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1
Validation of Articulatory Rate and Imprecision Judgments in Speech of Individuals With Amyotrophic Lateral Sclerosis
In: Am J Speech Lang Pathol (2021)
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2
Two Distinct Clinical Phenotypes of Bulbar Motor Impairment in Amyotrophic Lateral Sclerosis
In: Front Neurol (2021)
Abstract: Objective: Understanding clinical variants of motor neuron diseases such as amyotrophic lateral sclerosis (ALS) is critical for discovering disease mechanisms and across-patient differences in therapeutic response. The current work describes two clinical subgroups of patients with ALS that, despite similar levels of bulbar motor involvement, have disparate clinical and functional speech presentations. Methods: Participants included 47 healthy control speakers and 126 speakers with ALS. Participants with ALS were stratified into three clinical subgroups (i.e., bulbar asymptomatic, bulbar symptomatic high speech function, and bulbar symptomatic low speech function) based on clinical metrics of bulbar motor impairment. Acoustic and lip kinematic analytics were derived from each participant's recordings of reading samples and a rapid syllable repetition task. Group differences were reported on clinical scales of ALS and bulbar motor severity and on multiple speech measures. Results: The high and low speech-function subgroups were found to be similar on many of the dependent measures explored. However, these two groups were differentiated on the basis of an acoustic measure used as a proxy for tongue movement. Conclusion: This study supports the hypothesis that high and low speech-function subgroups do not differ solely in overall severity, but rather, constitute two distinct bulbar motor phenotypes. The findings suggest that the low speech-function group exhibited more global involvement of the bulbar muscles than the high speech-function group that had relatively intact lingual function. This work has implications for clinical measures used to grade bulbar motor involvement, suggesting that a single bulbar measure is inadequate for capturing differences among phenotypes.
Keyword: Neurology
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244731/
https://doi.org/10.3389/fneur.2021.664713
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3
Assessing Oromotor Capacity in ALS: The Effect of a Fixed-Target Task on Lip Biomechanics
Eshghi, Marziye; Stipancic, Kaila L.; Mefferd, Antje. - : Frontiers Media, 2020
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4
A speech measure for early stratification of fast and slow progressors of bulbar amyotrophic lateral sclerosis: lip movement jitter ...
Panying Rong; Yunusova, Yana; Marziye Eshghi. - : Taylor & Francis, 2019
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5
A speech measure for early stratification of fast and slow progressors of bulbar amyotrophic lateral sclerosis: lip movement jitter ...
Panying Rong; Yunusova, Yana; Marziye Eshghi. - : Taylor & Francis, 2019
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6
A speech measure for early stratification of fast and slow progressors of bulbar amyotrophic lateral sclerosis: Lip movement jitter
In: Amyotroph Lateral Scler Frontotemporal Degener (2019)
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7
Shorter Sentence Length Maximizes Intelligibility and Speech Motor Performance in Persons With Dysarthria Due to Amyotrophic Lateral Sclerosis
Allison, Kristen M.; Yunusova, Yana; Green, Jordan R.. - : American Speech-Language-Hearing Association, 2019
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8
Automatic extraction of abnormal lip movement features from the alternating motion rate (AMR) task in ALS
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9
Automatic Prediction of Intelligible Speaking Rate for Individuals with ALS from Speech Acoustic and Articulatory Samples
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10
Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems
Rong, Panying; Yunusova, Yana; Wang, Jun. - : Public Library of Science, 2017
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11
Slowed articulation rate is a sensitive diagnostic marker for identifying non-fluent primary progressive aphasia
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12
Profiling Speech and Pausing in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)
Yunusova, Yana; Graham, Naida L.; Shellikeri, Sanjana. - : Public Library of Science, 2016
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13
Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems
In: Special Education and Communication Disorders Faculty Publications (2016)
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14
Predicting Early Bulbar Decline in Amyotrophic Lateral Sclerosis: A Speech Subsystem Approach
Rong, Panying; Yunusova, Yana; Wang, Jun. - : Hindawi Publishing Corporation, 2015
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15
Predicting Early Bulbar Decline in Amyotrophic Lateral Sclerosis: A Speech Subsystem Approach
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16
Articulatory Distinctiveness of Vowels and Consonants: A Data-Driven Approach
In: CSE Journal Articles (2013)
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17
Bulbar and speech motor assessment in ALS: Challenges and future directions
In: Special Education and Communication Disorders Faculty Publications (2013)
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18
Spatiotemporal Coupling of the Tongue in Amyotrophic Lateral Sclerosis
In: Special Education and Communication Disorders Faculty Publications (2012)
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19
Tongue Movements and Their Acoustic Consequences in Amyotrophic Lateral Sclerosis
In: Special Education and Communication Disorders Faculty Publications (2012)
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20
A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis (ALS)
Yunusova, Yana; Green, Jordan R.; Wang, Jun. - : MyJove Corporation, 2011
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