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Increased connectivity among sensory and motor regions during visual and audiovisual speech perception
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In: Open Access Publications (2022)
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| 2 |
Neural dynamics of semantic categorization in semantic variant of primary progressive aphasia.
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Borghesani, V; Dale, CL; Lukic, S; Hinkley, Lbn; Lauricella, M; Shwe, W; Mizuiri, D; Honma, S; Miller, Z; Miller, B; Houde, JF; Gorno-Tempini, ML; Nagarajan, SS. - : eScholarship, University of California, 2021
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Abstract:
Semantic representations are processed along a posterior-to-anterior gradient reflecting a shift from perceptual (e.g., it has eight legs) to conceptual (e.g., venomous spiders are rare) information. One critical region is the anterior temporal lobe (ATL): patients with semantic variant primary progressive aphasia (svPPA), a clinical syndrome associated with ATL neurodegeneration, manifest a deep loss of semantic knowledge. We test the hypothesis that svPPA patients perform semantic tasks by over-recruiting areas implicated in perceptual processing. We compared MEG recordings of svPPA patients and healthy controls during a categorization task. While behavioral performance did not differ, svPPA patients showed indications of greater activation over bilateral occipital cortices and superior temporal gyrus, and inconsistent engagement of frontal regions. These findings suggest a pervasive reorganization of brain networks in response to ATL neurodegeneration: the loss of this critical hub leads to a dysregulated (semantic) control system, and defective semantic representations are seemingly compensated via enhanced perceptual processing.
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Keyword:
2.1 Biological and endogenous factors; Aged; anterior temporal lobe; Aphasia; Basic Behavioral and Social Science; Behavioral and Social Science; Biochemistry and Cell Biology; Brain Disorders; Clinical Research; Female; human; Humans; magnetoencephalography; Male; Mental Health; Middle Aged; Nerve Degeneration; Neurons; neuroscience; Neurosciences; Primary Progressive; primary progressive aphasia; semantic categorization; semantic dementia; semantic variant ppa; Semantics; Temporal Lobe
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URL: https://escholarship.org/uc/item/6s23q3d9
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| 3 |
A Bayesian optimization approach for rapidly mapping residual network function in stroke. ...
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Age-related differences in the neural bases of phonological and semantic processes in the context of task-irrelevant information.
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| 5 |
Influence of encoding difficulty, word frequency, and phonological regularity on age differences in word naming.
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| 6 |
Age-related differences in the neural bases of phonological and semantic processes.
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| 7 |
Age-related differences in resolving semantic and phonological competition during receptive language tasks.
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Language networks in aphasia and health: A 1000 participant activation likelihood estimation meta-analysis. ...
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| 9 |
A Bayesian optimization approach for rapidly mapping residual network function in stroke.
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| 10 |
Comparing two facets of emotion perception across multiple neurodegenerative diseases.
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In: Social cognitive and affective neuroscience, vol 15, iss 5 (2020)
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| 11 |
Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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| 12 |
Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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| 13 |
Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease.
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| 14 |
Graded, multidimensional intra- and intergroup variations in primary progressive aphasia and post-stroke aphasia.
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In: Brain : a journal of neurology, vol 143, iss 10 (2020)
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| 15 |
Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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| 16 |
Comparing two facets of emotion perception across multiple neurodegenerative diseases.
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In: Social cognitive and affective neuroscience, vol 15, iss 5 (2020)
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| 17 |
Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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| 18 |
More Than Smell-COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis.
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In: Chemical senses, vol 45, iss 7 (2020)
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| 19 |
The Use of Technology for Communicating With Clinicians or Seeking Health Information in a Multilingual Urban Cohort: Cross-Sectional Survey.
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In: Journal of medical Internet research, vol 22, iss 4 (2020)
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The Use of Technology for Communicating With Clinicians or Seeking Health Information in a Multilingual Urban Cohort: Cross-Sectional Survey.
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In: Journal of medical Internet research, vol 22, iss 4 (2020)
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