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    • SEMANTIC DEMENTIA (9)
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    • Rohrer, JD (9)
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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 9 of 9 1 Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia Rascovsky, K; Hodges, JR; Knopman, D... In: BRAIN , 134 2456 - 2477. (2011) (2011) BASE Show details 2 Measuring disease progression in frontotemporal lobar degeneration A clinical and MRI study Gordon, E; Rohrer, JD; Kim, LG... In: NEUROLOGY , 74 (8) 666 - 673. (2010) (2010) BASE Show details 3 Phenomenology and anatomy of abnormal behaviours in primary progressive aphasia Rohrer, JD; Warren, JD In: J NEUROL SCI , 293 (1-2) 35 - 38. (2010) (2010) BASE Show details 4 Reduced Cortical Thickness in the Posterior Cingulate Gyrus is Characteristic of Both Typical and Atypical Alzheimer's Disease Lehmann, M; Rohrer, JD; Clarkson, MJ... In: J ALZHEIMERS DIS , 20 (2) 587 - 598. (2010) (2010) BASE Show details 5 Progranulin-associated primary progressive aphasia: A distinct phenotype? Rohrer, JD; Crutch, SJ; Warrington, EK... In: NEUROPSYCHOLOGIA , 48 (1) 288 - 297. (2010) (2010) BASE Show details 6 Progressive logopenic/phonological aphasia: Erosion of the language network Rohrer, JD; Ridgway, GR; Crutch, SJ... In: NEUROIMAGE , 49 (1) 984 - 993. (2010) (2010) BASE Show details 7 Non-verbal sound processing in the primary progressive aphasias Goll, JC; Crutch, SJ; Loo, JHY... In: BRAIN , 133 272 - 285. (2010) (2010) BASE Show details 8 Patterns of cortical thinning in the language variants of frontotemporal lobar degeneration Rohrer, JD; Warren, JD; Modat, M... In: NEUROLOGY , 72 (18) 1562 - 1569. (2009) (2009) BASE Show details 9 Word-finding difficulty: a clinical analysis of the progressive aphasias Rohrer, JD; Knight, WD; Warren, JE; Fox, NC; Rossor, MN; Warren, JD In: BRAIN , 131 8 - 38. (2008) (2008) Abstract: The patient with word-finding difficulty presents a common and challenging clinical problem. The complaint of word-finding difficulty covers a wide range of clinical phenomena and may signify any of a number of distinct pathophysiological processes. Although it occurs in a variety of clinical contexts, word-finding difficulty generally presents a diagnostic conundrum when it occurs as a leading or apparently isolated symptom, most often as the harbinger of degenerative disease: the progressive aphasias. Recent advances in the neurobiology of the focal, language-based dementias have transformed our understanding of these processes and the ways in which they breakdown in different diseases, but translation of this knowledge to the bedside is far from straightforward. Speech and language disturbances in the dementias present unique diagnostic and conceptual problems that are not fully captured by classical models derived from the study of vascular and other acute focal brain lesions. This has led to a reformulation of our understanding of how language is organized in the brain. In this review we seek to provide the clinical neurologist with a practical and theoretical bridge between the patient presenting with word-finding difficulty in the clinic and the evidence of the brain sciences. We delineate key illustrative speech and language syndromes in the degenerative dementias, compare these syndromes with the syndromes of acute brain damage, and indicate how the clinical syndromes relate to emerging neurolinguistic, neuroanatomical and neurobiological insights. We propose a conceptual framework for the analysis of word-finding difficulty, in order both better to define the patients complaint and its differential diagnosis for the clinician and to identify unresolved issues as a stimulus to future work. Keyword: ALZHEIMERS-DISEASE; anomia; aphasia; CORTICOBASAL DEGENERATION; dementia; DYNAMIC APHASIA; FRONTOTEMPORAL LOBAR DEGENERATION; MOTOR-NEURON DISEASE; NONFLUENT APHASIA; POSTERIOR CORTICAL ATROPHY; progressive aphasia; SELECTIVE IMPAIRMENT; SEMANTIC DEMENTIA; speech and language; TEMPORAL-LOBE URL: http://discovery.ucl.ac.uk/143041/ BASE Hide details

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