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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Page: 1 2 3 Hits 1 – 20 of 45 1 Tractography of supplementary motor area projections in progressive speech apraxia and aphasia Valls Carbo, Adrian; Reid, Robert I.; Tosakulwong, Nirubol... In: Neuroimage Clin (2022) BASE Show details 2 A Preliminary Report of Network Electroencephalographic Measures in Primary Progressive Apraxia of Speech and Aphasia Utianski, Rene L.; Botha, Hugo; Caviness, John N.... In: Brain Sci (2022) BASE Show details 3 Progressive Apraxia of Speech: Delays to Diagnosis and Rates of Alternative Diagnoses Dang, Johnny; Graff-Radford, Jonathan; Duffy, Joseph R.... In: J Neurol (2021) BASE Show details 4 A molecular pathology, neurobiology, biochemical, genetic and neuroimaging study of progressive apraxia of speech Josephs, Keith A.; Duffy, Joseph R.; Clark, Heather M.... In: Nat Commun (2021) BASE Show details 5 Lewy body disease is a contributor to logopenic progressive aphasia phenotype Buciuc, Marina; Whitwell, Jennifer L.; Kasanuki, Koji... In: Ann Neurol (2020) BASE Show details 6 Association of amyloid angiopathy with microbleeds in logopenic progressive aphasia: an imaging-pathology study Buciuc, Marina; Duffy, Joseph R.; Machulda, Mary M.... In: Eur J Neurol (2020) BASE Show details 7 Dementia with Lewy bodies presenting as Logopenic Variant Primary Progressive Aphasia Boes, Samuel; Botha, Hugo; Machulda, Mary... In: Neurocase (2020) BASE Show details 8 Longitudinal anatomic, functional, and molecular characterization of Pick disease phenotypes Whitwell, Jennifer L.; Tosakulwong, Nirubol; Schwarz, Christopher C.... In: Neurology (2020) BASE Show details 9 Clinical and Neuroimaging Characteristics of Clinically Unclassifiable Primary Progressive Aphasia Utianski, Rene L.; Botha, Hugo; Martin, Peter R.... In: Brain Lang (2019) BASE Show details 10 The influence of β-amyloid on [(18)F]AV-1451 in semantic variant of primary progressive aphasia Whitwell, Jennifer L.; Martin, Peter R.; Duffy, Joseph R.. - : Lippincott Williams & Wilkins, 2019 BASE Show details 11 Molecular Neuroimaging in an Agraphia Predominant Primary Progressive Aphasia Utianski, Rene L.; Duffy, Joseph R.; Savica, Rodolfo. - 2018 BASE Show details 12 Electroencephalography in Primary Progressive Aphasia and Apraxia of Speech Utianski, Rene L.; Caviness, John N.; Worrell, Gregory A.. - 2018 BASE Show details 13 Patterns of Neuropsychological Dysfunction and Cortical Volume Changes in Logopenic Aphasia Owens, Tyler E.; Machulda, Mary M.; Duffy, Joseph R.. - 2018 BASE Show details 14 [18F]AV-1451 tau-PET and primary progressive aphasia Josephs, Keith A.; Martin, Peter R.; Botha, Hugo. - 2018 BASE Show details 15 Tau Uptake in Agrammatic Primary Progressive Aphasia with and without Apraxia of Speech Utianski, Rene L.; Whitwell, Jennifer L.; Schwarz, Christopher G.. - 2018 BASE Show details 16 Quantitative assessment of grammar in amyloid-negative logopenic aphasia Tetzloff, Katerina A.; Whitwell, Jennifer L.; Utianski, Rene L.. - 2018 BASE Show details 17 Disrupted functional connectivity in primary progressive apraxia of speech Botha, Hugo; Utianski, Rene L.; Whitwell, Jennifer L.; Duffy, Joseph R.; Clark, Heather M.; Strand, Edythe A.; Machulda, Mary M.; Tosakulwong, Nirubol; Knopman, David S.; Petersen, Ronald C.; Jack, Clifford R.; Josephs, Keith A.; Jones, David T.. - : Elsevier, 2018 Abstract: Apraxia of speech is a motor speech disorder thought to result from impaired planning or programming of articulatory movements. It can be the initial or only manifestation of a degenerative disease, termed primary progressive apraxia of speech (PPAOS). The aim of this study was to use task-free functional magnetic resonance imaging (fMRI) to assess large-scale brain network pathophysiology in PPAOS. Twenty-two PPAOS participants were identified from a prospective cohort of degenerative speech and language disorders patients. All participants had a comprehensive, standardized evaluation including an evaluation by a speech-language pathologist, examination by a behavioral neurologist and a multimodal imaging protocol which included a task-free fMRI sequence. PPAOS participants were age and sex matched to amyloid-negative, cognitively normal participants with a 1:2 ratio. We chose a set of hypothesis driven, predefined intrinsic connectivity networks (ICNs) from a large, out of sample independent component analysis and then used them to initialize a spatiotemporal dual regression to estimate participant level connectivity within these ICNs. Specifically, we evaluated connectivity within the speech and language, face and hand sensorimotor, left working memory, salience, superior parietal, supramarginal, insular and deep gray ICNs in a multivariate manner. The spatial maps for each ICN were then compared between PPAOS and control participants. We used clinical measures of apraxia of speech severity to assess for clinical-connectivity correlations for regions found to differ between PPAOS and control participants. Compared to controls, PPAOS participants had reduced connectivity of the right supplementary motor area and left posterior temporal gyrus to the rest of the speech and language ICN. The connectivity of the right supplementary motor area correlated negatively with an articulatory error score. PPAOS participants also had reduced connectivity of the left supplementary motor area to the face sensorimotor ICN, between the left lateral prefrontal cortex and the salience ICN and between the left temporal-occipital junction and the left working memory ICN. The latter connectivity correlated with the apraxia of speech severity rating scale, although the finding did not survive correction for multiple comparisons. Increased connectivity was noted in PPAOS participants between the dorsal posterior cingulate and the left working memory ICN. Our results support the importance of the supplementary motor area in the pathophysiology of PPAOS, which appears to be disconnected from speech and language regions. Supplementary motor area connectivity may serve as a biomarker of degenerative apraxia of speech severity. Keyword: Regular Article URL: https://doi.org/10.1016/j.nicl.2018.02.036 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964833/ http://www.ncbi.nlm.nih.gov/pubmed/29845010 BASE Hide details 18 Tau-PET imaging with [18F]AV-1451 in Primary Progressive Apraxia of Speech Utianski, Rene L.; Whitwell, Jennifer L.; Schwarz, Christopher G.. - 2018 BASE Show details 19 Prosodic and Phonetic Subtypes of Primary Progressive Apraxia of Speech Utianski, Rene L.; Duffy, Joseph R.; Clark, Heather M.. - 2018 BASE Show details 20 Predicting clinical decline in progressive agrammatic aphasia and apraxia of speech Whitwell, Jennifer L.; Weigand, Stephen D.; Duffy, Joseph R.. - : Lippincott Williams & Wilkins, 2017 BASE Show details Page: 1 2 3

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