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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Page: 1 2 3 Hits 1 – 20 of 43 1 Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool. ... Peterson, Katie A; Jones, P Simon; Patel, Nikil. - : Apollo - University of Cambridge Repository, 2021 BASE Show details 2 Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool ... Peterson, Katie A.; Jones, P. Simon; Patel, Nikil. - : Apollo - University of Cambridge Repository, 2021 BASE Show details 3 Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool Peterson, Katie A.; Jones, P. Simon; Patel, Nikil... In: Front Aging Neurosci (2021) BASE Show details 4 Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool Peterson, Katie A.; Jones, P. Simon; Patel, Nikil; Tsvetanov, Kamen A.; Ingram, Ruth; Cappa, Stefano F.; Lambon Ralph, Matthew A.; Patterson, Karalyn; Garrard, Peter; Rowe, James B.. - : Frontiers Media S.A., 2021. : Frontiers in Aging Neuroscience, 2021 Abstract: Background: Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) affect speech and language as well as motor functions. Clinical and neuropathological data indicate a close relationship between these two disorders and the non-fluent variant of primary progressive aphasia (nfvPPA). We use the recently developed Mini Linguistic State Examination tool (MLSE) to study speech and language disorders in patients with PSP, CBS, and nfvPPA, in combination with structural magnetic resonance imaging (MRI). Methods: Fifty-one patients (PSP N = 13, CBS N = 19, nfvPPA N = 19) and 30 age-matched controls completed the MLSE, the short form of the Boston Diagnostic Aphasia Examination (BDAE), and the Addenbrooke’s Cognitive Examination III. Thirty-eight patients and all controls underwent structural MRI at 3 Tesla, with T1 and T2-weighted images processed by surface-based and subcortical segmentation within FreeSurfer 6.0.0 to extract cortical thickness and subcortical volumes. Morphometric differences were compared between groups and correlated with the severity of speech and language impairment. Results: CBS and PSP patients showed impaired MLSE performance, compared to controls, with a similar language profile to nfvPPA, albeit less severe. All patient groups showed reduced cortical thickness in bilateral frontal regions and striatal volume. PSP and nfvPPA patients also showed reduced superior temporal cortical thickness, with additional thalamic and amygdalo-hippocampal volume reductions in nfvPPA. Multivariate analysis of brain-wide cortical thickness and subcortical volumes with MLSE domain scores revealed associations between performance on multiple speech and language domains with atrophy of left-lateralised fronto-temporal cortex, amygdala, hippocampus, putamen, and caudate. Conclusions: The effect of PSP and CBS on speech and language overlaps with nfvPPA. These three disorders cause a common anatomical pattern of atrophy in the left frontotemporal language network and striatum. The MLSE is a short clinical screening tool that can identify the language disorder of PSP and CBS, facilitating clinical management and patient access to future clinical trials. Keyword: aphasia; corticobasal syndrome; language; Neuroscience; progressive supranuclear palsy; speech URL: https://www.repository.cam.ac.uk/handle/1810/326597 https://doi.org/10.17863/CAM.74046 BASE Hide details 5 Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool. Peterson, Katie A; Jones, P Simon; Patel, Nikil... In: essn: 1663-4365 ; nlmid: 101525824 (2021) BASE Show details 6 Graded, multidimensional intra- and intergroup variations in primary progressive aphasia and post-stroke aphasia. Ingram, Ruth U; Halai, Ajay D; Pobric, Gorana... In: Brain : a journal of neurology, vol 143, iss 10 (2020) BASE Show details 7 Redefining the multidimensional clinical phenotypes of frontotemporal lobar degeneration syndromes Murley, Alexander G; Coyle-Gilchrist, Ian; Rouse, Matthew A... In: Brain (2020) BASE Show details 8 Disorders of representation and control in semantic cognition : Effects of familiarity, typicality, and specificity Rogers, Timothy T.; Patterson, Karalyn; Jefferies, Elizabeth. - 2015 BASE Show details 9 Disorders of representation and control in semantic cognition: Effects of familiarity, typicality, and specificity Rogers, Timothy T.; Patterson, Karalyn; Jefferies, Elizabeth. - : Pergamon Press, 2015 BASE Show details 10 Finite case series or infinite single-case studies? Comments on "Case series investigations in cognitive neuropsychologyʺ by Schwartz and Dell (2010) Plaut, David C.; Patterson, Karalyn; Lambon Ralph, Matthew A. In: Cognitive neuropsychology. - Abingdon : Routledge, Taylor & Francis Group 28 (2011) 7-8, 466-474 BLLDB OLC Linguistik Show details 11 The role of conceptual knowledge in object use : evidence from semantic dementia Hodges, John R.; Bozeat, Sasha; Lambon Ralph, Matthew A.... In: Cognitive neuroscience (New York, 2009), 2 ; 482-504 MPI für Psycholinguistik Show details 12 Comprehension of concrete and abstract words in semantic dementia Jefferies, Elizabeth; Patterson, Karalyn; Jones, Roy W.. - 2009 BASE Show details 13 Deficits of knowledge vs. executive control in semantic cognition: Insights from cued naming Jefferies, Elizabeth; Patterson, Karalyn; Lambon Ralph, Matthew A.. - 2007 BASE Show details 14 Progressive non-fluent aphasia is not a progressive form of non-fluent (post-stroke) aphasia Patterson, Karalyn; Hodges, John R.; Lambon Ralph, Matthew A.... In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 20 (2006) 9-11, 1018-1034 BLLDB OLC Linguistik Show details 15 'Presemantic' cognition in semantic dementia : six deficits in search of an explanation Lambon Ralph, Matthew A.; Hodges, John R.; Jones, Roy W.... In: Journal of cognitive neuroscience. - Cambridge, Mass. : MIT Press Journals 18 (2006) 2, 169-183 BLLDB OLC Linguistik Show details 16 The relationship between phonological and morphological deficits in Broca#8217s aphasia: Further evidence from errors in verb inflection Braber, Natalie; Patterson, Karalyn; Ellis, Katherine... In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 92 (2005) 3, 278-287 OLC Linguistik Show details 17 Semantic feature knowledge and picture naming in dementia of Alzheimer#8217s type: A new approach Garrard, Peter; Lambon Ralph, Matthew A.; Patterson, Karalyn... In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 93 (2005) 1, 79-94 OLC Linguistik Show details 18 What underlies the neuropsychological pattern of irregular>regular past-tense verb production? Lambon Ralph, Matthew A.; Braber, Natalie; Mcclelland, James L.... In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 93 (2005) 1, 106-119 OLC Linguistik Show details 19 The relationship between phonological and morphological deficits in Broca's aphasia : further evidence from errors in verb inflection Braber, Natalie; Patterson, Karalyn; Ellis, Katherine... In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 92 (2005) 3, 278-287 BLLDB Show details 20 What underlies the neuropsychological pattern of irregular > regular past-tense verb production? Lambon Ralph, Matthew A.; Braber, Natalie; McClelland, James L.... In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 93 (2005) 1, 106-119 BLLDB Show details Page: 1 2 3

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