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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Page: 1 2 3 Hits 1 – 20 of 45 1 Tractography of supplementary motor area projections in progressive speech apraxia and aphasia Valls Carbo, Adrian; Reid, Robert I.; Tosakulwong, Nirubol... In: Neuroimage Clin (2022) BASE Show details 2 A Preliminary Report of Network Electroencephalographic Measures in Primary Progressive Apraxia of Speech and Aphasia Utianski, Rene L.; Botha, Hugo; Caviness, John N.... In: Brain Sci (2022) BASE Show details 3 Progressive Apraxia of Speech: Delays to Diagnosis and Rates of Alternative Diagnoses Dang, Johnny; Graff-Radford, Jonathan; Duffy, Joseph R.... In: J Neurol (2021) BASE Show details 4 A molecular pathology, neurobiology, biochemical, genetic and neuroimaging study of progressive apraxia of speech Josephs, Keith A.; Duffy, Joseph R.; Clark, Heather M.; Utianski, Rene L.; Strand, Edythe A.; Machulda, Mary M.; Botha, Hugo; Martin, Peter R.; Pham, Nha Trang Thu; Stierwalt, Julie; Ali, Farwa; Buciuc, Marina; Baker, Matthew; Fernandez De Castro, Cristhoper H.; Spychalla, Anthony J.; Schwarz, Christopher G.; Reid, Robert I.; Senjem, Matthew L.; Jack, Clifford R.; Lowe, Val J.; Bigio, Eileen H.; Reichard, Ross R.; Polley, Eric. J.; Ertekin-Taner, Nilufer; Rademakers, Rosa; DeTure, Michael A.; Ross, Owen A.; Dickson, Dennis W.; Whitwell, Jennifer L. In: Nat Commun (2021) Abstract: Progressive apraxia of speech is a neurodegenerative syndrome affecting spoken communication. Molecular pathology, biochemistry, genetics, and longitudinal imaging were investigated in 32 autopsy-confirmed patients with progressive apraxia of speech who were followed over 10 years. Corticobasal degeneration and progressive supranuclear palsy (4R-tauopathies) were the most common underlying pathologies. Perceptually distinct speech characteristics, combined with age-at-onset, predicted specific 4R-tauopathy; phonetic subtype and younger age predicted corticobasal degeneration, and prosodic subtype and older age predicted progressive supranuclear palsy. Phonetic and prosodic subtypes showed differing relationships within the cortico-striato-pallido-nigro-luysial network. Biochemical analysis revealed no distinct differences in aggregated 4R-tau while tau H1 haplotype frequency (69%) was lower compared to 1000+ autopsy-confirmed 4R-tauopathies. Corticobasal degeneration patients had faster rates of decline, greater cortical degeneration, and shorter illness duration than progressive supranuclear palsy. These findings help define the pathobiology of progressive apraxia of speech and may have consequences for development of 4R-tau targeting treatment. Keyword: Article URL: http://www.ncbi.nlm.nih.gov/pubmed/34103532 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187627/ https://doi.org/10.1038/s41467-021-23687-8 BASE Hide details 5 Lewy body disease is a contributor to logopenic progressive aphasia phenotype Buciuc, Marina; Whitwell, Jennifer L.; Kasanuki, Koji... In: Ann Neurol (2020) BASE Show details 6 Association of amyloid angiopathy with microbleeds in logopenic progressive aphasia: an imaging-pathology study Buciuc, Marina; Duffy, Joseph R.; Machulda, Mary M.... In: Eur J Neurol (2020) BASE Show details 7 Dementia with Lewy bodies presenting as Logopenic Variant Primary Progressive Aphasia Boes, Samuel; Botha, Hugo; Machulda, Mary... In: Neurocase (2020) BASE Show details 8 Longitudinal anatomic, functional, and molecular characterization of Pick disease phenotypes Whitwell, Jennifer L.; Tosakulwong, Nirubol; Schwarz, Christopher C.... In: Neurology (2020) BASE Show details 9 Clinical and Neuroimaging Characteristics of Clinically Unclassifiable Primary Progressive Aphasia Utianski, Rene L.; Botha, Hugo; Martin, Peter R.... In: Brain Lang (2019) BASE Show details 10 The influence of β-amyloid on [(18)F]AV-1451 in semantic variant of primary progressive aphasia Whitwell, Jennifer L.; Martin, Peter R.; Duffy, Joseph R.. - : Lippincott Williams & Wilkins, 2019 BASE Show details 11 Molecular Neuroimaging in an Agraphia Predominant Primary Progressive Aphasia Utianski, Rene L.; Duffy, Joseph R.; Savica, Rodolfo. - 2018 BASE Show details 12 Electroencephalography in Primary Progressive Aphasia and Apraxia of Speech Utianski, Rene L.; Caviness, John N.; Worrell, Gregory A.. - 2018 BASE Show details 13 Patterns of Neuropsychological Dysfunction and Cortical Volume Changes in Logopenic Aphasia Owens, Tyler E.; Machulda, Mary M.; Duffy, Joseph R.. - 2018 BASE Show details 14 [18F]AV-1451 tau-PET and primary progressive aphasia Josephs, Keith A.; Martin, Peter R.; Botha, Hugo. - 2018 BASE Show details 15 Tau Uptake in Agrammatic Primary Progressive Aphasia with and without Apraxia of Speech Utianski, Rene L.; Whitwell, Jennifer L.; Schwarz, Christopher G.. - 2018 BASE Show details 16 Quantitative assessment of grammar in amyloid-negative logopenic aphasia Tetzloff, Katerina A.; Whitwell, Jennifer L.; Utianski, Rene L.. - 2018 BASE Show details 17 Disrupted functional connectivity in primary progressive apraxia of speech Botha, Hugo; Utianski, Rene L.; Whitwell, Jennifer L.. - : Elsevier, 2018 BASE Show details 18 Tau-PET imaging with [18F]AV-1451 in Primary Progressive Apraxia of Speech Utianski, Rene L.; Whitwell, Jennifer L.; Schwarz, Christopher G.. - 2018 BASE Show details 19 Prosodic and Phonetic Subtypes of Primary Progressive Apraxia of Speech Utianski, Rene L.; Duffy, Joseph R.; Clark, Heather M.. - 2018 BASE Show details 20 Predicting clinical decline in progressive agrammatic aphasia and apraxia of speech Whitwell, Jennifer L.; Weigand, Stephen D.; Duffy, Joseph R.. - : Lippincott Williams & Wilkins, 2017 BASE Show details Page: 1 2 3

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