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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 4 of 4 1 Comparative semantic profiles in semantic dementia and Alzheimer's disease Libon, David J.; Rascovsky, Katya; Powers, John. - : Oxford University Press, 2013 BASE Show details 2 Sparse canonical correlation analysis relates network-level atrophy to multivariate cognitive measures in a neurodegenerative population Avants, Brian B.; Libon, David J.; Rascovsky, Katya; Boller, Ashley; McMillan, Corey T.; Massimo, Lauren; Coslett, H. Branch; Chatterjee, Anjan; Gross, Rachel G.; Grossman, Murray. - 2013 Abstract: This study establishes that sparse canonical correlation analysis (SCCAN) identifies generalizable, structural MRI-derived cortical networks that relate to five distinct categories of cognition. We obtain multivariate psychometrics from the domain-specific sub-scales of the Philadelphia Brief Assessment of Cognition (PBAC). By using a training and separate testing stage, we find that PBAC-defined cognitive domains of language, visuospatial functioning, episodic memory, executive control, and social functioning correlate with unique and distributed areas of gray matter (GM). In contrast, a parallel univariate framework fails to identify, from the training data, regions that are also significant in the left-out test dataset. The cohort includes164 patients with Alzheimer’s disease, behavioral-variant frontotemporal dementia, semantic variant primary progressive aphasia, nonfluent/agrammatic primary progressive aphasia, or corticobasal syndrome. The analysis is implemented with open-source software for which we provide examples in the text. In conclusion, we show that multivariate techniques identify biologically-plausible brain regions supporting specific cognitive domains. The findings are identified in training data and confirmed in test data. Keyword: Article URL: https://doi.org/10.1016/j.neuroimage.2013.09.048 http://www.ncbi.nlm.nih.gov/pubmed/24096125 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911786 BASE Hide details 3 Comparative semantic profiles in semantic dementia and Alzheimer’s disease Libon, David J.; Rascovsky, Katya; Powers, John. - : Oxford University Press, 2013 BASE Show details 4 The Philadelphia Brief Assessment of Cognition (PBAC): A Validated Screening Measure for Dementia Libon, David J.; Rascovsky, Katya; Gross, Rachel G.. - 2011 BASE Show details

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