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1
Longitudinal gray matter contraction in three variants of primary progressive aphasia : a tensor-based morphometry study
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2
Inflectional morphology in primary progressive aphasia: An elicited production study
In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 136 (2014), 58-68
OLC Linguistik
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3
Inflectional morphology in primary progressive aphasia: An elicited production study
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4
Elicitation of specific syntactic structures in primary progressive aphasia
In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 123 (2012) 3, 183-190
BLLDB
OLC Linguistik
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5
Neuropsychological, behavioral, and anatomical evolution in right temporal variant frontotemporal dementia: A longitudinal and post-mortem single case analysis
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6
Semantic dementia and persisting Wernicke's aphasia: linguistic and anatomical profiles
In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 117 (2011) 1, 28-33
BLLDB
OLC Linguistik
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7
White matter damage in primary progressive aphasias: a diffusion tensor tractography study
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8
White matter damage in primary progressive aphasias: a diffusion tensor tractography study
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9
Syntactic processing depends on dorsal language tracts
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10
White matter damage in primary progressive aphasias: a diffusion tensor tractography study
Abstract: Primary progressive aphasia is a clinical syndrome that encompasses three major phenotypes: non-fluent/agrammatic, semantic and logopenic. These clinical entities have been associated with characteristic patterns of focal grey matter atrophy in left posterior frontoinsular, anterior temporal and left temporoparietal regions, respectively. Recently, network-level dysfunction has been hypothesized but research to date has focused largely on studying grey matter damage. The aim of this study was to assess the integrity of white matter tracts in the different primary progressive aphasia subtypes. We used diffusion tensor imaging in 48 individuals: nine non-fluent, nine semantic, nine logopenic and 21 age-matched controls. Probabilistic tractography was used to identify bilateral inferior longitudinal (anterior, middle, posterior) and uncinate fasciculi (referred to as the ventral pathway); and the superior longitudinal fasciculus segmented into its frontosupramarginal, frontoangular, frontotemporal and temporoparietal components, (referred to as the dorsal pathway). We compared the tracts’ mean fractional anisotropy, axial, radial and mean diffusivities for each tract in the different diagnostic categories. The most prominent white matter changes were found in the dorsal pathways in non-fluent patients, in the two ventral pathways and the temporal components of the dorsal pathways in semantic variant, and in the temporoparietal component of the dorsal bundles in logopenic patients. Each of the primary progressive aphasia variants showed different patterns of diffusion tensor metrics alterations: non-fluent patients showed the greatest changes in fractional anisotropy and radial and mean diffusivities; semantic variant patients had severe changes in all metrics; and logopenic patients had the least white matter damage, mainly involving diffusivity, with fractional anisotropy altered only in the temporoparietal component of the dorsal pathway. This study demonstrates that both careful dissection of the main language tracts and consideration of all diffusion tensor metrics are necessary to characterize the white matter changes that occur in the variants of primary progressive aphasia. These results highlight the potential value of diffusion tensor imaging as a new tool in the multimodal diagnostic evaluation of primary progressive aphasia.
Keyword: Original Articles
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187537
http://www.ncbi.nlm.nih.gov/pubmed/21666264
https://doi.org/10.1093/brain/awr099
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11
Language networks in semantic dementia
Agosta, Federica; Henry, Roland G.; Migliaccio, Raffaella. - : Oxford University Press, 2010
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12
Connected speech production in three variants of primary progressive aphasia
Wilson, Stephen M.; Henry, Maya L.; Besbris, Max. - : Oxford University Press, 2010
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13
Connected speech production in three variants of primary progressive aphasia
Wilson, Stephen M.; Henry, Maya L.; Besbris, Max. - : Oxford University Press, 2010
BASE
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14
Language networks in semantic dementia
Agosta, Federica; Henry, Roland G.; Migliaccio, Raffaella. - : Oxford University Press, 2010
BASE
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15
Connected speech production in three variants of primary progressive aphasia
Wilson, Stephen M.; Henry, Maya L.; Besbris, Max. - : Oxford University Press, 2010
BASE
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16
Neural correlates of syntactic processing in the non-fluent variant of primary progressive aphasia
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17
Neuropsychological, Behavioral, and Anatomical Evolution in Right Temporal Variant Frontotemporal Dementia: A Longitudinal Single Case Analysis
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18
Language networks in semantic dementia
Agosta, Federica; Henry, Roland G.; Migliaccio, Raffaella. - : Oxford University Press, 2009
BASE
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19
The neural basis of surface dyslexia in semantic dementia
Wilson, Stephen M.; Brambati, Simona M.; Henry, Roland G.. - : Oxford University Press, 2009
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20
Automated MRI-based classification of primary progressive aphasia variants
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