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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 7 of 7 1 Domain-general subregions of the medial prefrontal cortex contribute to recovery of language after stroke Geranmayeh, Fatemeh; Chau, Tsz Wing; Wise, Richard J. S.. - : Oxford University Press, 2017 BASE Show details 2 Cognitive control and its impact on recovery from aphasic stroke Brownsett, Sonia L.E.; Warren, Jane E.; Geranmayeh, Fatemeh; Woodhead, Zoe; Leech, Robert; Wise, Richard J. S.. - : Oxford University Press, 2014 Abstract: Aphasic deficits are usually only interpreted in terms of domain-specific language processes. However, effective human communication and tests that probe this complex cognitive skill are also dependent on domain-general processes. In the clinical context, it is a pragmatic observation that impaired attention and executive functions interfere with the rehabilitation of aphasia. One system that is important in cognitive control is the salience network, which includes dorsal anterior cingulate cortex and adjacent cortex in the superior frontal gyrus (midline frontal cortex). This functional imaging study assessed domain-general activity in the midline frontal cortex, which was remote from the infarct, in relation to performance on a standard test of spoken language in 16 chronic aphasic patients both before and after a rehabilitation programme. During scanning, participants heard simple sentences, with each listening trial followed immediately by a trial in which they repeated back the previous sentence. Listening to sentences in the context of a listen–repeat task was expected to activate regions involved in both language-specific processes (speech perception and comprehension, verbal working memory and pre-articulatory rehearsal) and a number of task-specific processes (including attention to utterances and attempts to overcome pre-response conflict and decision uncertainty during impaired speech perception). To visualize the same system in healthy participants, sentences were presented to them as three-channel noise-vocoded speech, thereby impairing speech perception and assessing whether this evokes domain general cognitive systems. As expected, contrasting the more difficult task of perceiving and preparing to repeat noise-vocoded speech with the same task on clear speech demonstrated increased activity in the midline frontal cortex in the healthy participants. The same region was activated in the aphasic patients as they listened to standard (undistorted) sentences. Using a region of interest defined from the data on the healthy participants, data from the midline frontal cortex was obtained from the patients. Across the group and across different scanning sessions, activity correlated significantly with the patients’ communicative abilities. This correlation was not influenced by the sizes of the lesion or the patients’ chronological ages. This is the first study that has directly correlated activity in a domain general system, specifically the salience network, with residual language performance in post-stroke aphasia. It provides direct evidence in support of the clinical intuition that domain-general cognitive control is an essential factor contributing to the potential for recovery from aphasic stroke. Keyword: Original Articles URL: https://doi.org/10.1093/brain/awt289 http://www.ncbi.nlm.nih.gov/pubmed/24163248 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891442 BASE Hide details 3 Cognitive control and its impact on recovery from aphasic stroke Brownsett, Sonia L. E.; Warren, Jane E.; Geranmayeh, Fatemeh. - : Oxford University Press, 2014 BASE Show details 4 The contribution of the inferior parietal cortex to spoken language production Geranmayeh, Fatemeh; Brownsett, Sonia L.E.; Leech, Robert. - : Academic Press, 2012 BASE Show details 5 An Investigation of Twenty/20 Vision in Reading Hellyer, Peter J.; Woodhead, Zoé V. J.; Leech, Robert. - : Society for Neuroscience, 2011 BASE Show details 6 A comparison of sensory-motor activity during speech in first and second languages Simmonds, Anna J.; Wise, Richard J. S.; Dhanjal, Novraj S.. - : American Physiological Society, 2011 BASE Show details 7 Two Tongues, One Brain: Imaging Bilingual Speech Production Simmonds, Anna J.; Wise, Richard J. S.; Leech, Robert. - : Frontiers Research Foundation, 2011 BASE Show details

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