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Cortical microstructure in primary progressive aphasia: a multicenter study.
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In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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| 2 |
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
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In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
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In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease.
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Chapleau, Marianne; Bedetti, Christophe; Devenyi, Gabriel A; Sheldon, Signy; Rosen, Howie J; Miller, Bruce L; Gorno-Tempini, Maria Luisa; Chakravarty, Mallar M; Brambati, Simona M. - : eScholarship, University of California, 2020
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Abstract:
BackgroundIncreasing evidence shows that the semantic variant of primary progressive aphasia (svPPA) is characterized by hippocampal atrophy. However, less is known about disease-related morphological hippocampal changes. The goal of the present study is to conduct a detailed characterization of the impact of svPPA on global hippocampus volume and morphology compared with control subjects and patients with Alzheimer's disease (AD).MethodsWe measured hippocampal volume and deformation-based shape differences in 22 patients with svPPA compared with 99 patients with AD and 92 controls. Multiple Automatically Generated Templates Brain Segmentation Algorithm (MAGeT-Brain) was used on MRI images obtained at the diagnostic visit.ResultsComparable left and right hippocampal atrophy were observed in svPPA and AD. Deformation-based shape analysis showed a common pattern of morphological deformation in svPPA and AD compared with controls. More specifically, both svPPA and AD showed inward deformations in the dorsal surface of the hippocampus, from head to tail on the left side, and more limited to the anterior portion of the body in the right hemisphere. These results also pointed out that both diseases are characterized by a lateral displacement of the central part (body) of the hippocampus.DiscussionOur study provides critical new evidence of hippocampal morphological changes in svPPA, similar to those found in AD. These findings highlight the importance of considering morphological hippocampal changes as part of the anatomical profile of patients with svPPA.
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Keyword:
2.1 Biological and endogenous factors; Acquired Cognitive Impairment; Adult; Aged; Aging; Alzheimer Disease; Alzheimer's disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer’s disease; Aphasia; Atrophy; Automated segmentation; Biomedical Imaging; Brain; Brain Disorders; Clinical Research; Deformation-based shape analysis; Dementia; Female; Hippocampus; Humans; MAGeT brain; Magnetic Resonance Imaging; Male; Middle Aged; Neurodegenerative; Neurological; Neurosciences; Primary Progressive; Semantic variant of primary progressive aphasia; Semantics
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URL: https://escholarship.org/uc/item/9c4370k3
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| 5 |
Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.
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| 6 |
Factors that predict diagnostic stability in neurodegenerative dementia.
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In: Journal of neurology, vol 266, iss 8 (2019)
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Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.
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| 8 |
Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia.
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In: Brain communications, vol 1, iss 1 (2019)
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| 9 |
Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease.
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In: Scientific reports, vol 9, iss 1 (2019)
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Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease.
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In: Scientific reports, vol 9, iss 1 (2019)
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| 11 |
Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.
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In: JAMA neurology, vol 75, iss 3 (2018)
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| 12 |
Emotion detection deficits and changes in personality traits linked to loss of white matter integrity in primary progressive aphasia.
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| 13 |
Observing conversational laughter in frontotemporal dementia.
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In: Journal of neurology, neurosurgery, and psychiatry, vol 88, iss 5 (2017)
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| 14 |
Increased prevalence of autoimmune disease within C9 and FTD/MND cohorts: Completing the picture.
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In: Neurology(R) neuroimmunology & neuroinflammation, vol 3, iss 6 (2016)
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| 15 |
Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer's disease.
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In: Human brain mapping, vol 36, iss 11 (2015)
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| 16 |
Sporadic Jakob-Creutzfeldt disease presenting as primary progressive aphasia.
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In: JAMA neurology, vol 70, iss 2 (2013)
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