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Neuroplasticity of language networks in aphasia: advances, updates, and future challenges
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2
Neurocognitive Recovery of Sentence Processing in Aphasia
Thompson, Cynthia K.. - : American Speech-Language-Hearing Association, 2019
Abstract: PURPOSE: Reorganization of language networks in aphasia takes advantage of the facts that (a) the brain is an organ of plasticity, with neuronal changes occurring throughout the life span, including following brain damage; (b) plasticity is highly experience dependent; and (c) as with any learning system, language reorganization involves a synergistic interplay between organism-intrinsic (i.e., cognitive and brain) and organism-extrinsic (i.e., environmental) variables. A major goal for clinical treatment of aphasia is to be able to prescribe treatment and predict its outcome based on the neurocognitive deficit profiles of individual patients. This review article summarizes the results of research examining the neurocognitive effects of psycholinguistically based treatment (i.e., Treatment of Underlying Forms; Thompson & Shapiro, 2005) for sentence processing impairments in individuals with chronic agrammatic aphasia resulting from stroke and primary progressive aphasia and addresses both behavioral and brain variables related to successful treatment outcomes. The influences of lesion volume and location, perfusion (blood flow), and resting-state neural activity on language recovery are also discussed as related to recovery of agrammatism and other language impairments. Based on these and other data, principles for promoting neuroplasticity of language networks are presented. CONCLUSIONS: Sentence processing treatment results in improved comprehension and production of complex syntactic structures in chronic agrammatism and generalization to less complex, linguistically related structures in chronic agrammatism. Patients also show treatment-induced shifts toward normal-like online sentence processing routines (based on eye movement data) and changes in neural recruitment patterns (based on functional neuroimaging), with posttreatment activation of regions overlapping with those within sentence processing and dorsal attention networks engaged by neurotypical adults performing the same task. These findings provide compelling evidence that treatment focused on principles of neuroplasticity promotes neurocognitive recovery in chronic agrammatic aphasia. PRESENTATION VIDEO: https://doi.org/10.23641/asha.10257587
Keyword: Forum: Advances in Neuroplasticity Research on Language Recovery in Aphasia
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203523/
http://www.ncbi.nlm.nih.gov/pubmed/31756151
https://doi.org/10.1044/2019_JSLHR-L-RSNP-19-0219
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3
Right hemisphere grey matter volume and language functions in stroke aphasia
Lukic, Sladjana; Barbieri, Elena; Wang, Xue. - : Hindawi Publishing Corporation, 2017
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4
Neuroimaging in aphasia treatment research: quantifying brain lesions after stroke
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5
Neuroimaging in aphasia treatment research: Consensus and practical guidelines for data analysis
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6
Neuroimaging in aphasia treatment research: Standards for establishing the effects of treatment
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7
Tracking passive sentence comprehension in agrammatic aphasia
In: Journal of neurolinguistics. - Orlando, Fla. : Elsevier 25 (2012) 1, 31-43
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8
Dissociations between fluency and agrammatism in primary progressive aphasia
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 26 (2012) 1, 20-43
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9
Verb and noun deficits in stroke-induced and primary progressive aphasia: the "Northwestern Naming Battery"
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 26 (2012) 5, 632-655
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10
Verb and sentence production and comprehension in aphasia: Northwestern Assessment of Verbs and Sentences (NAVS)
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 26 (2012) 10, 1250-1277
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11
Semantic interference during object naming in agrammatic and logopenic primary progressive aphasia (PPA)
In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 120 (2012) 3, 237-250
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12
Time reference in agrammatic aphasia: a cross-linguistic study
In: Journal of neurolinguistics. - Orlando, Fla. : Elsevier 24 (2011) 6, 652-673
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13
Real-time production of unergative and unaccusative sentences in normal and agrammatic speakers: an eyetracking study
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 25 (2011) 6-7, 813-825
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14
Real-time production of arguments and adjuncts in normal and agrammatic speakers
In: Language and cognitive processes. - Abingdon : Routledge, Taylor & Francis Group 26 (2011) 8, 985-1021
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15
The use of the picture-word interference paradigm to examine naming abilities in aphasic individuals
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 24 (2010) 5, 580-611
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16
Binding in agrammatic aphasia: processing to comprehension
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 24 (2010) 5, 551-579
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17
What goes wrong during passive sentence production in agrammatic aphasia: an eyetracking study
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 24 (2010) 12, 1576-1592
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18
Sentactics: computer-automated treatment of underlying forms
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 24 (2010) 10, 1242-1266
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19
Neural mechanisms of verb argument structure processing in agrammatic aphasic and healthy age-matched listeners
In: Journal of cognitive neuroscience. - Cambridge, Mass. : MIT Press Journals 22 (2010) 9, 1993-2011
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20
Production latencies of morphologically simple and complex verbs in aphasia
In: Clinical linguistics & phonetics. - London : Informa Healthcare 24 (2010) 12, 963-979
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