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1
Longitudinal gray matter contraction in three variants of primary progressive aphasia : a tensor-based morphometry study
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2
Inflectional morphology in primary progressive aphasia: An elicited production study
In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 136 (2014), 58-68
OLC Linguistik
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3
Inflectional morphology in primary progressive aphasia: An elicited production study
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4
Elicitation of specific syntactic structures in primary progressive aphasia
In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 123 (2012) 3, 183-190
BLLDB
OLC Linguistik
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5
Neuropsychological, behavioral, and anatomical evolution in right temporal variant frontotemporal dementia: A longitudinal and post-mortem single case analysis
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6
Semantic dementia and persisting Wernicke's aphasia: linguistic and anatomical profiles
In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 117 (2011) 1, 28-33
BLLDB
OLC Linguistik
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7
White matter damage in primary progressive aphasias: a diffusion tensor tractography study
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8
White matter damage in primary progressive aphasias: a diffusion tensor tractography study
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9
Syntactic processing depends on dorsal language tracts
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10
White matter damage in primary progressive aphasias: a diffusion tensor tractography study
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11
Language networks in semantic dementia
Agosta, Federica; Henry, Roland G.; Migliaccio, Raffaella. - : Oxford University Press, 2010
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12
Connected speech production in three variants of primary progressive aphasia
Wilson, Stephen M.; Henry, Maya L.; Besbris, Max. - : Oxford University Press, 2010
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13
Connected speech production in three variants of primary progressive aphasia
Wilson, Stephen M.; Henry, Maya L.; Besbris, Max. - : Oxford University Press, 2010
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14
Language networks in semantic dementia
Abstract: Cognitive deficits in semantic dementia have been attributed to anterior temporal lobe grey matter damage; however, key aspects of the syndrome could be due to altered anatomical connectivity between language pathways involving the temporal lobe. The aim of this study was to investigate the left language-related cerebral pathways in semantic dementia using diffusion tensor imaging-based tractography and to combine the findings with cortical anatomical and functional magnetic resonance imaging data obtained during a reading activation task. The left inferior longitudinal fasciculus, arcuate fasciculus and fronto-parietal superior longitudinal fasciculus were tracked in five semantic dementia patients and eight healthy controls. The left uncinate fasciculus and the genu and splenium of the corpus callosum were also obtained for comparison with previous studies. From each tract, mean diffusivity, fractional anisotropy, as well as parallel and transverse diffusivities were obtained. Diffusion tensor imaging results were related to grey and white matter atrophy volume assessed by voxel-based morphometry and functional magnetic resonance imaging activations during a reading task. Semantic dementia patients had significantly higher mean diffusivity, parallel and transverse in the inferior longitudinal fasciculus. The arcuate and uncinate fasciculi demonstrated significantly higher mean diffusivity, parallel and transverse and significantly lower fractional anisotropy. The fronto-parietal superior longitudinal fasciculus was relatively spared, with a significant difference observed for transverse diffusivity and fractional anisotropy, only. In the corpus callosum, the genu showed lower fractional anisotropy compared with controls, while no difference was found in the splenium. The left parietal cortex did not show significant volume changes on voxel-based morphometry and demonstrated normal functional magnetic resonance imaging activation in response to reading items that stress sublexical phonological processing. This study shows that semantic dementia is associated with anatomical damage to the major superior and inferior temporal white matter connections of the left hemisphere likely involved in semantic and lexical processes, with relative sparing of the fronto-parietal superior longitudinal fasciculus. Fronto-parietal regions connected by this tract were activated normally in the same patients during sublexical reading. These findings contribute to our understanding of the anatomical changes that occur in semantic dementia, and may further help to explain the dissociation between marked single-word and object knowledge deficits, but sparing of phonology and fluency in semantic dementia.
Keyword: Original Articles
URL: http://www.ncbi.nlm.nih.gov/pubmed/19759202
https://doi.org/10.1093/brain/awp233
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801321
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15
Connected speech production in three variants of primary progressive aphasia
Wilson, Stephen M.; Henry, Maya L.; Besbris, Max. - : Oxford University Press, 2010
BASE
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16
Neural correlates of syntactic processing in the non-fluent variant of primary progressive aphasia
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17
Neuropsychological, Behavioral, and Anatomical Evolution in Right Temporal Variant Frontotemporal Dementia: A Longitudinal Single Case Analysis
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18
Language networks in semantic dementia
Agosta, Federica; Henry, Roland G.; Migliaccio, Raffaella. - : Oxford University Press, 2009
BASE
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19
The neural basis of surface dyslexia in semantic dementia
Wilson, Stephen M.; Brambati, Simona M.; Henry, Roland G.. - : Oxford University Press, 2009
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20
Automated MRI-based classification of primary progressive aphasia variants
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