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1
Findings of Impaired Hearing in Patients With Nonfluent/Agrammatic Variant Primary Progressive Aphasia.
Hardy, CJD; Frost, C; Sivasathiaseelan, H. - : American Medical Association, 2019
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2
Impaired Interoceptive Accuracy in Semantic Variant Primary Progressive Aphasia
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3
Behavioural and neuroanatomical correlates of auditory speech analysis in primary progressive aphasias
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4
Primary progressive aphasia: a clinical approach
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5
The TMEM106B risk allele is associated with lower cortical volumes in a clinically diagnosed frontotemporal dementia cohort.
In: J Neurol Neurosurg Psychiatry (2017) (2017)
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6
Processing emotion from abstract art in frontotemporal lobar degeneration
In: Neuropsychologia , 81 pp. 245-254. (2016) (2016)
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7
Binary reversals in primary progressive aphasia
In: Cortex , 82 pp. 287-289. (2016) (2016)
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8
Pain and temperature processing in dementia: a clinical and neuroanatomical analysis
In: Brain , 138 (11) pp. 3360-3372. (2015) (2015)
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9
The Language Profile of Behavioral Variant Frontotemporal Dementia
In: Journal of Alzheimer's Disease , 50 (2) pp. 359-371. (2015) (2015)
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10
Delayed auditory feedback simulates features of nonfluent primary progressive aphasia.
In: J Neurol Sci , 347 (1-2) 345 - 348. (2014) (2014)
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11
Delayed auditory feedback simulates features of nonfluent primary progressive aphasia
In: Journal of the Neurological Sciences , 347 (1-2) 345 - 348. (2014) (2014)
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12
Patterns of longitudinal brain atrophy in the logopenic variant of primary progressive aphasia
In: Brain and Language , 127 (2) 121 - 126. (2013) (2013)
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13
Exome sequencing reveals a novel partial deletion in the progranulin gene causing primary progressive aphasia.
In: J Neurol Neurosurg Psychiatry , 84 (12) pp. 1411-1412. (2013) (2013)
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14
Frontotemporal dementia
In: BMJ , 347 , Article f4827 . (2013) (2013)
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15
PARIETAL CONTRIBUTIONS TO LANGUAGE PROCESSING: PROGRESSIVE APHASIA IN POSTERIOR CORTICAL ATROPHY
Crutch, S; Lehmann, M; Warrington, EK. - : BMJ Publishing Group Ltd, 2012
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16
Alzheimer's pathology in primary progressive aphasia.
In: Neurobiol Aging , 33 (4) pp. 744-752. (2012) (2012)
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17
PARIETAL CONTRIBUTIONS TO LANGUAGE PROCESSING: PROGRESSIVE APHASIA IN POSTERIOR CORTICAL ATROPHY
In: In: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. (2012) (2012)
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18
Receptive prosody in nonfluent primary progressive aphasias.
In: Cortex , 48 (3) 308 - 316. (2012) (2012)
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19
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
In: BRAIN , 134 2456 - 2477. (2011) (2011)
Abstract: Based on the recent literature and collective experience, an international consortium developed revised guidelines for the diagnosis of behavioural variant frontotemporal dementia. The validation process retrospectively reviewed clinical records and compared the sensitivity of proposed and earlier criteria in a multi-site sample of patients with pathologically verified frontotemporal lobar degeneration. According to the revised criteria, 'possible' behavioural variant frontotemporal dementia requires three of six clinically discriminating features (disinhibition, apathy/inertia, loss of sympathy/empathy, perseverative/compulsive behaviours, hyperorality and dysexecutive neuropsychological profile). 'Probable' behavioural variant frontotemporal dementia adds functional disability and characteristic neuroimaging, while behavioural variant frontotemporal dementia 'with definite frontotemporal lobar degeneration' requires histopathological confirmation or a pathogenic mutation. Sixteen brain banks contributed cases meeting histopathological criteria for frontotemporal lobar degeneration and a clinical diagnosis of behavioural variant frontotemporal dementia, Alzheimer's disease, dementia with Lewy bodies or vascular dementia at presentation. Cases with predominant primary progressive aphasia or extra-pyramidal syndromes were excluded. In these autopsy-confirmed cases, an experienced neurologist or psychiatrist ascertained clinical features necessary for making a diagnosis according to previous and proposed criteria at presentation. Of 137 cases where features were available for both proposed and previously established criteria, 118 (86%) met 'possible' criteria, and 104 (76%) met criteria for 'probable' behavioural variant frontotemporal dementia. In contrast, 72 cases (53%) met previously established criteria for the syndrome (P < 0.001 for comparison with 'possible' and 'probable' criteria). Patients who failed to meet revised criteria were significantly older and most had atypical presentations with marked memory impairment. In conclusion, the revised criteria for behavioural variant frontotemporal dementia improve diagnostic accuracy compared with previously established criteria in a sample with known frontotemporal lobar degeneration. Greater sensitivity of the proposed criteria may reflect the optimized diagnostic features, less restrictive exclusion features and a flexible structure that accommodates different initial clinical presentations. Future studies will be needed to establish the reliability and specificity of these revised diagnostic guidelines.
Keyword: ALZHEIMERS-DISEASE; behavioural variant frontotemporal dementia; CEREBRAL-BLOOD-FLOW; diagnostic criteria; FRONTAL ASSESSMENT BATTERY; frontotemporal lobar degeneration; FTD; LOBAR DEGENERATION; NEURODEGENERATIVE DISEASE; NEUROPSYCHIATRIC SYMPTOMS; pathology; PICKS-DISEASE; SEMANTIC DEMENTIA; TEMPORAL VARIANTS; VASCULAR DEMENTIA
URL: http://discovery.ucl.ac.uk/1325627/
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20
Apraxia in progressive nonfluent aphasia
In: J NEUROL , 257 (4) 569 - 574. (2010) (2010)
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