (2019) BASE Show details 17 Factors that predict diagnostic stability in neurodegenerative dementia. Perry, David C; Datta, Samir; Miller, Zachary A... In: Journal of neurology, vol 266, iss 8 (2019) BASE Show details 18 Factors that predict diagnostic stability in neurodegenerative dementia. Perry, David C; Datta, Samir; Miller, Zachary A... In: Journal of neurology, vol 266, iss 8 (2019) BASE Show details 19 Relationship Turmoil and Emotional Empathy in Frontotemporal Dementia. Takeda, Akitoshi; Sturm, Virginia E; Rankin, Katherine P... In: Alzheimer disease and associated disorders, vol 33, iss 3 (2019) BASE Show details 20 Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity. Toller, Gianina; Yang, Winson FZ; Brown, Jesse A. - : eScholarship, University of California, 2019 BASE Show details Page: 1 2 3

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