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Language networks in aphasia and health: A 1000 participant activation likelihood estimation meta-analysis. ...
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Abstract:
Aphasia recovery post-stroke is classically and most commonly hypothesised to rely on regions that were not involved in language premorbidly, through 'neurocomputational invasion' or engagement of 'quiescent homologues'. Contemporary accounts have suggested, instead, that recovery might be supported by under-utilised areas of the premorbid language network, which are downregulated in health to save neural resources ('variable neurodisplacement'). Despite the importance of understanding the neural bases of language recovery clinically and theoretically, there is no consensus as to which specific regions are more likely to be activated in post-stroke aphasia (PSA) than healthy individuals. Accordingly, we performed an Activation Likelihood Estimation (ALE) meta-analysis of language functional neuroimaging studies in PSA. We obtained coordinate-based functional neuroimaging data for 481 individuals with aphasia following left-hemisphere stroke and 530 linked controls from 33 studies that met predefined ...
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Keyword:
Adult; Aged; Aged, 80 and over; Aphasia; Brain; Female; Health Status; Humans; Language; Likelihood Functions; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Net; Stroke
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URL: https://dx.doi.org/10.17863/cam.66662 https://www.repository.cam.ac.uk/handle/1810/319540
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