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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Page: 1 2 3 Hits 1 – 20 of 44 1 Comparing two facets of emotion perception across multiple neurodegenerative diseases. Brown, Casey L; Hua, Alice Y; De Coster, Lize... In: Social cognitive and affective neuroscience, vol 15, iss 5 (2020) BASE Show details 2 Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease. Chapleau, Marianne; Bedetti, Christophe; Devenyi, Gabriel A. - : eScholarship, University of California, 2020 BASE Show details 3 Comparing two facets of emotion perception across multiple neurodegenerative diseases. Brown, Casey L; Hua, Alice Y; De Coster, Lize... In: Social cognitive and affective neuroscience, vol 15, iss 5 (2020) BASE Show details 4 Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers. Lee, Suzee E; Sias, Ana C; Kosik, Eena L. - : eScholarship, University of California, 2019 BASE Show details 5 Physiological, behavioral and subjective sadness reactivity in frontotemporal dementia subtypes. Hua, Alice Y; Chen, Kuan-Hua; Brown, Casey L... In: Social cognitive and affective neuroscience, vol 14, iss 12 (2019) BASE Show details 6 Factors that predict diagnostic stability in neurodegenerative dementia. Perry, David C; Datta, Samir; Miller, Zachary A... In: Journal of neurology, vol 266, iss 8 (2019) BASE Show details 7 Factors that predict diagnostic stability in neurodegenerative dementia. Perry, David C; Datta, Samir; Miller, Zachary A... In: Journal of neurology, vol 266, iss 8 (2019) BASE Show details 8 Relationship Turmoil and Emotional Empathy in Frontotemporal Dementia. Takeda, Akitoshi; Sturm, Virginia E; Rankin, Katherine P... In: Alzheimer disease and associated disorders, vol 33, iss 3 (2019) BASE Show details 9 Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity. Toller, Gianina; Yang, Winson FZ; Brown, Jesse A. - : eScholarship, University of California, 2019 BASE Show details 10 Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers. Lee, Suzee E; Sias, Ana C; Kosik, Eena L. - : eScholarship, University of California, 2019 BASE Show details 11 Relationship Turmoil and Emotional Empathy in Frontotemporal Dementia. Takeda, Akitoshi; Sturm, Virginia E; Rankin, Katherine P... In: Alzheimer disease and associated disorders, vol 33, iss 3 (2019) BASE Show details 12 Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity. Toller, Gianina; Yang, Winson FZ; Brown, Jesse A. - : eScholarship, University of California, 2019 BASE Show details 13 Physiological, behavioral and subjective sadness reactivity in frontotemporal dementia subtypes. Hua, Alice Y; Chen, Kuan-Hua; Brown, Casey L... In: Social cognitive and affective neuroscience, vol 14, iss 12 (2019) BASE Show details 14 Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease. Ranasinghe, Kamalini G; Kothare, Hardik; Kort, Naomi; Hinkley, Leighton B; Beagle, Alexander J; Mizuiri, Danielle; Honma, Susanne M; Lee, Richard; Miller, Bruce L; Gorno-Tempini, Maria Luisa; Vossel, Keith A; Houde, John F; Nagarajan, Srikantan S In: Scientific reports, vol 9, iss 1 (2019) Abstract: Accurate integration of sensory inputs and motor commands is essential to achieve successful behavioral goals. A robust model of sensorimotor integration is the pitch perturbation response, in which speakers respond rapidly to shifts of the pitch in their auditory feedback. In a previous study, we demonstrated abnormal sensorimotor integration in patients with Alzheimer's disease (AD) with an abnormally enhanced behavioral response topitch perturbation. Here we examine the neural correlates of the abnormal pitch perturbation response in AD patients, using magnetoencephalographic imaging. The participants phonated the vowel /α/ while a real-time signal processor briefly perturbed the pitch(100 cents, 400 ms) of their auditory feedback. We examined the high-gamma band (65-150 Hz) responses during this task. AD patients showed significantly reduced left prefrontal activity during the early phase of perturbation and increased right middle temporal activity during the later phase of perturbation, compared to controls. Activity in these brain regions significantly correlated with the behavioral response. These results demonstrate that impaired prefrontal modulation of speech-motor-control network and additional recruitment of right temporal regions are significant mediators of aberrant sensorimotor integration in patients with AD. The abnormal neural integration mechanisms signify the contribution of cortical network dysfunction to cognitive and behavioral deficits in AD. Keyword: 2.1 Biological and endogenous factors; Acoustic Stimulation; Acquired Cognitive Impairment; Aging; Alzheimer Disease; Alzheimer's Disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias; Basic Behavioral and Social Science; Behavioral and Social Science; Biochemistry and Cell Biology; Brain; Brain Disorders; Clinical Research; Dementia; Feedback; Female; Humans; Male; Middle Aged; Neurodegenerative; Neurological; Neurosciences; Other Physical Sciences; Phonation; Pitch Perception; Rehabilitation; Sensory; Speech URL: https://escholarship.org/uc/item/3170w5cs BASE Hide details 15 Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease. Ranasinghe, Kamalini G; Kothare, Hardik; Kort, Naomi... In: Scientific reports, vol 9, iss 1 (2019) BASE Show details 16 Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia. Santos-Santos, Miguel A; Rabinovici, Gil D; Iaccarino, Leonardo... In: JAMA neurology, vol 75, iss 3 (2018) BASE Show details 17 Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia. Santos-Santos, Miguel A; Rabinovici, Gil D; Iaccarino, Leonardo... In: JAMA neurology, vol 75, iss 3 (2018) BASE Show details 18 Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease. Elahi, Fanny M; Marx, Gabe; Cobigo, Yann. - : eScholarship, University of California, 2017 BASE Show details 19 Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease. Elahi, Fanny M; Marx, Gabe; Cobigo, Yann. - : eScholarship, University of California, 2017 BASE Show details 20 A neural network underlying intentional emotional facial expression in neurodegenerative disease. Gola, Kelly A; Shany-Ur, Tal; Pressman, Peter. - : eScholarship, University of California, 2017 BASE Show details Page: 1 2 3

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