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Hits 1 – 4 of 4
1
Effets de la L-dopa et de la stimulation du noyau subthalamique sur la coordination pneumophonique dans la dysarthrie parkinsonienne: mesures de la pression intra-orale
Sarr, Mamadou Moustapha
;
Pinto, Serge
;
Jankowski, Ludovic
...
In: Journées de Phonétique Clinique ; https://hal.archives-ouvertes.fr/hal-01615342 ; Journées de Phonétique Clinique, 2009, Aix-en-Provence, France (2009)
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2
L-dopa and STN stimulation effects on pneumophonic coordination in Parkinsonian dysarthria: intra-oral pressure measurements
Sarr, Moustapha
;
Pinto, Serge
;
Jankowski, Ludovic
;
Purson, Alain
;
Ghio, Alain
;
Espesser, Robert
;
Teston, Bernard
;
Viallet, François
In: International Congress of Parkinson's Disease and Movement Disorders ; https://hal.archives-ouvertes.fr/hal-01615372 ; International Congress of Parkinson's Disease and Movement Disorders, Movement Disorder Society's, 2009, Paris, France (2009)
Abstract:
International audience ; Objective: To evaluate L-dopa and STN stimulation effects on pneumophonic coordination (PC) in Parkinson's disease (PD), bystudying the temporal progression of intra-oral pressure (IOP) during the expiratory phase of a sentence production.Background: Effects of L-dopa and STN stimulation on Parkinsonian dysarthria still remain erratic and challenging for theclinician. As the PC plays a crucial role in the sound pressure level production, then contributing largely to speech intelligibility,it is important to assess this aspect of speech in PD and to quantify the changes that may be expected following treatments.Methods: Using a dedicated system (EVA2, SQLAb, Aix-en-Provence), 24 PD patients were recorded preoperatively on and offL-dopa, as well as postoperatively ON and OFF STN stimulation. IOP on six measurement points (every p consonants) duringrealisation of the French sentence Papa ne m'a pas parl de beau-papa (Daddy did not speak to me about daddy-in-law) wascalculated. Fifty control subjects were recorded in parallel in order to define the reference. A linear mixed model was estimated( R software, version 2.6.2, http://www.r-project.org) for group analyses integrating patient and p consonant as randomterms and treatment nature (L-dopa vs. STN stimulation) and state (off vs. on) as fixed effects.Results: UPDRS motor scores and IOP measurements displayed significant differences (p<0.05) between off and on states,either with L-dopa or STN stimulation. Differences between on and off states could not be distinguished from L-dopa and STNstimulation treatments. Regards to IOP measurements, significant differences were found between control subjects and patientsOFF stimulation, ON stimulation and off L-dopa. No difference was revealed between controls and patients on L-dopa.Conclusions: L-dopa administration led to patient IOP values closer to controls in comparison with the STN stimulation ONstate: this point deserves attention since it confirms the frequent need for treatment combination following surgery. However,the levels of PC improvement by L-dopa preoperatively and STN stimulation postoperatively are not statistically different,highlighting the controversial effect of treatments on axial signs.
Keyword:
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
;
[SHS.LANGUE]Humanities and Social Sciences/Linguistics
;
Aérodynamique
;
Dysarthria
;
Dysarthrie
;
Evaluation instrumentale
;
Levodopa (L-dopa)
;
Parkinson
;
Parole
;
Phonétique Clinique
;
Speech
;
Subthalamic nucleus (SIN)
URL:
https://hal.archives-ouvertes.fr/hal-01615372
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3
Corpus de parole pathologique, état d'avancement et enjeux méthodologiques
Ghio, Alain
;
Teston, Bernard
;
Viallet, François
...
In: ISSN: 2118-870X ; EISSN: 2264-7082 ; Travaux Interdisciplinaires du Laboratoire Parole et Langage d'Aix-en-Provence (TIPA) ; https://hal.archives-ouvertes.fr/hal-00354505 ; Travaux Interdisciplinaires du Laboratoire Parole et Langage d'Aix-en-Provence (TIPA), Laboratoire Parole et Langage, 2006, 25, pp.109-126 (2006)
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4
Corpus de 'parole pathologique': état d'avancement et enjeux methodologiques au LPL
Ghio, Alain
;
Viallet, François
;
Jankowski, Ludovic
...
In:
Université de Provence / Laboratoire parole et langage. Travaux interdisciplinaires du Laboratoire Parole et Langage d'Aix-en-Provence. - Aix-en-Provence
25 (2006), 109-126
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