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Cortical microstructure in primary progressive aphasia: a multicenter study.
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In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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| 2 |
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
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In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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| 3 |
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
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In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease.
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Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.
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| 6 |
Factors that predict diagnostic stability in neurodegenerative dementia.
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In: Journal of neurology, vol 266, iss 8 (2019)
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Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.
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| 8 |
Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia.
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In: Brain communications, vol 1, iss 1 (2019)
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| 9 |
Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease.
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Ranasinghe, Kamalini G; Kothare, Hardik; Kort, Naomi; Hinkley, Leighton B; Beagle, Alexander J; Mizuiri, Danielle; Honma, Susanne M; Lee, Richard; Miller, Bruce L; Gorno-Tempini, Maria Luisa; Vossel, Keith A; Houde, John F; Nagarajan, Srikantan S
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In: Scientific reports, vol 9, iss 1 (2019)
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Abstract:
Accurate integration of sensory inputs and motor commands is essential to achieve successful behavioral goals. A robust model of sensorimotor integration is the pitch perturbation response, in which speakers respond rapidly to shifts of the pitch in their auditory feedback. In a previous study, we demonstrated abnormal sensorimotor integration in patients with Alzheimer's disease (AD) with an abnormally enhanced behavioral response topitch perturbation. Here we examine the neural correlates of the abnormal pitch perturbation response in AD patients, using magnetoencephalographic imaging. The participants phonated the vowel /α/ while a real-time signal processor briefly perturbed the pitch(100 cents, 400 ms) of their auditory feedback. We examined the high-gamma band (65-150 Hz) responses during this task. AD patients showed significantly reduced left prefrontal activity during the early phase of perturbation and increased right middle temporal activity during the later phase of perturbation, compared to controls. Activity in these brain regions significantly correlated with the behavioral response. These results demonstrate that impaired prefrontal modulation of speech-motor-control network and additional recruitment of right temporal regions are significant mediators of aberrant sensorimotor integration in patients with AD. The abnormal neural integration mechanisms signify the contribution of cortical network dysfunction to cognitive and behavioral deficits in AD.
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Keyword:
2.1 Biological and endogenous factors; Acoustic Stimulation; Acquired Cognitive Impairment; Aging; Alzheimer Disease; Alzheimer's Disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias; Basic Behavioral and Social Science; Behavioral and Social Science; Biochemistry and Cell Biology; Brain; Brain Disorders; Clinical Research; Dementia; Feedback; Female; Humans; Male; Middle Aged; Neurodegenerative; Neurological; Neurosciences; Other Physical Sciences; Phonation; Pitch Perception; Rehabilitation; Sensory; Speech
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URL: https://escholarship.org/uc/item/3170w5cs
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| 10 |
Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease.
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In: Scientific reports, vol 9, iss 1 (2019)
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| 11 |
Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.
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In: JAMA neurology, vol 75, iss 3 (2018)
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| 12 |
Emotion detection deficits and changes in personality traits linked to loss of white matter integrity in primary progressive aphasia.
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| 13 |
Observing conversational laughter in frontotemporal dementia.
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In: Journal of neurology, neurosurgery, and psychiatry, vol 88, iss 5 (2017)
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| 14 |
Increased prevalence of autoimmune disease within C9 and FTD/MND cohorts: Completing the picture.
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In: Neurology(R) neuroimmunology & neuroinflammation, vol 3, iss 6 (2016)
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| 15 |
Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer's disease.
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In: Human brain mapping, vol 36, iss 11 (2015)
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| 16 |
Sporadic Jakob-Creutzfeldt disease presenting as primary progressive aphasia.
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In: JAMA neurology, vol 70, iss 2 (2013)
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