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1
Diminished preparatory physiological responses in frontotemporal lobar degeneration syndromes
In: Brain Commun (2022)
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2
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring
In: Alzheimers Dement (Amst) (2021)
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3
Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages
In: Front Neurol (2020)
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4
Visuospatial Functioning In The Primary Progressive Aphasias
Watson, Christa L.; Possin, Katherine; Allen, I. Elaine. - : Cambridge Univ Press, 2018
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5
Reading words and other people: a comparison of exception word, familiar face and affect processing in the left and right temporal variants of primary progressive aphasia
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6
Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia
In: Brain. - Oxford : Oxford Univ. Press 130 (2007) 4, 1159-1166
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7
The anatomy of category-specific object naming in neurodegenerative diseases
In: Journal of cognitive neuroscience. - Cambridge, Mass. : MIT Press Journals 18 (2006) 10, 1644-1653
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8
Cognition and Anatomy in Three Variants of Primary Progressive Aphasia
Abstract: We performed a comprehensive cognitive, neuroimaging, and genetic study of 31 patients with primary progressive aphasia (PPA), a decline in language functions that remains isolated for at least 2 years. Detailed speech and language evaluation was used to identify three different clinical variants: nonfluent progressive aphasia (NFPA; n = 11), semantic dementia (SD; n = 10), and a third variant termed logopenic progressive aphasia (LPA; n = 10). Voxel-based morphometry (VBM) on MRIs showed that, when all 31 PPA patients were analyzed together, the left perisylvian region and the anterior temporal lobes were atrophied. However, when each clinical variant was considered separately, distinctive patterns emerged: (1) NFPA, characterized by apraxia of speech and deficits in processing complex syntax, was associated with left inferior frontal and insular atrophy; (2) SD, characterized by fluent speech and semantic memory deficits, was associated with anterior temporal damage; and (3) LPA, characterized by slow speech and impaired syntactic comprehension and naming, showed atrophy in the left posterior temporal cortex and inferior parietal lobule. Apolipoprotein E ε4 haplotype frequency was 20% in NFPA, 0% in SD, and 67% in LPA. Cognitive, genetic, and anatomical features indicate that different PPA clinical variants may correspond to different underlying pathological processes.
Keyword: Article
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362399
https://doi.org/10.1002/ana.10825
http://www.ncbi.nlm.nih.gov/pubmed/14991811
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